Polymeric nanoparticles – a review
Abstract
Polymeric nanoparticles have emerged as versatile and promising platforms in the field of nanotechnology, offering unique properties and functionalities for various applications. These nanoparticles, typically ranging from 1 to 1000 nanometers in size, are composed of biocompatible or biodegradable polymers, offering controlled drug delivery, imaging capabilities, and targeted therapy. This abstract provides an overview of the synthesis methods, characterization techniques, and applications of polymeric nanoparticles in drug delivery, gene therapy, diagnostics, and imaging. Various polymeric materials, including synthetic and natural polymers, are explored for their suitability in nanoparticle formulations. The choice of polymers influences crucial properties such as biocompatibility, biodegradability, and controlled drug release kinetics, enhancing the therapeutic efficacy and reducing side effects. The ability to encapsulate a diverse range of payloads, including hydrophobic and hydrophilic compounds, makes polymeric nanoparticles highly adaptable for different applications.
Keywords:
Polymer, nanoparticles, gene therapy, biocompatibility, therapeutic efficacy
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References
1. Machado S, Pacheco JG, Nouws HPA, Albergaria JT, Delerue-Matos C. Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts. Sci Total Environ. 2015; 533:76–81.
2. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release. 2001; 70:1–20. doi: 10.1016/S0168-3659(00)00339-4.
3. Schaffazick S.R., Pohlmann A.R., Dalla-Costa T., Guterres S.l.S. Freeze-drying polymeric colloidal suspensions: Nanocapsules, nanospheres and nanodispersion. A comparative study. Eur. J. Pharm. Biopharm. 2003; 56:501–505. doi: 10.1016/S0939-6411(03)00139-5.
4. Malafaya PB, Silva GA, Reis RL. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev 2007.
5. Kong, M.; Chen, X.; Xing, K.; Park, H.J. Antimicrobial properties of chitosan and mode of action: A state of the art review. Int. J. Food Microbial. 2010, 144, 51–63.
6. Iswanti, F.C.; Nurulita, I.; Djauzi, S.; Sadikin, M.; Witarto, A.B.; Yamazaki, T. Preparation, Characterization, and Evaluation of Chitosan-Based Nanoparticles as CpG ODN Carriers. Biotechnol. Biotechnol. Equip. 2019, 33, 390-396.
7. Riyan A.I.R, Tawfiq A.J, Nafisa N.C. Chitosan and its Broad Applications: A Brief Review. Journal of Clinical and Experimental Investigations,2021; 12; 00779.
8. Srivastava A, Prajapati A. Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications. Asian Biomed. 2020; 14(6):217–242. doi:10.1515/abm-2020-0032
9. Run M, Huimin Z, Ziwei W, Shilei H, Bochu W. Preparation of Drug-Loaded Albumin Nanoparticles and Its Application in Cancer Therapy. Journal of Nanomaterials.2022, 12.
10. Weber C, Coester C, Kreuter J, et al. Desolvation process and surface characterisation of protein nanoparticles. Int J Pharm. 2000;194:91–102. doi: 10.1016/s0378-5173(99)00370-1.
11. Lei Y, Nosoudi N, Vyavahare N. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release. 2014; 196:79–86. doi: 10.1016/j.jconrel.2014.09.029.
12. Cascone MG, Sim B, Sandra D. Blends of synthetic and naturalpolymers as drug delivery systems for growth hormone. Bio-materials 1995.
13. Kumari, A.; Yadav, S.K.; Yadav, S.C. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf. B Biointerfaces 2010, 75, 1–18.
14. H.Y. Xue, H.L Wong M. Narvekar, "A nouvel hybrid delivery system: Polymer-oil nanostructured carrier for controlled delivery of highly lipophilic drug all-trans-retinoic acid (ATRA)," International Journal of Pharmaceutics, vo1. 436, pp. 721-731, 2012.
15. Paszko E et al (201 1) Nanodrug applications in photodynamic therapy. Photo-diagnosis Photodyn Ther 8(1):14-29.
16. Ibraheem D, Elaissari A, Fessi H (2014) Gene therapy and DNA delivery systems. Int J Pharm 459(1-2):70-83.
17. Ferrone, M.L., Raut, C.P. Modern SurgicalTherapy: Limb Salvage and the Role of Amputation for Extremity Soft-Tissue Sarcomas. Surg. Oncol. Clin. N. Am. 2012, 21, 201-213.
18. Arafa, M. G.; Girgis, G. N.; El-Dahan, M. S. Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium. Int. J. Nanomedicine 2020 15, 1335-1347. DOI: 10.2147/IJN.S237314.
