Phytochemical Screening and Psychotropic and Anxiolytic Activity of Methanolic Extract of Amaranthus Spinosus

Madhavi Kumari M; Dharani Kranthi K

doi:10.37022/jiaps.v10i2.697

M. Madhavi Kumari Department of Pharmacology, Avanthi Institute of Pharmaceutical Sciences, Cherukupally, Andhra Pradesh, India.
K. Dharani Kranthi Department of Pharmacology, Avanthi Institute of Pharmaceutical Sciences, Cherukupally, Andhra Pradesh, India.

DOI https://doi.org/10.37022/jiaps.v10i2.697

Abstract

Central nervous system disorders are the psychological or behavioral pattern that occur in an individual and are thought to cause distress or disability that is not expected as part of normal development. The present study was undertaken to carry out likely psychotropic and anxiolytic potential of Amaranthus spinosus, extracts and selected fractions of most potential extract.The leaves of Amaranthus spinosus successively extracted with different solvent to obtain extracts (ASL-PE, ASL- CH, ASL-AC, ASL-ME). Further Amaranthus spinosus methanol extract were exhaustively fractionate with the help of soxhlet apparatus to obtain various fraction (ASL-PEF, ASL-CHF, ASL-ACF, ASL-MEF, and were subjected to chemical identification. Preliminary physical phytochemical tests showed presence of flavonoids, alkaloids, glycosides, tannins, and saponins in most of extracts. Based on the results of the in vitro studies, the effect of extracts and fractions was studied in several behavioral animal models like elevated plus maze and light/dark paradigm for its anxiolytic property, lithium sulphate-induced head twitch for its antipsychotic activity for neuropharmacological properties. The plant Amaranthus spinosus showed a promising neuropharmacological and neuroprotective potential in various experimental models.

Keywords: Amaranthus spinosus, phytochemical, psychotropic, anxiolytic, neuroprotective

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