Formulation development and evaluation of bilayer tablets of sucralfate and amoxycillin for the effective treatment of ulcer

Abstract

Objective: The present research was carried out with the aim of developing bilayer tablets of sucralfate and amoxycillin for the effective treatment of ulcer.

Methods: Development of bilayer tablet of sucralfate and amoxycillin was carried out by the direct compression method. Finally it was optimized according to several evaluation parameters.

Results: Based on the cumulative dissolution studies of sucralfate and amoxcillin similarity factor and other physical evaluation studies, the IF8 and F8 formulation were present exhibited good properties of bilayer tablet formulation in terms of excipient proportion. Formulate instant release layer and control release layer individually passed the pre-compression tests that are angle of repose, bulk density, tapped bulk density, compressibility index, and hausner’s ratio. The instant release layer of released approx 99.89 percent of drug within 15 min and control release layer released approx 99.89 percent of drug up to 12 hrs.

Conclusion: Experiment concluded that bi-layer tablet is suitable for delivering same drugs with different release pattern like one layer of drug as immediate release to get quick relief from pain and second drug as sustained release of drug which gives effect of drug for sufficient long time and reduce frequency of dose.