Emerging Developments in Drug Delivery Systems using Solid Lipid Nanoparticles

Jaswanth Bandaru; Lokesh Ullangula; Subha Geetha T; Gayathri B; Babu Rao Ch

doi:10.37022/jiaps.v10i2.688

Bandaru Jaswanth Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017 Andhra Pradesh, India.
Ullangula Lokesh Priyadarshini Institute of Pharmaceutical Education and Research 5th Mile, Pulladigunta, Guntur-522017 Andhra Pradesh, India.
T. Subha Geetha Priyadarshini Institute of Pharmaceutical Education and Research, 5th mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India
B. Gayathri Priyadarshini Institute of Pharmaceutical Education and Research, 5th mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India
Ch. Babu Rao Priyadarshini Institute of Pharmaceutical Education and Research, 5th mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India

DOI https://doi.org/10.37022/jiaps.v10i2.688

Abstract

Nanomedicine and nano-delivery systems are rapidly growing fields that focus on using small materials for targeted drug delivery and diagnostics, offering significant benefits in treating chronic diseases. These systems enhance treatment effectiveness, reduce costs, and improve patient quality of life. Lipid-based carriers, like solid lipid nanoparticles (SLNs), are becoming popular alternatives to polymeric nanoparticles, especially for delivering lipophilic drugs. SLNs have been successful since the approval of Doxil in 1995 and are showing promise for RNA-based treatments, including mRNA vaccines. They are non-toxic, biodegradable, stable, and designed to improve drug bioavailability while targeting specific tissues. Nanostructured lipid carriers (NLCs) and SLNs are particularly useful for drugs with poor solubility and pharmacokinetic profiles. These carriers can be modified to offer advantages over traditional systems like liposomes. SLNs are versatile, stable, and can incorporate both hydrophilic and lipophilic drugs, with new formulations being developed to address drug resistance. Ongoing research explores their preparation, characterization, and applications in gene therapy, vaccines, and protein delivery. Surface-modified SLNs hold promise for targeted and controlled drug delivery, with future research likely expanding their potential for diagnosing and treating various diseases.

Keywords: Nanoparticles, sold lipid nanoparticle, Liposomes, Colloidal drug carriers, homogenization

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