Polymeric micelle as a multifunctional therapeutics

Powar Priyatama V; Sharma Padmini  H

Powar Priyatama V Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth-vadgaon.
Sharma Padmini H Department of Pharmaceutics, Padmashree Dr. D.Y. Patil College of Pharmacy, Akurdi, Pune-411044. India.

Abstract

Polymeric micelles are nano-scopic core/shell structures produced by amphiphilic block copolymers with hydrophobic core and hydrophilic shell. Both the inherent and modifiable properties of polymeric micelles construct them particularly well appropriate for drug delivery purposes. In the last two decades, polymeric micelles have been vigorously studied as an innovative type of drug carrier system, because it possesses high stability both in vitro and in vivo and good biocompatibility, and can solubilize a broad variety of poorly soluble drugs. Polymeric micelles can overcome various limitations of the conventional drug delivery system, acting as carriers able to enhance drug absorption, protection of the loaded drug from the harsh environment of the GI tract, release of the drug in a controlled manner at target sites, prolongation of the residence time in the targeted area, and improve the drug accumulation in effectors area. In this review, polymeric micelle drug carrier systems are discussed with a spotlight on designs, types and classifications of the polymeric micelle system. Advantages and disadvantages are briefly summarized and explained, followed by delivery of different drug category.

Keywords: Polymeric Micelles, Nano-scopic, Drug Targeting, Drug Carrier System

Downloads

Download data is not yet available.

References

1. Gong, J.; Chen, M.; Zheng, Y.; Wang, S.; Wang, Y. Polymeric micelles drug delivery system in oncology. J. Control. Release 2012; 159:312–323.
2. Kazunori Kataoka. Development of Polymer-based Nanodevices for Pinpoint Therapy and Diagnostics. Advanced Polymers for Nanobiotechnology 2009; Vol. 58, No. 1.
3. J. B. Hall, M. A. Dobrovolskaia, A. K. Patri, and S. E. McNeil. Characterization of nanoparticles for therapeutics. Nanomedicine 2007; 2(6):789–803.
4. R. G. Strickley. Solubilizing excipients in oral and injectable formulations. Pharmaceutical research 2004; 21(2):201–230.
5. C. J. H. Porter and w. N. Charman. In vitro assessment of oral lipid based formulations. Advanced drug delivery reviews 2001; 50(1):127–147.
6. M.-C. Jones and J.-C. Leroux. Polymeric micelles—a new generation of colloidal drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 1999; 48(2):101–111.
7. M. Yokoyama, G.S. Kwon, T. Okano, Y. Sakurai, T. Seto, K. Kataoka. Preparation of micelle-forming polymer-drug conjugates. Bioconjugate Chem. 1992; 3:295-301
8. Liu Yang et al. Novel Biodegradable Polylactide /poly(ethylene glycol) Micelles Prepared by Direct Dissolution Method for Controlled Delivery of Anticancer Drugs. Pharmaceutical Research 2009; 26(10): 2332-2342.
9. ZhenJiaoa, Na Liua, Zhiming. Selection suitable solvents to prepare paclitaxel-loaded micelles by solvent evaporation method, loaded micelles by solvent evaporation method. Chen Pharmaceutical Development and Technology 2012; 17(2):164-169.
10. Dae Hwan Kang , Gyung Mo Son , Hyun Yul Kim , Je Ho Ryu, Chong Woo Chu, , Su Bum Park ,Young-IL Jeong , Self-Assembled Polymeric Micelles Based on Hyaluronic Acid-g-Poly(D,L-lactide-co-glycolide) Copolymer for Tumor Targeting, Int. J. Mol. Sci. 2014, 15, 16057-16068
11. Jiraphong Suksiriworapong, Tanaporn Rungvimolsin, Atitaya A-gomol, Varaporn Buraphacheep Junyaprasert, Doungdaw Chantasart , Development and Characterization of Lyophilized Diazepam-Loaded Polymeric Micelles, AAPS Pharm Sci Tech. 2014 Feb; 15(1): 52–64.
12. Kang DY, Kim MJ, Kim ST, Oh KS, Yuk SH, Lee S. Size characterization of drug-loaded polymeric core/ shell nanoparticles using asymmetrical flow field-flow fractionation. Anal Bioanal Chem 2008; 390:2183-88.
13. Ramzi A, Rijcken CJF, Veldhuis T, Schwahn D, Hennink WE, Nostrum CF. Core-shell structure of degradable, thermosensitive polymeric micelles studied by smallangle neutron scattering. J Phys Chem B 2008;112:784-92.
14. Dong PW, Wang XH, Gu YC et al. Self-assembled biodegradable micelles based on star-shaped PCL-b- PEG copolymers for chemotherapeutic drug delivery. Colloids Surf A: Physicochem Eng Aspects 2010;358:128-34.
15. Chi SC, Yeom D, Kim SC, Park ES. A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate. Arch Pharm Res 2003; 26:173- 81.
16. Pragnesh N Dave, Vijender Singh, Poonam Khullar , Navjot Kaur, Micelles, mixed micelles, and applications of polyoxypropylene (PPO)-polyoxyethylene (PEO)-polyoxypropylene (PPO) triblock polymers, . International Journal of Industrial Chemistry 2013, 4:12,1-18
17. Lukyanov AN, Torchilin VP. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273–1289.
18. Guo P, Coban O, Snead NM, Trebley J, Hoeprich S, Guo S, Shu Y. Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev 2010, 62:650–666.
19. Guo M, Mao H, Li Y, Zhu A, He H, Yang H, Wang Y, Tian X, Ge C, Peng Q, et al. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials 2014, 35:4656–4666
20. Maria Rosa Aguilar, J.S. Román, Smart Polymers and their Applications, Woodhead publications, Cambrige Uk, 1st,2014,171.