Preparation and Evaluation of Polyherbal Anti Diabetic Tablets

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder associated with long-term complications and poses a serious global health challenge. It includes two main types: Insulin-Dependent Diabetes Mellitus (IDDM) and Non-Insulin Dependent Diabetes Mellitus (NIDDM). Herbal medicines have gained significant attention in the management of diabetes due to their lower side effects and better patient acceptance. Herbal antidiabetic drugs help manage diabetes by lowering blood glucose levels and enhancing insulin secretion from the pancreas. With the growing global demand for herbal formulations, numerous plants with reported antidiabetic, antimicrobial, and anti-inflammatory properties are being studied for their therapeutic potential. The main objective of this study is to formulate and evaluate polyherbal antidiabetic tablets using locally collected plant materials-mango leaves (Mangifera indica), garlic (Allium sativum), cinnamon (Cinnamomum zeylanicum), and flaxseeds (Linum usitatissimum). The plant materials were cleaned, dried, and powdered. The key active ingredient from mango leaves was extracted using ethanol and stored for further use. The polyherbal tablets were then prepared and evaluated based on parameters such as weight variation, hardness, friability, thickness, and disintegration time.