Formulation and evaluation of microsphere of glipizide
Abstract
The present study aims to carried out to prepare and evaluate the floating microsphere Glipizide using Eudragit RS 100 in a combination with Polyethylene Oxide in various proportions. The following experimental protocol was therefore designed to allow a systemic approach to the study and we concludes that Drug absorption in the GIT is a highly variable process, prolonging gastric retention of the dosage forms and extends the time of drug absorption. Floating hollow microspheres are prepared with enteric coated polymer (Eudragit RS 100) successfully by the solvent evaporation technique. Upon incorporation of the hydrophilic polymer such as polyethylene oxide in the shell of microballoons, the amount of drug released from microspheres could be enhanced.
Keywords:
Microsphere, Glipizide, Polyethylene Oxide, Eudragit, Drug absorption and GIT
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References
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28. Ali Mehramizi, Behnaz Alijani, Mojgan Pourfarzib, Farid A. Dorkoosh, Morteza Rafiee- Tehrani. Solid Carriers for improved solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System. Drug Development and Industrial Pharmacy33, 812-823,2007.
29. Shahla Jamzad, Reza Fassili. Role of Surfactant and pH on Dissolution Properties of Fenofibrate and Glipizide –A technical Note. AAPS.Pharm.Sci.Tech.2006, 7(2) Article33
30. N. Vishal Gupta, C.S. Satish and H.G. Shivakumar. Preparation and characterization of Gelatin-Poly(methacrylic acid) Interpenetrating. Polymeric Network Hydrogels as a pH-sensitive system for Glipizide.Indian Journal of Pharmaceutical Sciences Jan- Feb2007,69(1),64-68.
31. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
32. K.P.R. Chowdary, N. Koteswara Rao and K.Malathi. Ethyl Cellulose Microspheres of Glipizide: Characterization, In-Vitro and In-Vivo evaluation. Indian J.Pharm.Sci.2004,66(4):412- 416.
33. Radha Yeganarayan, Mahesh Surryavanshi, Manmohan Singh, Supriya Desai. A Comparative study of the Glycemic control of various antidiabetic agents and the role of Homocysteine in the therapy of type 2 diabetes mellitus.Journal of Diabetes and its Complications22(2008)104-111.
34. Rajan K. Verma, Sanjay Garg. Selection of excipients for extended release formulations of Glipizide through Drug-excipient compatibility testing.Journal of pharmaceutical and Biomedical Analysis. 38(2005)633-644.
35. E.M. Ghoneim, M.A.El-Attar, E. Hammane, P.Y. Khashala. Stripping Voltametric quantification of the anti-diabetic drug Glipizide in bulk form and pharmaceutical formulation.Journal of pharmaceutical and Biomedical analysis, 43(2007)1465-1469.
2. Chien, Y.W.; Noval drug delivery system, II Edn., Marcel Dekker, New York, 1997; 50: 161- 163.
3. Vyas, S.P., Khar, R.K.; Controlled drug delivery concepts and Advances, I Edn., Vallabh prakashan, Delhi, 2002: 196-205.
4. Guyton, A.C., Hall, J.E.; Text book of medical physiology, IX Edn., Sqender company, Piladelpcia, 1996: 803-805.
5. Tortora, G.J., Grabowski., S.R.; Principles of Anatomy and Physiology, X Edn, John Willey & Sons, Inc., USA, 2002: 868-870.
6. Uppugalla S, Male U, Srinivasan P. Design and synthesis of heteroatoms doped carbon/polyaniline hybrid material for high performance electrode in supercapacitor application. Electrochimica Acta. 2014 Nov 10;146:242-8.
7. Ojha, G.; Floating microspheres development characterization & application. Review, AAPS Pharm. Sci., 2006, 129-140.
8. Arora S., Ali J., Ahuja A.; floating drug delivery system. Review. AAPS Pharm. Sci.,. 2005,372-39.
9. Yeole P.G.; Floating drug delivery system, need & development. Indian J.Pharm. Sci., 2005; 67(3): 265-272.
10. Garg. S., Sharma. S; Gastro-retentive drug delivery system, Pharma Tech., 2003, 27, 50-68.
11. Sato. Y., Kawashima Y., Takeuchi, N.; Physicochemical Properties to determine the buoyancy of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method, Eur. J. Pharm. & Biopham., 2003; 55: 297-304.
12. Male U, Uppugalla S, Srinivasan P. Effect of reduced graphene oxide–silica composite in polyaniline: electrode material for high-performance supercapacitor. Journal of Solid State Electrochemistry. 2015 Nov;19(11):3381-8.
13. Sato, Y., Kawashima, Y., Takeuchi, H.; Invitro evaluation of floating drug releasing behaviour of hollow microspheres (microballoons) prepared by emulsion solvent diffusion method, Eur. J. of Pharm. & Biopharm, 2004; 57: 235-243.
