Evaluation of Antidiabetic Activity of Aqueous Extract of Dianthus Barbatus Leaves in Alloxan Induced Diabetic Rats

Gowthami Nadiminti; Madhavi Kumari M

doi:10.37022/jiaps.v11i3.978

Nadiminti Gowthami Deportment of Pharmacology, Avanti Institute of Pharmaceutical Sciences, Tgarapuvalasa, Vaizayanagarm, Andhra Pradesh, India.
M.Madhavi Kumari Deportment of Pharmacology, Avanti Institute of Pharmaceutical Sciences, Tgarapuvalasa, Vaizayanagarm, Andhra Pradesh, India.

DOI https://doi.org/10.37022/jiaps.v11i3.978

Abstract

Diabetes mellitus is a rapidly growing public health concern in India, with the prevalence of the disease increasing steadily. Although several conventional antidiabetic drugs are available, their long-term use is often associated with adverse effects. Consequently, there is increasing interest in the use of ethnomedicinal plants as affordable and safer alternatives for diabetes management. Dianthus barbatus, a medicinal plant traditionally used for various therapeutic purposes, has not been extensively investigated for its antidiabetic potential.The present study aimed to evaluate the antidiabetic activity and phytochemical profile of the aqueous extract of Dianthus barbatus in alloxan-induced diabetic rats. Diabetes was induced by intraperitoneal administration of alloxan at a dose of 50 mg/kg body weight. The animals were randomly divided into five groups (n = 6): Group I served as the normal control and received the vehicle; Group II served as the diabetic control; Group III received the standard antidiabetic drug glibenclamide (1 mg/kg body weight, orally); and Groups IV and V received the aqueous extract of Dianthus barbatus at doses of 200 mg/kg and 400 mg/kg body weight, respectively, administered orally for 28 days. At the end of the treatment period, blood samples were collected to determine fasting blood glucose, serum glutamate pyruvate transaminase (SGPT), and serum glutamate oxaloacetate transaminase (SGOT) levels. The aqueous extract of Dianthus barbatus produced a significant reduction in blood glucose, SGPT, and SGOT levels at both dose levels compared with the diabetic control group. In addition, treatment with the extract improved body weight in diabetic animals throughout the study period.The findings of this study demonstrate that the aqueous extract of Dianthus barbatus possesses significant antihyperglycemic activity and may offer hepatoprotective benefits in alloxan-induced diabetic rats. These results support the potential of Dianthus barbatus as a promising natural therapeutic agent for the management of diabetes mellitus, warranting further phytochemical and pharmacological investigations to identify its active constituents and elucidate its mechanism of action.

Keywords: Diabetes mellitus, Herbal medicine, Dianthus barbatus, Alloxan, Antidiabetic activity, Phytochemical screening

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