Takotsubo cardiomyopathy (Broken heart syndrome)

Kalepu Manisha; Shruti Bhardwaj; Sri Alekhya S.V; Dhanyaswaroopa P; Rishitha Nallamelli; Randeep Raj V.C

doi:10.37022/tjmdr.v3i3.538

Kalepu Manisha Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram.2Student, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram
Shruti Bhardwaj Interns, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram
S.V. Sri Alekhya Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram
P.Dhanyaswaroopa Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram
Rishitha Nallamelli Student, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram
V.C.Randeep Raj Associate Professor, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

DOI https://doi.org/10.37022/tjmdr.v3i3.538

Abstract

Takotsubo cardiomyopathy or takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of non-ischemic cardiomyopathy in which there is a sudden temporary weakening of the muscular portion of the heart. This condition is sometimes called “Broken Heart Syndrome”.it predominantly affects postmenopausal women, often triggered by acute emotional stressors, physical stressors, or a combination of both. The exact pathophysiological mechanisms remain incompletely elucidated. Diagnosis relies on clinical history, physical examination, ECG and cardiomyopathy from acute coronary syndrome is crucial for management.

Keywords: Takotsubo cardiomyopathy, cardiomyopathy

Author Biographies

Kalepu Manisha, Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram.2Student, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram

Interns, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

Shruti Bhardwaj, Interns, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

Interns, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

S.V. Sri Alekhya, Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram

Interns, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

P.Dhanyaswaroopa, Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram

Interns, Avanthi Institute of Pharmaceutical Sciences ,Vizianagaram

Rishitha Nallamelli, Student, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

Student, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

V.C.Randeep Raj, Associate Professor, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

Associate Professor, Avanthi Institute of Pharmaceutical Sciences, Vizianagaram

References

1) Barmore W, Patel H, Harrell S, Garcia D, Calkins Jr JB. Takotsubo cardiomyopathy: A comprehensive review. World J Cardiol 2022; 14(6): 355-362 [PMID: 35979181 DOI: 10.4330/wjc.v14.i6.355]
2) Frangieh AH, Obeid S, Ghadri JR, Imori Y, D'Ascenzo F, Kovac M, Ruschitzka F, Lüscher TF, Duru F, Templin C; InterTAK Collaborators. ECG Criteria to Differentiate Between Takotsubo (Stress) Cardiomyopathy and Myocardial Infarction. J Am Heart Assoc. 2016;5. [PubMed] [DOI] [Cited in This Article: 1].
3) Bybee KA, Kara T, Prasad A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med 2004; 141:858
4) Nef HM, Möllmann H, Kostin S, et al. Tako-Tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J 2007; 28:2456
5) Albakri A (2018) Takotsubo cardiomyopathy: A review of literature on clinical status and meta-analysis of diagnosis and medical therapy. J IntegrCardiol 4: DOI: 10.15761/JIC.1000248
6) Pelliccia F, Kaski JC, Crea F, Camici PG. Pathophysiology of takotsubo syndrome. Circulation. 2017;135:2426–41.
7) Singh, K.; Carson, K.; Usmani, Z.; Sawhney, G.; Shah, R.; Horowitz, J. Systematic review and meta-analysis of incidence and correlates of recurrence of takotsubo cardiomyopathy. Int. J. Cardiol. 2014, 174, 696–701.
8) Patel, S.M.; Chokka, R.G.; Prasad, K.; Prasad, A. Distinctive Clinical Characteristics According to Age and Gender in Apical Ballooning Syndrome (Takotsubo/Stress Cardiomyopathy): An Analysis Focusing on Men and Young Women. J. Card. Fail. 2013, 19, 306–310.
9) Almendro-Delia M, Núñez-Gil IJ, Lobo M, et al. Short- and long-term prognostic relevance of cardiogenic shock in takotsubo syndrome: results from the RETAKO registry. JACC Heart Fail. 2018;6:928-936.
10) Ghadri J-R, Wittstein IS, Prasad A, et al. International expert consensus document on takotsubo syndrome (part II): diagnostic workup, outcome, and management. Eur Heart J. 2018;39:2047-2062.