Contemporary Approaches to Cervical Cancer Management
Abstract
Cervical cancer represents a widespread global health concern, responsible for considerable morbidity and mortality among women around the world. The illness is mainly triggered by long-lasting infection with high-risk human papillomavirus (HPV) types. Although effective preventive measures such as HPV vaccination and screening are available, cervical cancer persists as a primary cause of cancer-related fatalities among women in low- and middleincome nations. Recent progress in understanding the biology of cervical cancer has prompted the creation of new therapeutic methods, encompassing targeted therapies and immunotherapies. These cutting-edge treatments have displayed encouraging outcomes in enhancing patient results, especially in advanced-stage and recurrent cases. This review intends to deliver a thorough summary of the existing knowledge regarding cervical cancer, encompassing its epidemiology, prevention methods, diagnostic techniques, and treatment possibilities. We also examine recent advancements in cervical cancer research and their potential effects on patient care.
Keywords:
cervical cancer, HPV, immuno therapy, screening, chemotherapy
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References
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https://doi.org/10.1016/j.jnma.2020.03.002
2 Cohen PA, Jhingran A, Oaknin A, Denny L. Cervical cancer. The Lancet. 2019 Jan 12;393(10167):169-82.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)30003-0/fulltext
3. Chrysostomou AC, Stylianou DC, Constantinidou A, Kostrikis LG. Cervical cancer screening programs in Europe: the transition towards HPV vaccination and population-based HPV testing. Viruses. 2018 Dec 19;10(12):729.
.https://doi.org/10.3390/v10120729
4. Pal A, Kundu R. Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy. Frontiers in microbiology. 2020 Jan 21;10:3116.
.https://doi.org/10.3389/fmicb.2019.03116
5. Buskwofie A, David-West G, Clare CA. A review of cervical cancer: incidence and disparities. Journal of the National Medical Association. 2020 Apr 1;112(2):229-32.
https://doi.org/10.1016/j.jnma.2020.03.002
6. Chrysostomou AC, Stylianou DC, Constantinidou A, Kostrikis LG. Cervical cancer screening programs in Europe: the transition towards HPV vaccination and population-based HPV testing. Viruses. 2018 Dec 19;10(12):729.
https://doi.org/10.3390/v10120729
7. Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC, Castle PE. Human papillomavirus testing in the prevention of cervical cancer. Journal of the National cancer institute. 2011 Mar 2;103(5):368-83. https://doi.org/10.1093/jnci/djq562
8. Kopp SA, Turk DE. Human Papillomavirus Vaccinations: Provider Education to Enhance Vaccine Uptake. Clinical pediatrics. 2023 Sep;62(8):840-8.
https://doi.org/10.1177/00099228221147850
9. Kopp SA, Turk DE. Human Papillomavirus Vaccinations: Provider Education to Enhance Vaccine Uptake. Clinical pediatrics. 2023 Sep;62(8):840-8.
https://doi.org/10.1177/00099228221147850
10. Patel-Lippmann K, Robbins JB, Barroilhet L, Anderson B, Sadowski EA, Boyum J. MR imaging of cervical cancer. Magnetic Resonance Imaging Clinics. 2017 Aug 1;25(3):635-49. https://doi.org/10.1016/j.mric.2017.03.007
11. Fischerova D, Cibula D, Stenhova H, Vondrichova H, Calda P, Zikan M, Freitag P, Slama J, Dundr P, Belacek J. Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. International Journal of Gynecological Cancer. 2008 Jul 1;18(4):766-772.
https://doi.org/10.1136/ijgc-00009577-200807000-00024
12. Serrano B, Ibáñez R, Robles C, Peremiquel-Trillas P, De Sanjosé S, Bruni L. Worldwide use of HPV self-sampling for cervical cancer screening. Preventive medicine. 2022 Jan 1;154:106900 https://doi.org/10.1016/j.ypmed.2021.106900
13. Serrano B, Ibáñez R, Robles C, Peremiquel-Trillas P, De Sanjosé S, Bruni L. Worldwide use of HPV self-sampling for cervical cancer screening. Preventive medicine. 2022 Jan 1;154:106900 https://doi.org/10.1016/j.ypmed.2021.106900
14. Gizaw M, Teka B, Ruddies F, Abebe T, Kaufmann AM, Worku A, Wienke A, Jemal A, Addissie A, Kantelhardt EJ. Uptake of cervical cancer screening in Ethiopia by self-sampling HPV DNA compared to visual inspection with acetic acid: a cluster randomized trial. Cancer Prevention Research. 2019 Sep 1;12(9):609-16.
https://doi.org/10.1158/1940-6207.CAPR-19-0156
15. Serrano B, Ibáñez R, Robles C, Peremiquel-Trillas P, De Sanjosé S, Bruni L. Worldwide use of HPV self-sampling for cervical cancer screening. Preventive medicine. 2022 Jan 1;154:106900 https://doi.org/10.1016/j.ypmed.2021.106900
16. Wang R, Pan W, Jin L, Huang W, Li Y, Wu D, Gao C, Ma D, Liao S. Human papillomavirus vaccine against cervical cancer: Opportunity and challenge. Cancer letters. 2020 Feb 28;471:88-102. https://doi.org/10.1016/j.canlet.2019.11.039
17. Kopp SA, Turk DE. Human Papillomavirus Vaccinations: Provider Education to Enhance Vaccine Uptake. Clinical pediatrics. 2023 Sep;62(8):840-8.
https://doi.org/10.1177/00099228221147850
18. Perkins RB, Stier EA. Should US women be screened for cervical cancer with pap tests, HPV tests, or both?.
Annals of internal medicine. 2014 Aug 19;161(4):295-7. https://doi.org/10.7326/M14-1043
19. Bosch FX, Broker TR, Forman D, Moscicki AB, Gillison ML, Doorbar J, Stern PL, Stanley M, Arbyn M, Poljak M, Cuzick J. Comprehensive control of human papillomavirus infections and related diseases. Vaccine. 2013 Dec 31;31:H1-31. https://doi.org/10.7326/M14-1043
20. Wang X, Huang X, Zhang Y. Involvement of human papillomaviruses in cervical cancer. Frontiers in microbiology. 2018 Nov 28;9:2896.
https://doi.org/10.3389/fmicb.2018.02896
Published
01/08/2025
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[1]
P. Polu, “Contemporary Approaches to Cervical Cancer Management”, Int J Indig Herb Drug, vol. 10, no. 3, pp. 1-6, Aug. 2025.
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