Achyranthes aspera ethanolic extract study on cns depressants and behavioral

Abstract

In present study, CNS depressant activity of EEAA was evaluated by Rota rod test, which has clearlyde monstrated the CNS depressant activity evidenced by decreased fall off time. Another important step in evaluating drug actionon CNS is toob serveits effect on locomotor activity of the animal. The activity is a measure of the level of excitability of the CNS; decreased activity results from depression of the central nervous system.22 The extracts significantly decreased the locomotor activity as observed in the results of the Actophotometer test.The fresh, healthy, mature plants were collected from farm of Dhule away from pollution. The plant materials were identified using the Flora of Dhule and in India and herbariums were also preserved. The leaves, stem and roots were washed and used for the present study. The macroscopic observations of the mature plants, leaves, inflorescences and other parts were noted down.Plants contain many bioactive phytochemical substances that produce definite physiological and biochemical action on the human body. The phytochemical research approach is considered to be effective in discovering bioactive profile of plants for therapeutic importance. The total ash was 9.59% and percentage yield of water-soluble extract was 20.91%.This experiment shows the evaluation of qualitative phytoconstituents of water extract of whole plant excluding root of Achyranthesaspera and Achyranthesaspera. The phytochemical analysis of water extract of whole plant excluding root of Achyranthes aspera and Achyranthes aspera 30 shows that various bioactive phytochemicalssuchascarbohydrate,protein, alkaloid and phenolic compounds are retained even with dilution in Homoeopathic 30 potency of Achyranthesaspera.The foam test of Achyranthes aspera 30 is negative whereas of water extract ispositive.