MAGIC BULLET NANOMEDICINES: BRIDGING MOLECULAR TARGETTING AND ADVANCED DRUG DELIVERY TECHNOLOGIES
Abstract
Drug Delivery Systems refer to the science of utilization of technologic advancements and biological polymer materials to deliver drug or gene to the body in clinical time and dose. Targeted drug delivery ensures increased concentration of medication in specific receptors in the body inherently being advantageous with respect to reduction in dose and side effects of drug. This paper discusses about the concept of magic bullet proposed by Paul Ehrlich as well as about the challenges of targeted drug delivery.The various nanocarriers being extensively exploited in targeted delivery are discussed in detail including quantum dots, mesoporous silica materials, metallic nanocarriers, and carbon nanotubes.
Keywords:
Magic Mullet, Blood Brain Barrier, Inaccessible Area, Revolutionize Disease, Off-Target Effect, polymers, nanoparticles, carriers, nanosomes, Targeted Drug Delivery, Nanomedicine
References
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12. Jain KK. Nanotechnology in clinical laboratory diagnostics. Clin Chim Acta. 2005;358(1-2):37-54. doi:10.1016/j.cccn.2005.03.014.
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14. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent. Int J Res Pharm Chem. 2012;2(2):636-649.
15. Sreekanth N, Awen BZ, Rao CB. Development and validation of new analytical methods for the estimation of capecitabine in pharmaceutical dosage form. Res J Pharm Biol Chem Sci. 2012;1(2):39-46.
16. Rani CHU, Sumalatha G, Rao CHB, Varalakshmi TN. Alzheimer’s disease-pharmacotherapeutic interventions. Int J Pharm Chem Sci. 2013;2(2).
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18. Hwisa NT, Katakam P, Chandu BR, Adiki SK. Solvent evaporation techniques as promising advancement in microencapsulation. Vedic Res Int Biol Med Chem. 2013;1(1):8-22.
2. Prabahar K, Alanazi Z, Qushawy M. Targeted drug delivery system: advantages, carriers and strategies. Indian J Pharm Educ Res. 2021;55(2):346-353.
3. Prabahar K, Alanazi Z, Qushawy M. Targeted drug delivery system: advantages, carriers and strategies. Indian J Pharm Educ Res. 2021;55(2):346-353.
4. Ma X, Sánchez S. Self-propelling micro-nanorobots: challenges and future perspectives in nanomedicine. Nanomedicine (Lond). 2017;12(12):1363-1367. doi:10.2217/nnm-2017-0104.
5. Rodrigues RO, Sousa PC, Gaspar J, Bañobre-López M, Lima R, Minas G. Organ-on-a-chip: a preclinical microfluidic platform for the progress of nanomedicine. Small. 2020;16(51):2003517. doi:10.1002/smll.202003517.
6. Mody VV, Siwale R, Singh A, Mody HR. Introduction to metallic nanoparticles. J Pharm Bioallied Sci. 2010;2(4):282-289. doi:10.4103/0975-7406.72127.
7. Paliwal R, Babu RJ, Palakurthi S. Nanomedicine scale-up technologies: feasibilities and challenges. AAPS PharmSciTech. 2014;15(6):1527-1534. doi:10.1208/s12249-014-0177-9.
8. GowriSankar P, Lakshmi Harika V, BhanuVaisalini N, Brahmaiah B, Nama S, Chandu Babu Rao C. Proniosome: a novel approach to vesicular drug delivery system. Pharma Innov J. 2013;2(3):166-173.
9. Demming A. Nanotechnological selection. Nanotechnology. 2013;24(2):020201. doi:10.1088/0957-4484/24/2/020201.
10. Egorov E, Pieters C, Korach-Rechtman H, Shklover J, Schroeder A. Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems. Drug Deliv Transl Res. 2021;11(2):345-352. doi:10.1007/s13346-021-00929-2.
11. Hajialyani M, Tewari D, Sobarzo-Sánchez E, Nabavi SM, Farzaei MH, Abdollahi M. Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems. Int J Nanomedicine. 2018;13:5023-5043. doi:10.2147/IJN.S174072.
12. Jain KK. Nanotechnology in clinical laboratory diagnostics. Clin Chim Acta. 2005;358(1-2):37-54. doi:10.1016/j.cccn.2005.03.014.
13. Gao D, Guo X, Zhang X, Chen S, Wang Y, Chen T, et al. Multifunctional phototheranostic nanomedicine for cancer imaging and treatment. Mater Today Bio. 2020;5:100035. doi:10.1016/j.mtbio.2019.100035.
14. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent. Int J Res Pharm Chem. 2012;2(2):636-649.
15. Sreekanth N, Awen BZ, Rao CB. Development and validation of new analytical methods for the estimation of capecitabine in pharmaceutical dosage form. Res J Pharm Biol Chem Sci. 2012;1(2):39-46.
16. Rani CHU, Sumalatha G, Rao CHB, Varalakshmi TN. Alzheimer’s disease-pharmacotherapeutic interventions. Int J Pharm Chem Sci. 2013;2(2).
17. Kumar AR, Ashok K, Brahmaiah B, Nama S, Baburao C. The cyclodextrins: a review. Int J Pharm Res Bio-Sci. 2013;2(2):291-304.
18. Hwisa NT, Katakam P, Chandu BR, Adiki SK. Solvent evaporation techniques as promising advancement in microencapsulation. Vedic Res Int Biol Med Chem. 2013;1(1):8-22.
Published
20/06/2026
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Yathati, K. (2026). MAGIC BULLET NANOMEDICINES: BRIDGING MOLECULAR TARGETTING AND ADVANCED DRUG DELIVERY TECHNOLOGIES. The Journal of Multidisciplinary Research, 6(2), 6-9. Retrieved from https://www.saapjournals.org/index.php/tjmdr/article/view/909
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