19. Shen, X.; Li, T.; Chen, Z.; Geng, Y.; Xie, X.; Li, S. Yang, H.; Wu, C.; Liu, Y. Luminescent/Magnetic PLGA-Based Hybrid Nanocomposites: A Smart Nanocarrier System for Targeted Codelivery and Dual-Modality Imaging in Cancer Theranostics. Int. J. Nanomedicine 2017, 12, 4299-4322. DOI: 10.2147/IJN.S136766.
20. Mei, L. , Zhang, Y. , Zheng, Y. , Tian, G. et al., A novel docetaxel‐loaded poly ( ε‐caprolactone)/pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment. Nanoscale Res. Lett. 2009, 4, 1530–1539.
21. Prieto C, Calvo L. Supercritical fluid extraction of emulsions for the production of vitamin E nanocapsulates. XXI Int Conf Bioencapsul. 2013; 1:14.
22. Merkli A., Tabatabay C., Gurny R., Heller J. Biodegradable polymers for the controlled release of ocular drugs. Prog. Polym. Sci. 1998; 23:563–580.
23. Seyedsalehi, A.; Daneshmandi, L.; Barajaa, M.; Riordan, J.; Laurencin, C.T. Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds. Sci. Rep. 2020, 10, 22210
24. Mondal D, Griffith M, Venkatraman SS (2016) Polycaprolactone-based biomaterials for tissue engineering and drug delivery: current scenario and challenges. Int J Polym Mater Polym Biomater 65:255–265.
25. J. Alben and F. Fiamingo, “Fourier transformed infrared spectroscopy,” in Optical Techniques in Biological Research, D. Rousseau, Ed., pp. 133–178, Bell telephone laboratories Inc., 1984.
26. I. Haq, D. Chowdhry, and T. Jenkins, “Calorimetric techniques in the study of high-order DNA-drug interactions,” Methods in Enzymology, vol. 340, pp. 109–149, 2001.
27. K. E. Sapsford, K. M. Tyner, B. J. Dair, J. R. Deschamps, and I. L. Medintz, “Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques,” Analytical Chemistry, vol. 83, no. 12, pp. 4453–4488, 2011.
28. P. C. Lin, S. Lin, P. C. Wang, and R. Sridhar, “Techniques for physicochemical characterization of nanomaterials,” Biotechnology Advances, vol. 32, no. 4, pp. 711–726, 2014.
29. Guma, T.N.; Madakson, P.B.; Yawas, D.S.; Aku, S.Y. - ray diffraction analysis of the microscopies of same corrosion protective bitumen coating. Int. J. Mod. Eng. Res. 2012, 2, 4387-4395.
30. Pappas, N. Calculating retained austenite in steel post magnetic processing using X-ray diffraction. B. S. Undergr. Maths Exch. 2006, 4, 8-14.
2. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release. 2001; 70:1–20. doi: 10.1016/S0168-3659(00)00339-4.
3. Schaffazick S.R., Pohlmann A.R., Dalla-Costa T., Guterres S.l.S. Freeze-drying polymeric colloidal suspensions: Nanocapsules, nanospheres and nanodispersion. A comparative study. Eur. J. Pharm. Biopharm. 2003; 56:501–505. doi: 10.1016/S0939-6411(03)00139-5.
4. Malafaya PB, Silva GA, Reis RL. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev 2007.
5. Kong, M.; Chen, X.; Xing, K.; Park, H.J. Antimicrobial properties of chitosan and mode of action: A state of the art review. Int. J. Food Microbial. 2010, 144, 51–63.
6. Iswanti, F.C.; Nurulita, I.; Djauzi, S.; Sadikin, M.; Witarto, A.B.; Yamazaki, T. Preparation, Characterization, and Evaluation of Chitosan-Based Nanoparticles as CpG ODN Carriers. Biotechnol. Biotechnol. Equip. 2019, 33, 390-396.
7. Riyan A.I.R, Tawfiq A.J, Nafisa N.C. Chitosan and its Broad Applications: A Brief Review. Journal of Clinical and Experimental Investigations,2021; 12; 00779.
8. Srivastava A, Prajapati A. Albumin and functionalized albumin nanoparticles: production strategies, characterization, and target indications. Asian Biomed. 2020; 14(6):217–242. doi:10.1515/abm-2020-0032
9. Run M, Huimin Z, Ziwei W, Shilei H, Bochu W. Preparation of Drug-Loaded Albumin Nanoparticles and Its Application in Cancer Therapy. Journal of Nanomaterials.2022, 12.
10. Weber C, Coester C, Kreuter J, et al. Desolvation process and surface characterisation of protein nanoparticles. Int J Pharm. 2000;194:91–102. doi: 10.1016/s0378-5173(99)00370-1.
