FORMULATION AND DEVELOPMENT OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR IMPROVED THERAPEUTIC EFFICACY

Abhi Priyatham Yadla

Yadla Abhi Priyatham Priyadarshini Institute of Pharmaceutical Education and Research, 5TH Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

In the contemporary world of pharmaceutical sciences and drug delivery research, there is a swift and notable rise in the regulation as well as organizational governance of medications administered via the oral route. This significant increase occurs primarily due to its numerous well-established benefits, the wide availability of multiple diverse formulations that cater to various therapeutic needs. Within this evolving field, a particularly unique and innovative method known as Gastro Retentive Drug Delivery Systems (GRDDs) has emerged as a comprehensive and highly effective approach. These systems are specifically designed to enhance and prolong the duration that the drug remains present in the stomach environment, thereby facilitating the targeted and controlled release of the medication specifically in the upper section of the gastrointestinal tract (GIT). This targeted release mechanism supports both local actions within the gastric region and systemic therapeutic impacts throughout the body as required.including their detailed classification into different categories, the major benefits they offer, the associated constraints and limitations, the critical elements that influence stomach retention duration, methods of assessment and evaluation, the latest developments and innovations in the field, established guidelines criteria, and the promising future outlook of GRDDs moving forward in pharmaceutical research and application.

Keywords: Uses, Categorization, Assessment, Elements, Prospective outlooks, Approach of preparation, Polymers, Recent developments, Regulatory factors

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