Formulation & evaluation of cyclodextrin complexed tablets by enhancing the dissolution rate

Abstract

Tablets are currently the most widely used dosage form due to their ease of self-administration, compactness, and simple production. In many situations, rapid action is necessary rather than conventional therapy. Immediate release dosage forms have become an alternative to traditional oral dose forms in order to address these shortcomings. Immediately after administration, immediate medication release dose forms dissolve more quickly. Super disintegrants such carboxymethylcellulose (Croscarmellose), sodium starch glycolate (Primogel, Explotab), cross-linked polyvinylpyrrolidone (Polyplasdone), and others are employed as the fundamental method in the manufacture of tablets. After being administered to the stomach, these powerful disintegrants instantly dissolve tablets. In this area, parenteral dosage forms and instant release liquid dosage forms have both been introduced for the treatment of patients. It is possible to administer suspensions in liquid dose form using common dispersion agents as hydroxypropyl methylcellulose, AOT (dioctyl sulfosuccinate), etc. Many medications, including neuroleptics, cardiovascular medications, analgesics, antihistamines, and other medications, can be thought of as candidates for this dose form as a result of the advent of immediate release therapy. Pharmaceutical companies frequently create a certain medication entity in a new and improved dosage form as the drug entity's patent life is about to expire. While providing its patient group with a more practical dosage form or dosing schedule, a new dosage form enables a producer to extend market exclusivity.