DESIGN, FORMULATION, AND IN VITRO EVALUATION OF CILNIDIPINE FAST DISSOLVING TABLETS USING INNOVATIVE POLYMERIC CARRIERS

Sai Shreeja Alikette; Madhu Chandaka

Alikette Sai Shreeja Department of Pharmacy, MLR Institute of Pharmacy, Dundigal, Hyderabad.
Chandaka Madhu Professor, Department of Pharmacology, MLR Institute of Pharmacy, Dundigal, Hyderabad.

Abstract

This study focused on the formulation and evaluation of fast dissolving tablets of Cilnidipine using novel polymers. Cilnidipine, a calcium channel blocker used in hypertension management, was formulated into six batches (10 mg each) by direct compression. Hydrophilic polymers such as DIVEMA and HPMA were used along with excipients like MCC, SSG, mannitol, talc, and magnesium stearate. The powder blends and tablets were evaluated through pre- and post-compression studies, including FT-IR, DSC, disintegration, and dissolution tests. Among all formulations, batch F1 showed superior performance with rapid drug release and followed first-order kinetics. Cilnidipine, DIVEMA, HPMA, Microcrystalline Cellulose (MCC), Sodium Starch Glycolate (SSG), Mannitol, Fast Dissving Tablets

Keywords: Cilnidipine, DIVEMA, HPMA, Microcrystalline Cellulose (MCC), Sodium Starch Glycolate (SSG), Mannitol, Fast Dissving Tablets

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