DESIGN, DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM
Abstract
An efficient and patient-friendly substitute for traditional oral and parenteral dosing forms is the transdermal drug delivery system (TDDS). Together, the reviewed papers demonstrate the increasing significance of transdermal patches in providing prolonged and regulated medication release via the skin into the bloodstream. Avoiding first-pass metabolism, increasing bioavailability, decreasing the frequency of doses, minimizing variations in plasma levels, and improving patient compliance are only a few benefits of TDDS.
Keywords:
Transdermal Drug Delivery System (TDDS), Transdermal Patches, Controlled Drug Release, Skin Permeation, Drug–Skin Interaction, Backing Membrane
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References
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15. Sahoo SS, Rao C, Mehta A. Formulation development and optimization of nanosuspension of simvastatin for improved solubility by nanomilling. J Pharm SciTech. 2015;5(2):78-86.
16. Mishra N, Jain P. A comprehensive review on transdermal patch of ciprofloxacin hydrochloride. Int J Adv Pharm Med Bioallied Sci. 2022;10(2):82-87. doi:10.5281/zenodo.7047439.
17. Kumar KR, Rao CH, Rao CB, Chandra KB. RP-HPLC method development and validation for estimation of capecitabine in capsules. Int J Chem Tech Res. 2010;2:307-311.
18. Wong WF, Ang KP, Sethi G, Looi CY. Recent advancement of medical patch for transdermal drug delivery. Medicina (Kaunas). 2023;59(4):778. doi:10.3390/medicina59040778.
19. Sreekanth N, Awen BZ, Rao CB. A new colorimetric determination and validation of sparfloxacin based on ferric nitrate chromogen. Res J Pharm Biol Chem Sci. 2010;1:9-13.
20. Reddy G, Durga G, Srilekha Y, Ratnakumari P. Review on transdermal drug delivery system. Int J Pharm Drug Anal. 2021;9(4):236-240.
2. Roberts MS. Targeted drug delivery to the skin and deeper tissues: role of physiology, solute structure and disease. Clin Exp Pharmacol Physiol. 1997;24(11):874-879. doi:10.1111/j.1440-1681.1997.tb02708.x.
3. Sarvani V, Elisha RP, Nama S, Pola LM, Rao CB. Process validation: an essential process in pharmaceutical industry. Int J Med Chem Anal. 2013;3(2):49-52.
4. Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Buhse LF. Transdermal drug delivery system (TDDS) adhesion as a critical safety, efficacy and quality attribute. Eur J Pharm Biopharm. 2006;64(1):1-8. doi:10.1016/j.ejpb.2006.03.009.
5. Buchiraju R, Nama S, Sakala B, Chandu BR, Kommu A, Chebrolu JK, et al. Res J Pharm Biol Chem Sci.
6. Bariya SH, Gohel MC, Mehta TA, Sharma OP. Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol. 2012;64(1):11-29. doi:10.1111/j.2042-7158.2011.01369.x.
7. Hwisa NT, Katakam P, Chandu BR, Adiki SK. Solvent evaporation techniques as promising advancement in microencapsulation. Vedic Res Int Biol Med Chem. 2013;1:8-22.
8. Purushotham K, Vijetha KA. A review on transdermal drug delivery system. GSC Biol Pharm Sci. 2023;22(2):245-255. doi:10.30574/gscbps.2023.22.2.0053.
9. Avinash M, Suryaprabha M, Sreekanth N, Dineshreddy B, Baburao CH. Advanced and recent emerging trends in insulin drug delivery systems. Int J Bio-Pharma Res. 2012;1.
10. Ramteke KH, Dhole SN, Patil SV. Transdermal drug delivery system: a review. J Adv Sci Res. 2012;3(1):22-35.
11. Victor A, Khader A, Rao C, Mehta A. Build an IEEE 802.15.4 wireless sensor network for emergency response notification for indoor situations. Int J Electron. 2012.
12. Williams AC, Barry BW. Penetration enhancers. Adv Drug Deliv Rev. 2012;64(Suppl):128-137. doi:10.1016/j.addr.2012.09.032.
13. Dasari VA, Chandu BR, Khagga MU, Gindi SU. New simple UV spectrophotometric method for the estimation of valganciclovir in bulk and its formulation. Int J Adv Pharm Sci. 2010;1:282-292.
14. Jadhav NR, Bhangale CD, Chaudhari MA, Deshmukh TA. Physical approach to transdermal drug delivery: a review. J Drug Deliv Ther. 2017;7(3):28-35. doi:10.22270/jddt.v7i3.1435.
15. Sahoo SS, Rao C, Mehta A. Formulation development and optimization of nanosuspension of simvastatin for improved solubility by nanomilling. J Pharm SciTech. 2015;5(2):78-86.
16. Mishra N, Jain P. A comprehensive review on transdermal patch of ciprofloxacin hydrochloride. Int J Adv Pharm Med Bioallied Sci. 2022;10(2):82-87. doi:10.5281/zenodo.7047439.
17. Kumar KR, Rao CH, Rao CB, Chandra KB. RP-HPLC method development and validation for estimation of capecitabine in capsules. Int J Chem Tech Res. 2010;2:307-311.
18. Wong WF, Ang KP, Sethi G, Looi CY. Recent advancement of medical patch for transdermal drug delivery. Medicina (Kaunas). 2023;59(4):778. doi:10.3390/medicina59040778.
19. Sreekanth N, Awen BZ, Rao CB. A new colorimetric determination and validation of sparfloxacin based on ferric nitrate chromogen. Res J Pharm Biol Chem Sci. 2010;1:9-13.
20. Reddy G, Durga G, Srilekha Y, Ratnakumari P. Review on transdermal drug delivery system. Int J Pharm Drug Anal. 2021;9(4):236-240.
Published
02/06/2026
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[1]
V. Rayapati, “DESIGN, DEVELOPMENT AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM”, Int J Indig Herb Drug, vol. 11, no. 2, pp. 5-8, Jun. 2026.
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Review Articles
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