14. atel V.F., Patel N.M., Yeole P.G.; Studies on formulation & Evaluation of Ranitidine Floating tablet, Indian J. Pharm. Sci., 2004; 5(2),34,1-6.
15. Kale R.D., Tayade, P.; A Multiple unit floating drug delivery system of piroxicam using eudragit polymer, Indian J. Pharm. Sci., 2007; 67 (1): 120-123.
16. Dave B.S., Amin, A. F., Patel, M. M.; Gastro-retentive Drug Delivery System of Ranitidine Hydrochloride: formulation and in vitro evaluation, AAPS Pharm Sci. Tech., 2004; 5(2): 34.
17. Uppugalla S, Srinivasan P. High-performance supercapacitor coin cell: polyaniline and nitrogen, sulfur-doped activated carbon electrodes in aqueous electrolyte. Journal of Solid State Electrochemistry. 2019 Jan;23(1):295-306.
18. Muthusamy, K., Govindatuzan. G.; Preparation & Evaluation of Lansoprazole floating Micropellets, Indian. J.Pharm. Sci., 2005; 67(1): 75-79.
19. Streubel, A., Siepmann, J., Bodmeier, R.T.; Floating matrix tablets bared on low density foam powder effects of formulation, processing on drug release, Eur. J. Pharm. Sci.,2003; 13: 37-45.
20. Sato, Y., Kawashima, Y., Takeuchi, H.; Invitro and in vivo evaluation of riboflavin– Containing microballoons for a floating controlled drug delivery system in healthy humans, Int J Pharmaceutics, 2004; 275: 97-107.
21. Srivastava, A.K., Ridhurkar, D.N.; Wadhwa, S.; Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation, Acta Pharm., 2005; 55: 277– 285.
22. Choi, B.Y., Park, H.J., Hwang, S.J.; Preparation of alginate beads for floating drug delivery system effects of CO2 gas forming agents, Int. J. Pharm., 2002; 239: 81-91.
23. Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.
24. Patel, V.F., Patel, N.M.; Intragastric floating drug delivery system of Cefuroxime Axetil, AAPS. Pharm. Sci., 2006; 7(1): 17.
25. Jain, S.K., Agrawal, G.P., Jain, N.K.; evaluation of Porous carrier – bared floating orlistat Microsphere for gastric delivery, AAPS Pharm. Sci. Tech., 2006; 7(4) : 90.
26. Krogel, I., Bodmeier, R.; Floating or pulsatile drug delivery system based on coated effervescent cores, Int. J. Pharm., 1999; 187: 175-184.
27. K.P.R.Chowdary, Y.Srinivasa Rao. Design and In-Vitro evaluation of Mucoadhesive Microcapsules of Glilpzide for Oral Controlled release: A Technical Note. AAPS.Pharm.Sci.Tech2003; 4(3) Article39
28. Ali Mehramizi, Behnaz Alijani, Mojgan Pourfarzib, Farid A. Dorkoosh, Morteza Rafiee- Tehrani. Solid Carriers for improved solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System. Drug Development and Industrial Pharmacy33, 812-823,2007.
29. Shahla Jamzad, Reza Fassili. Role of Surfactant and pH on Dissolution Properties of Fenofibrate and Glipizide –A technical Note. AAPS.Pharm.Sci.Tech.2006, 7(2) Article33
30. N. Vishal Gupta, C.S. Satish and H.G. Shivakumar. Preparation and characterization of Gelatin-Poly(methacrylic acid) Interpenetrating. Polymeric Network Hydrogels as a pH-sensitive system for Glipizide.Indian Journal of Pharmaceutical Sciences Jan- Feb2007,69(1),64-68.
31. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
32. K.P.R. Chowdary, N. Koteswara Rao and K.Malathi. Ethyl Cellulose Microspheres of Glipizide: Characterization, In-Vitro and In-Vivo evaluation. Indian J.Pharm.Sci.2004,66(4):412- 416.
33. Radha Yeganarayan, Mahesh Surryavanshi, Manmohan Singh, Supriya Desai. A Comparative study of the Glycemic control of various antidiabetic agents and the role of Homocysteine in the therapy of type 2 diabetes mellitus.Journal of Diabetes and its Complications22(2008)104-111.
34. Rajan K. Verma, Sanjay Garg. Selection of excipients for extended release formulations of Glipizide through Drug-excipient compatibility testing.Journal of pharmaceutical and Biomedical Analysis. 38(2005)633-644.
35. E.M. Ghoneim, M.A.El-Attar, E. Hammane, P.Y. Khashala. Stripping Voltametric quantification of the anti-diabetic drug Glipizide in bulk form and pharmaceutical formulation.Journal of pharmaceutical and Biomedical analysis, 43(2007)1465-1469.
Published
29/11/2022
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V, V. N., & M, N. (2022). Formulation and evaluation of microsphere of glipizide. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 7(3), 107-112. https://doi.org/10.37022/jiaps.v7i3.362
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