Formulation and evaluation of transdermal patch of vildagliptin

Renuka Namdeo Renuka Namdeo; Mukesh Kumar Patel Mukesh Kumar Patel; Ashish Manigauha Ashish Manigauha; Arun Pandey Arun Pandey

Renuka Namdeo Mittal Institute of Pharmacy, Bhopal-462038, MP (India)
Mukesh Kumar Patel Mittal Institute of Pharmacy, Bhopal-462038, MP (India)
Ashish Manigauha Mittal Institute of Pharmacy, Bhopal-462038, MP (India)
Arun Pandey Mittal Group of Institutions, Bhopal-462038, MP (India)

Abstract

Objective: In the present research, the transdermal patch of vildagliptin was fabricated by using sustained release hydrophilic and lipophilic polymers containing permeation enhancer and thoroughly evaluated.

Methods: The transdermal patches of vildagliptin were prepared using the combination of polymers in different concentration with permeation enhancer and plasticizer was used for the formulating transdermal drug delivery system. The thickness, folding endurance, tensile strength, percentage of moisture content, percentage of moisture uptake, drug content analysis, scanning electron morphology (SEM) was evaluated.

Results: All the formulation was studied and all data fitted on zero order and first order, to explain the diffusion mechanism and pattern. The % cumulative drug release was calculated over the study time range in 0-10 h. Data analysis for order of release kinetics the formulation followed zero order release kinetics. From the in-vitro permeation study it was confirmed that the release of formulation F3 was to be found higher as compared to other formulation.

Conclusion: The preparation of matrix type transdermal patch appears to be a most effective approach from the process development and scale-up point of view.

Keywords: Transdermal patch, Vildagliptin, Polymers, Permeation enhancer, Plasticizer, Transdermal drug delivery system

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