Synthesis of biologically active compounds derived from natural products

Sowmya Mudunuru; Chandra Sekhara Rao Gurubilli; V.R.Sharma G; Srinivasa Rao G

doi:10.46796/ijpc.v4i2.444

Sowmya Mudunuru Research Scholar, Department of Chemistry, GITAM Deemed to be University, Visakhapatnam & Assistant Professor, Department of Chemistry, MahaRajah's College (A), Vizianagaram.
Chandra Sekhara Rao Gurubilli Research Scholar, Department of Chemistry, GITAM Deemed to be University & Assistant Professor, Department of Chemistry, MahaRajah's College (A), Vizianagaram.
G.V.R.Sharma Professor, Department of Chemistry, GITAM Deemed to be University, Visakhapatnam.
G.Srinivasa Rao Assistant Professor, Department of Chemistry, GITAM Deemed to be University, Visakhapatnam.

DOI https://doi.org/10.46796/ijpc.v4i2.444

Abstract

Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established.

Keywords: natural products, antibiotics, total synthesis, enantiospecific synthesis, carbohydrates, glycosidase inhibitors

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