Development of sublingual tablets of losartan potassium with enhanced permeation through mucosa

Raja Sekhar Reddy Poonuru; Ramya Sri  Arepally; Rohini  Cheruku; Pavan  Juluri; Lasya Reddy  Enugurthy; Sasya  Asam; Shruthi Bonagiri Bonagiri

Raja Sekhar Reddy Poonuru Principal and Head, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Ramya Sri Arepally Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Rohini Cheruku Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Pavan Juluri Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Lasya Reddy Enugurthy Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Sasya Asam Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.
Shruthi Bonagiri Students, St.Peter’s Institute of Pharmaceutical Sciences, Hanamkonda, Pin-506001, Telangana, India.

Abstract

Losartan potassium is an orally active non peptide angiotensin II receptor antagonist used in treatment of hypertension. Even though oral route is the most preferable and acceptable means of administration, it has become a drawback for those drugs having poor oral bioavailability. Hence sublingual route is one of the preferable routes to overcome such deviations and also ensures most rapid and complete absorption of the drug due to its high vasculature. The aim of the present work is to develop sublingual tablets of Losartan Potassium with enhanced permeation through mucosa since it is a highly water soluble and weakly basic drug with poor oral bioavailability. Two techniques have been used for the permeation enhancement: Lipid matrix systems and pH_max technique. Lipids like Compritol 888 ATO and Precirol ATO were used in lipid matrix systems and dibasic sodium phosphate was used as buffering agent in pH_max technique. The tablets were evaluated for various evaluation parameters. FTIR studies were also performed for drug excipient compatibility. The results showed both of the techniques were enough sufficient in improving the release of the drug.

Keywords: Sublingual, Losartan Potassium, Lipid Carrier, Buffering Agent, Lipid Matrix Systems

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