Sustained release of glipizide monolithic matrix tablets formulation & evaluation

Abstract

Glipizide showed maximum absorbance at 276nm.Glipizide was prepared at different concentrations and absorbance was observed at 276nm.A calibration curve was plotted, and the curve observed is linear. Flow properties of the drugBulk density of all formulations range from 0.505 to 0.515. Tapped density of all formulations range from the 0.591 to0.602.Hausner’s ratio of all formulations range varied from1.16 to 1.18. Compressibility Index of all formulations was found to be 13.84% to 15.81% Angle of repose of all formulations was found to be 26.28 to29.75.Hence by the above values, it is confirmed that all the formulation prepared showed good flow properties. Tablet evaluation studiesThe results of the weight variation tests showed values in the desired range varying from 120mg to 123 mg.The thickness of  tablets  prepared  for  allformulation’srangesbetween 4.1mm to4.9mm.The hardness of the tablets for the prepared formulations varied between 5.1kg/cm2 to 6.0kg/cm2.