COMPREHENSIVE REVIEW ON HYDROGELS FOR CONTROLLED DRUG RELEASE
Abstract
This review provides a comprehensive overview of the use of polymer gel in drug administration mechanism. In 1891, to their modern practices in reparative drug, towel design, and agriculture. It highlights the part of hydrogels in prolixity controlled, swelling-controlled, and chemically controlled medicine delivery systems. It also explores the use of hydrogels in colorful medicine delivery routes, including subcutaneous, oral, rectal, and topical transdermal administration and provides exemplifications of retailed hydrogel products for medicine delivery.
Keywords:
Hydrogels, Controlled release, drug delivery system, oral, injectable, topical, ocular Contact lenses, Tissues
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References
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23. Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today. 2013;16(12):496-504.
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26. Pellá MC, Lima-Tenório MK, Tenório-Neto ET, Guilherme MR, Muniz EC, Rubira AF. Chitosan-based hydrogels: From preparation to biomedical applications. Carbohydr Polym. 2018;196:233-245.
27. Onaciu A, Munteanu RA, Moldovan AI, Moldovan CS, Berindan-Neagoe I. Hydrogels based drug delivery synthesis, characterization and administration. Pharmaceutics. 2019;11(9):432.
28. Adams TS, Crook T, Cadier MA. A late complication following the insertion of hydrogel breast implants. J Plast Reconstr Aesthet Surg. 2007;60(2):210-212.
29. Nandipati MC, Sumalatha G, Baburao C, Babu JR, Sridevi C. Antitumor activity of Mimosa rubicaulis Lam. against Ehrlich ascites carcinoma in Swiss albino mice. Int J Pharm Sci Res. 2014;5(4):1514-1519.
2. Hoare TR, Kohane DS. Hydrogels in drug delivery: Progress and challenges. Polymer. 2008;49(8):1993-2007.
3. Nama S, Awen BZ, Chandu BR, Khagga M. A novel stability indicating liquid chromatographic assay for the estimation of rimonabant hydrochloride in bulk and pharmaceutical dosage forms. Afr J Pharm Sci Pharm. 2011;2(1).
4. Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science. 1980;210(4472):908-910.
5. Chauhan N, Saxena K, Jain U. Hydrogel based materials: A progressive approach towards advancement in biomedical applications. Mater Today Commun. 2022;33:104369.
6. Ahmed EM. Hydrogel: Preparation, characterization, and applications: A review. J Adv Res. 2015;6(2):105-121.
7. Poursamar SA, Lehner AN, Azami M, Ebrahimi-Barough S, Samadikuchaksaraei A, Antunes AP. The effects of crosslinkers on physical, mechanical, and cytotoxic properties of gelatin sponge prepared via in-situ gas foaming method as a tissue engineering scaffold. Mater Sci Eng C. 2016;63:1-9.
8. Sahai MK, Sasi B, Rao CB, Jayakumar T. A study on magnetic Barkhausen emission using Monte Carlo simulation. Insight Non-Destr Test Cond Monit. 2012;54(5):262-266.
9. Prasanthi G, Chandu BR, Pradeep Kumar Y, Swarnalatha D, Gopinath C. Chemical pharmacology of khat leaves. J Glob Trends Pharm Sci. 2014;5(4):2024-2029.
10. Rehman WU, Asim M, Hussain S, Khan SA, Khan SB. Hydrogel: A promising material in pharmaceutics. Curr Pharm Des. 2020;26(45):5892-5908.
11. Denzer BR, Kulchar RJ, Huang RB, Patterson J. Advanced methods for the characterization of supramolecular hydrogels. Gels. 2021;7(4):158.
12. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in bulk and pharmaceutical dosage forms. Trop J Pharm Res. 2011;10(4):489-495.
13. Estroff LA, Leiserowitz L, Addadi L, Weiner S, Hamilton AD. Characterization of an organic hydrogel: A cryo-transmission electron microscopy and X-ray diffraction study. Adv Mater. 2003;15(1):38-42.
14. Wang R, Tian Y, Wang J, Song W, Cong Y, Wei X, Mei Y, Miyatake H, Ito Y, Chen YM. Biomimetic glucose trigger-insulin release system based on hydrogel loading bidentate β-cyclodextrin. Adv Funct Mater. 2021;31(38):2104488.
15. Schuetz YB, Gurny R, Jordan O. A novel thermoresponsive hydrogel based on chitosan. Eur J Pharm Biopharm. 2008;68(1):19-25.
16. Sokker HH, Ghaffar AA, Gad YH, Aly AS. Synthesis and characterization of hydrogels based on grafted chitosan for the controlled drug release. Carbohydr Polym. 2009;75(2):222-229.
17. Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK. Drug delivery systems: An updated review. Int J Pharm Investig. 2012;2(1):2-11.
18. Shih TY, Blacklow SO, Li AW, Freedman BR, Bencherif SA, Koshy ST, Darnell MC, Mooney DJ. Injectable, tough alginate cryogels as cancer vaccines. Adv Healthc Mater. 2018;7(10):1701469.
19. Pugliese R, Gelain F. Cross-linked self-assembling peptides and their post-assembly functionalization via one-pot and in situ gelation system. Int J Mol Sci. 2020;21(12):4261.
20. Hiemstra C, Zhong Z, Van Tomme SR, van Steenbergen MJ, Jacobs JJ, Den Otter W, Hennink WE, Feijen J. In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels. J Control Release. 2007;119(3):320-327.
21. Lin CC, Metters AT. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58(12-13):1379-1408.
22. Ramalingam P, Reddy DR, Rao CB, Babu RH, Vasudev R. In vitro antitubercular, antibacterial and antifungal activities of 4-(3,4-disubstituted) benzylidene-2-phenyloxazolin-5-ones and their phenyl acrylohydrazides. Indian J Heterocycl Chem. 2014;23(3):321-330.
23. Bose S, Vahabzadeh S, Bandyopadhyay A. Bone tissue engineering using 3D printing. Mater Today. 2013;16(12):496-504.
24. Bhalerao SB, Mahajan VR, Maske RR. Hydrogel based drug delivery system: A review. World J Biol Pharm Health Sci. 2022;12:39-53.
25. Xu J, Tam M, Samaei S, Lerouge S, Barralet J, Stevenson MM, Cerruti M. Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis. Acta Biomater. 2017;48:247-257.
26. Pellá MC, Lima-Tenório MK, Tenório-Neto ET, Guilherme MR, Muniz EC, Rubira AF. Chitosan-based hydrogels: From preparation to biomedical applications. Carbohydr Polym. 2018;196:233-245.
27. Onaciu A, Munteanu RA, Moldovan AI, Moldovan CS, Berindan-Neagoe I. Hydrogels based drug delivery synthesis, characterization and administration. Pharmaceutics. 2019;11(9):432.
28. Adams TS, Crook T, Cadier MA. A late complication following the insertion of hydrogel breast implants. J Plast Reconstr Aesthet Surg. 2007;60(2):210-212.
29. Nandipati MC, Sumalatha G, Baburao C, Babu JR, Sridevi C. Antitumor activity of Mimosa rubicaulis Lam. against Ehrlich ascites carcinoma in Swiss albino mice. Int J Pharm Sci Res. 2014;5(4):1514-1519.
Published
20/06/2026
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How to Cite
Subbara, V. “COMPREHENSIVE REVIEW ON HYDROGELS FOR CONTROLLED DRUG RELEASE”. International Journal of Health Care and Biological Sciences, Vol. 7, no. 3, June 2026, pp. 1-5, https://www.saapjournals.org/index.php/ijhcbs/article/view/902.
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Review Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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