Formulating & evaluating oral sustained-release diclofenac sodium tablets by using xanthan and cashew gums

Abstract

Introduction: The term modified – release dosage form is used to describe products that alter the timing and rate of release of drug substance. A modified-release dosage form is defined “as one for which the drug release characteristics of time course and/or location are chosen to accomplish therapeutic or convenience objectives not offered by conventional dosage forms such as solutions, ointments, or promptly dissolving dosages forms.

Materials & Methods: Xanthan gum, a polysaccharide, Crude cashew gum, Diclofenac Sodium powder, Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Talc and Magnesium stearate. Wet granulation, Procedure of Wet Granulation in 6-Step.

Results & Discussion : All the batches of tablets passed the uniformity of weight test and drug content test the batches of tablets but batch 3 passed the crushing strength test.All the batches of tablets but batches 4 and 10 passed the friability test. Tablets containing only xanthan gum as release modifier achieved the highest crushing strength friability ratio (CSFR) with those in batch 10 having the lowest. Tablets in batch 2 had the highest swelling index and those in batch 3 had the lowest swelling index. The study has shown that cashew and xanthan gums used alone cannot efficiently control drugrelease. Batches 7 and 8 containing xanthan gum and HPMC were able to cause sustained drug release comparable to Voltaren Retard.Keywords: Rural school children, Nutriment deficiency diseases, Intervention, Eleven Months, Epidemiology work, Data Collection.