11. Lei Y, Nosoudi N, Vyavahare N. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release. 2014; 196:79–86. doi: 10.1016/j.jconrel.2014.09.029.
12. Cascone MG, Sim B, Sandra D. Blends of synthetic and naturalpolymers as drug delivery systems for growth hormone. Bio-materials 1995.
13. Kumari, A.; Yadav, S.K.; Yadav, S.C. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf. B Biointerfaces 2010, 75, 1–18.
14. H.Y. Xue, H.L Wong M. Narvekar, "A nouvel hybrid delivery system: Polymer-oil nanostructured carrier for controlled delivery of highly lipophilic drug all-trans-retinoic acid (ATRA)," International Journal of Pharmaceutics, vo1. 436, pp. 721-731, 2012.
15. Paszko E et al (201 1) Nanodrug applications in photodynamic therapy. Photo-diagnosis Photodyn Ther 8(1):14-29.
16. Ibraheem D, Elaissari A, Fessi H (2014) Gene therapy and DNA delivery systems. Int J Pharm 459(1-2):70-83.
17. Ferrone, M.L., Raut, C.P. Modern SurgicalTherapy: Limb Salvage and the Role of Amputation for Extremity Soft-Tissue Sarcomas. Surg. Oncol. Clin. N. Am. 2012, 21, 201-213.
18. Arafa, M. G.; Girgis, G. N.; El-Dahan, M. S. Chitosan-Coated PLGA Nanoparticles for Enhanced Ocular Anti-Inflammatory Efficacy of Atorvastatin Calcium. Int. J. Nanomedicine 2020 15, 1335-1347. DOI: 10.2147/IJN.S237314.
19. Shen, X.; Li, T.; Chen, Z.; Geng, Y.; Xie, X.; Li, S. Yang, H.; Wu, C.; Liu, Y. Luminescent/Magnetic PLGA-Based Hybrid Nanocomposites: A Smart Nanocarrier System for Targeted Codelivery and Dual-Modality Imaging in Cancer Theranostics. Int. J. Nanomedicine 2017, 12, 4299-4322. DOI: 10.2147/IJN.S136766.
20. Mei, L. , Zhang, Y. , Zheng, Y. , Tian, G. et al., A novel docetaxel‐loaded poly ( ε‐caprolactone)/pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment. Nanoscale Res. Lett. 2009, 4, 1530–1539.
21. Prieto C, Calvo L. Supercritical fluid extraction of emulsions for the production of vitamin E nanocapsulates. XXI Int Conf Bioencapsul. 2013; 1:14.
22. Merkli A., Tabatabay C., Gurny R., Heller J. Biodegradable polymers for the controlled release of ocular drugs. Prog. Polym. Sci. 1998; 23:563–580.
23. Seyedsalehi, A.; Daneshmandi, L.; Barajaa, M.; Riordan, J.; Laurencin, C.T. Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds. Sci. Rep. 2020, 10, 22210
24. Mondal D, Griffith M, Venkatraman SS (2016) Polycaprolactone-based biomaterials for tissue engineering and drug delivery: current scenario and challenges. Int J Polym Mater Polym Biomater 65:255–265.
25. J. Alben and F. Fiamingo, “Fourier transformed infrared spectroscopy,” in Optical Techniques in Biological Research, D. Rousseau, Ed., pp. 133–178, Bell telephone laboratories Inc., 1984.
26. I. Haq, D. Chowdhry, and T. Jenkins, “Calorimetric techniques in the study of high-order DNA-drug interactions,” Methods in Enzymology, vol. 340, pp. 109–149, 2001.
27. K. E. Sapsford, K. M. Tyner, B. J. Dair, J. R. Deschamps, and I. L. Medintz, “Analyzing nanomaterial bioconjugates: a review of current and emerging purification and characterization techniques,” Analytical Chemistry, vol. 83, no. 12, pp. 4453–4488, 2011.
28. P. C. Lin, S. Lin, P. C. Wang, and R. Sridhar, “Techniques for physicochemical characterization of nanomaterials,” Biotechnology Advances, vol. 32, no. 4, pp. 711–726, 2014.
29. Guma, T.N.; Madakson, P.B.; Yawas, D.S.; Aku, S.Y. - ray diffraction analysis of the microscopies of same corrosion protective bitumen coating. Int. J. Mod. Eng. Res. 2012, 2, 4387-4395.
30. Pappas, N. Calculating retained austenite in steel post magnetic processing using X-ray diffraction. B. S. Undergr. Maths Exch. 2006, 4, 8-14.
Published
12/04/2024
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Gillella, S., M, D., S, R., SK, A., T, U. R., C, G., & CH, A. (2024). Polymeric nanoparticles – a review. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 9(1), 25-31. https://doi.org/10.37022/jiaps.v9i1.575
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