Escheriosome: A potential antigen carrier
Abstract
Escheriosomes are one kind of liposomes grafted from polar lipids extracted from Escherichia coli. These vesicular form elicit high cytotoxic T lymphocyte (CTL) responses. Escheriosomes have shown to deliver their entrapped molecules right into the cytosol of the APCs (Antigen Presenting Cells) that leads to the processing of entrapped antigen via endocytic pathway leading to the antigen presentation by MHC Class I mode. Expression via MHC class I molecules results in CD8+ T cell activation. Escheriosomes may function as a novel immunoadjuvants and emerge as an effective tool for generating protective immunity. It proves to be attractive niche for the scientist in the delivery of vaccine. This review is grafted to highlight its potential as antigenic carrier along with its characterization.
Keywords:
Escheriosomes, Escherichia coli, immunoadjuvants, fusogenic liposomes
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References
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2. Seder RA, Gurunathan S. DNA vaccines—designer vaccines for the 21st century. N Engl J Med 1999; 341:277–8
3. August JD. Alterations in the phospholipid composition of escherichia coli B during growth at different temperatures. Journal of Bacteriology 1969; 100:1342-9.
4. Ingram LO. Changes in lipid composition of escherichia coli resulting from growth with organic solvents and with food additives. Applied and Environmental Microbiology 1977; 33:1233-6.
5. Cronan JE. Phospholipid alterations during growth of Escherichia coli. Journal of Bacteriology 1968; 95:2054-61.
6. Abbady AQ. Evaluation of the immunogenicity and the protective efficacy in mice of a DNA vaccine encoding SP41 from Brucella melitensis. J Infect Dev Ctries 2013; 7:329-37.
7. Luo D, Ni B, Li P, Shi W, Zhang S, Han Y, et al. Protective immunity elicited by a divalent DNA vaccine encoding both the L7/L12 and Omp16 genes of Brucella abortus in BALB/c mice. Infect Immun 2006; 74:2734-41.
8. Al-Mariri A. Protection of BALB/c mice against Brucella melitensis 16M infection induced by vaccination with live Escherchia coli expression Brucella P39 protein. Vaccine 2010; 28:1766-70.
9. Singha H, Mallick AI, Jana C, Isore DP, Goswami TK, Srivastava SK, et al. Escheriosomes entrapped DNA vaccine co-expressing Cu-Zn superoxide dismutase and IL-18 confers protection against Brucella abortus. Microbes Infect 2008; 10:1089-96.
10. Negi LM, Garg AK, Chauhan M. Ultra deformable vesicles: concept and execution. Pharm Times. 2009; 41:11-4.
11. Agarwal R, Katare OP, Vyas S. Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int J Pharm 2001; 228(1-2):43-52.
12. Chauhan A, Swaleha Z, Ahmad N, Farazuddin M, Vasco A, Abida M, et al. Escheriosome mediated cytosolic delivery of Candida albicans cytosolic proteins induces enhanced cytotoxic T lymphocyte response and protective immunity. Vaccine 2011; 29:5424-33.
13. Syed FM, Khan MA, Nasti TH, Ahmad N, Mohammad O. Antigen entrapped in the escheriosomes leads to the generation of CD4(+) helper and CD8(+) cytotoxic T cell response. Vaccine 2003;21:2383-93.
14. Ahmad N, Masood AK, Owais M. Fusogenic potential of prokaryotic membrane lipids. Eur J Biochem 2001; 268:5667–75.
15. Mallick AI, Singha H, Khan S, Anwar T, Ansari MA, Khalid R, et al. Escheriosome-mediated delivery of recombinant ribosomal L7/L12 protein confers protection against murine brucellosis. Vaccine 2007; 25:7873-84.
16. Singhaa H, Mallickb Al, Janaa C, Isorea DP, Goswamia TK. Evaluation of Brucella Abortus Dna Vaccine by Expression of Cu–Zn Superoxide Dismutase Antigen Fused to Il-2 Microbes and Infection Accesed on 7th july,2013;www.lw20.comwww.lw20.com
17. Ahmad M, Deeba F, Faisal SM, Khan A, Agrewala JN, Dwivedi V, et al. Role of fusogenic non-PC liposomes in elicitation of protective immune response against experimental murine salmonellosis. Biochimie 2006; 88(1): 391-400.
18. Chang YF. Novel Liposomes as Potent Vaccine Adjuvants. Cornell center for technology 2013;CCTEC D-4711:2.
19. Azmat Ali Khan, Mumtaz Jabeen, Aijaz Ahmed Khan, Mohammad Owais. Anticancer efficacy of a novel propofol–linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. Nanomedicine 2013:1-14.
20. Sharma MC. Vision 2030 Indian Veterinary Research Institute June, 2011:1-32.
Published
31/03/2016
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Chavda, V. P. (2016). Escheriosome: A potential antigen carrier. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 1(1), 15-20. Retrieved from https://www.saapjournals.org/index.php/jiaps/article/view/168
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