A Review of Gastro Retentive Drug Delivery System

Manjula Devi Muvva

doi:10.37022/jcscr.v2i3.604

Muvva Manjula Devi Priyadarshini Institute of Pharmaceutical Education and Research, 5th mile, Pulladigunta-522017, Guntur, Andhra Pradesh. India.

DOI https://doi.org/10.37022/jcscr.v2i3.604

Abstract

Currently receiving a lot of interest, Gastro Retentive Drug Delivery Systems (GRDDS) are a unique technique that improve the performance of oral controlled release dosage forms. It is the methods used in the pharmaceutical business to provide improved therapeutic outcomes, like flexible formulations, simple dosage administration, and patient compliance. Its foundations include controlled release drug delivery systems (GRDDS) and oral drug delivery systems, which serve as drug reservoirs and release drugs in a predetermined amount of time under controlled conditions. The present review primarily focuses on the requirements for formulating the GRDDS, various approaches involved in formulation, and factors affecting gastric residence time. Alternative approaches to formulate GRDDS include floating drug delivery systems, non-effervescent drug delivery systems, high density drug delivery systems, bio adhesive systems, magnetic systems, and expandable systems. Enhancing the medicine's bioavailability is the primary goal of the gastro-retentive drug delivery method. Basic Anatomy and Physiology of the Gastrointestinal Track, Requirements for Gastro Retentive Drug, Need for Gastro Retention, Factors Affecting Gastro Retentive Time, Benefits and Drawbacks of GRDDS, and Recent Approaches to Gastro-Retentive Drug Delivery System are all covered in this overview.prescription drugs.

Keywords: Gastroretention, Approaches, Anatomy and physiology, Oral Administration

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