Targets for the development of new anti-tubercular agents
Abstract
In the developing world it is necessary to develop noval drugs to improve the control of tuberculosis. The global resurgence of tuberculosis and rampant drug resistance has urged the importance for the development of new anti tubercular agents, which address different targets, as those of currently used. This review is on development of new target based anti tubercular agents. In this review we have also attempted to look at the current status of anti tubercular drugs to overcome the persistent drug resistant problem and shortening the TB therapy.
Keywords:
mycobacterium, MDR, targets, anti-tubercular agents
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References
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2. Tuberculosis face sheet N 104 WHO. October 2015. Retrieved 2016, 11 February
3. Erwin Heinz Ackerknecht, A Short History of Medicine. JHU Press. 1982.
4. Alagarsamy. V: Text book of medicinal chemistry, Elsevier publisher 2nd edition, volume II, 365 -374.
5. Edson RS, Terrell CL. The aminoglycosides. Mayo Clinic Proceedings. 1999; 74: 519-528.
6. Skinner RH, Cundliffe E. Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them. Journal Gen Microbiology 1980; 120: 95–104.
7. Da Silva AD, De Almeida MV, De Souza MVN, Couri MRC. Biological activity and synthetic methodologies for the preparation of fluoroquinolones, a class of potent antibacterial agents. Current Medicinal Chemistry 2003; 10: 21-39.
8. Khatri GR, Frieden TR. Controlling tuberculosis in India. New England Journal of Medical 2002; 347: 1420-5
9. http://medical-dictionary.thefreedictionary.com/target
10. Haruaki tomioka. Recent Advances in Antituberculous Drug Development and Novel Drug Targets 2008; 2(4):455-471.
11. Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik and Maddamsetty V. Rao. Efforts towards the Development of New Antitubercular Agents: Potential for Thiolactomycin Based Compounds. Journal pharmaceutical science 2008; 11(2): 56s-80s.
12. Worley MV, Estrada SJ. Bedaquiline: A Novel Antitubercular Agent for the Treatment of Multidrug-Resistant Tuberculosis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 2014; 34 (11): 1187–1197.
13. Manjunatha U, Boshoff IM Helena, Barry CE. The mechanism of action of PA-824. Communicative and Integrative Biology 2009; 3: 215–218.
14. Maria Tarcela Gler, Vija Skripconoka, Epifanio Sanchez-Garavito, Heping Xiao, Jose L. Cabrera-Rivero, Dante E. Vargas-Vasquez, Mengqiu Gao, Mohamed Awad, Seung-Kyu Park, Tae Sun Shim, Gee Young Suh, Manfred Danilovits, Hideo Ogata, Anu Kurve, Joon Chang, Katsuhiro Suzuki, Thelma Tupasi, Won-Jung Koh, Barbara Seaworth, Lawrence J. Geiter, and Charles D. Wells. Delamanid for Multidrug-Resistant Pulmonary Tuberculosis. New England Journal of Medicine 2012; 366(23):2151–2160.
15. Jerry R. Colca, William G. McDonald, Daniel J. Waldon, Lisa M. Thomasco, Robert C. Gadwood, Eric T. Lund, Gregory S. Cavey, W. Rodney Mathews, Lonnie D. Adams, Eric T. Cecil, James D. Pearson, Jeffrey H. Bock, John E. Mott, Dean L. Shinabarger, Liqun Xiong and Alexander S. Mankin Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics . Journal of Biological Chemistry 2003; 278(24): 21972–21979.
Published
31/03/2017
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Habeeb, S., & Shifa, S. H. (2017). Targets for the development of new anti-tubercular agents. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 2(1), 01-06. Retrieved from https://www.saapjournals.org/index.php/jiaps/article/view/184
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