The Journal of Multidisciplinary Research

FORMULATION AND DEVELOPMENT OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR IMPROVED THERAPEUTIC EFFICACY

Abhi Priyatham Yadla — 2026-06-20

In the contemporary world of pharmaceutical sciences and drug delivery research, there is a swift and notable rise in the regulation as well as organizational governance of medications administered via the oral route. This significant increase occurs primarily due to its numerous well-established benefits, the wide availability of multiple diverse formulations that cater to various therapeutic needs. Within this evolving field, a particularly unique and innovative method known as Gastro Retentive Drug Delivery Systems (GRDDs) has emerged as a comprehensive and highly effective approach. These systems are specifically designed to enhance and prolong the duration that the drug remains present in the stomach environment, thereby facilitating the targeted and controlled release of the medication specifically in the upper section of the gastrointestinal tract (GIT). This targeted release mechanism supports both local actions within the gastric region and systemic therapeutic impacts throughout the body as required.including their detailed classification into different categories, the major benefits they offer, the associated constraints and limitations, the critical elements that influence stomach retention duration, methods of assessment and evaluation, the latest developments and innovations in the field, established guidelines criteria, and the promising future outlook of GRDDs moving forward in pharmaceutical research and application.

MAGIC BULLET NANOMEDICINES: BRIDGING MOLECULAR TARGETTING AND ADVANCED DRUG DELIVERY TECHNOLOGIES

Keerthi Yathati — 2026-06-20

Drug Delivery Systems refer to the science of utilization of technologic advancements and biological polymer materials to deliver drug or gene to the body in clinical time and dose. Targeted drug delivery ensures increased concentration of medication in specific receptors in the body inherently being advantageous with respect to reduction in dose and side effects of drug. This paper discusses about the concept of magic bullet proposed by Paul Ehrlich as well as about the challenges of targeted drug delivery.The various nanocarriers being extensively exploited in targeted delivery are discussed in detail including quantum dots, mesoporous silica materials, metallic nanocarriers, and carbon nanotubes.

AI DRIVEN CLINICAL TRIALS: REDEFINING MEDICAL INNOVATION AND RESEARCH EFFICIENCY

Bharaneswar Thagarakunta — 2026-06-22

Artificial Intelligence (AI) has made a noticeable impact on the pharmaceutical industry, transforming several key areas of its operations. Artificial intelligence (AI) is turning the field of clinical trial design, execution, and analysis around by undertaking long-standing issues of high expenses, extended periods, low success rates, and inefficiencies in patient and data number recruitments. AI has been used in clinical trials in protocol optimization, feasibility, analysis of trial outcomes, intelligent patient identification, real time monitoring of data and improved patient engagement. The recent integration of technology providers with pharmaceutical companies has increased the step of practical application of AI in clinical research. The collaboration of Pfizer with IBM Watson to recruit patients to clinical trials, Roche with Google Cloud to develop a digital biomarker, AstraZeneca with Benevolent AI to develop a drug using AI, and others reflect the increasing role of AI in the clinical trial ecosystems. The future of AI application in clinical trials will have to rely on further technological improvement, regulatory modifications, and interdisciplinary cooperation. Moreover AI Can enhance the trial efficiency and cost effective clinical research.