Nephroprotective herbs: an updated review

Radhika Sharma; Ajeet Pal Singh; Amar Pal Singh

doi:10.46956/ijihd.v10i1.685

Radhika Sharma Department of Pharmacy, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Ajeet Pal Singh Department of Pharmacy, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Amar Pal Singh Department of Pharmacy, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

DOI https://doi.org/10.46956/ijihd.v10i1.685

Abstract

Many natural products, medicinal plants, and food sources have been evaluated as possible nephroprotective agents. When developing an appropriate treatment to treat a range of kidney problems, medicinal plants can be a valuable source for new molecules with potential applications. Medicinal plants contain many complex molecules that impart their medicinal properties. Because medicinal plants have relatively high concentrations of phytoconstituents, bioactive compounds including, but not limited to, alkaloids, phenols, steroids, and flavonoids demonstrate significant nephroprotective properties to nephrotoxicity. The objective of the current review was to highlight a few of the contemporary medicinal herbs that have been evaluated for nephroprotective properties.

Keywords: Nephrotoxicity, herbal plants, medicinal uses, phytoconstituents, renal illness

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References

1. Xu X, Zhu R, Ying J, Zhao M, Wu X, Cao G, Wang K. Nephrotoxicity of herbal medicine and its prevention. Frontiers in pharmacology. 2020 Oct 15; 11:569551.
2. Ferguson MA, Vaidya VS, Bonventre JV. Biomarker of Nephrotoxic acute kidney injury. Toxicology. 2008.245(3).182-93.
3. Cordeiro MC, Kaliwal BB. Hepatoprotective and nephroprotective activity of bark extract of Brideliaretusaspreng in CCL4 treated female mice.2011:2 (1), 22–30.
4. Durbar US. Nature's Cure for the Management of Drug Induced Nephrotoxicity. Research Journal of Pharmacy and Technology. 2015;8(11):1593-7.
5. Bharati D, Goyal S, Bose A. Nephroprotective activity of dichloromethane extract of leaves of Alstoniascholaris Linn. in gentamycin induced nephrotoxicity in rats: preventive study. Research Journal of Pharmacy and Technology. 2021 Feb 1;14(2):1055-8.
6. Abhirama BR, Rajagopal SS, Nanjan M. Nephroprotective effect of ethanol extract of Biophytumsensitivum (Linn.) DC in cisplatin-induced experimental renal damage in rats. Research Journal of Pharmacy and Technology. 2017;10(6):1772-9.
7. Yadav AV, Momin MB, Panjwani A. Renoprotective effect of Corallocarpusepigaea in Nephropathy in Wistar Rats. Research Journal of Pharmacy and Technology. 2020;13(7):3163-8.
8. Askari H, Enayati N, Ahmadian-Attari MM, Bakhtiyari M, Alirezaei A. Protective effects of Descurainiasophia against gentamicin induced nephrotoxicity in rats. Iranian Journal of Pharmaceutical Research: IJPR. 2021;20(1):40.
9. Rethinam G, Duraiswamy A, Reddy GD, Elankani P, Srinivasan SK. Nephroprotective effect of SphaeranthusamaranthoidesBurm f.: Sivakaranthai (a Siddha Kayakalpa drug) against gentamicin induced nephrotoxicity. Advances in traditional medicine. 2021:1-0.
10. Kpemissi M, Eklu-Gadegbeku K, Veerapur VP, Potârniche AV, Adi K, Vijayakumar S, Banakar SM, Thimmaiah NV, Metowogo K, Aklikokou K. Antioxidant and nephroprotection activities of Combretummicranthum: A phytochemical, in-vitro and ex-vivo studies. Heliyon. 2019 Mar 1;5(3).
11. Danish TK. Nephroprotective Activity of TamarindusIndica Linn Fruit Extract on Cisplatin Induced Nephrotoxicity in Rats (Doctoral dissertation, The Erode College of Pharmacy and Research Institute, Erode).
12. Amarasiri AM, Attanayake AP, Jayatilaka KA, Mudduwa LK. Acute nephroprotective and antioxidant activities of aqueous leaf extract of Plectranthusamboinicus (Roxb.) grown in Sri Lanka. J. Pharmacogn. Phytochem. 2018;7(4):155-61.
13. Ahmad R, Mujeeb M, Ahmad A, Anwar F. Ameliorative effect of Aeglemarmelos leaves extract against cisplatin-induced nephrotoxicity and oxidative stress. Bangladesh Journal of Pharmacology. 2016 Jan 1;11(1).
14. Kumar A, D'Souza P, Bhargavan D. Evaluation of renal protective activity of Adhatodazeylanica (medic) leaves extract in wistar rats. Journal of Health and Allied Sciences NU. 2013 Dec;3(04):045-56.
15. Shirwaikar A, Issac D, Malini S. Effect of Aervalanata on cisplatin and gentamicin models of acute renal failure. Journal of ethnopharmacology. 2004 Jan 1;90(1):81-6.
16. Shiju TM, Rajkumar R, Rajesh NG, Viswanathan P. Aqueous extract of Allium sativum L bulbs offer nephroprotection by attenuating vascular endothelial growth factor and extracellular signal-regulated kinase-1 expression in diabetic rats.
17. Sawardekar SB, Patel TC. Evaluation of the effect of Boerhaviadiffusa on gentamicin-induced nephrotoxicity in rats. Journal of Ayurveda and integrative medicine. 2015 Apr;6(2):95.
18. Anwar Ibrahim DA, NomanAlbadani R. Evaluation of the potential nephroprotective and antimicrobial effect of Camellia sinensis leaves versus Hibiscus sabdariffa (in vivo and in vitro studies). Advances in Pharmacological and Pharmaceutical Sciences. 2014;2014(1):389834.
19. Tahir M, Sadiq N, Ahmed S, Ali A, Rajpoot NN, Riaz U. Effects of aqueous and methanolic extracts of cichoriumintybus seeds on gentamicin induced nephrotoxicity in rats. Journal of Islamic International Medical College (JIIMC). 2018 Dec 1;13(4):184-8.
20. Sarumathy K, Rajan MD, Vijay T, Jayakanthi J. Evaluation of phytoconstituents, nephro-protective and antioxidant activities of Clitoriaternatea. Journal of Applied Pharmaceutical Science. 2011 Jul 30(Issue):164-72.
21. Thuwaini MM, Kadhem HS, Al-Dierawi KH. Nephroprotective activity of Matricaria chamomile and Curcuma longa aqueous extracts on tetracyclines-induced nephrotoxicity in albino rats. Inter. J. Pharmacy Ther. 2016;7(4):161-7.
22. Thomas P, Gururaja MP, Joshi H, Prasannashama K, D'Souza U, Chacko N, Raj KC, Rajesh KS. Ameliorative Potential of Ecliptaalba on Gentamycin Induced Renal Toxicity in Rats. Research Journal of Pharmacy and Technology. 2019;12(1):192-6.
23. Nassan MA, Soliman MM, Aldhahrani A, Althobaiti F, Alkhedaide AQ. Ameliorative impacts of Glycyrrhizaglabra root extract against nephrotoxicity induced by gentamicin in mice. Food science & nutrition. 2021 Jul;9(7):3405-13.
24. kanniparambil Xavier S, Haneefa SM, Anand DR, Maheshwari R, Shreedhara CS, Setty MM. Antioxidant and nephroprotective activities of the extract and fractions of HomonoiaripariaLour. Pharmacognosy magazine. 2017 Jan;13(49):25.
25. Pramod K, Devala RG, Ramachandra SS. Nephroprotective and nitric oxide scavenging activity of tubers of Momordicatuberosa in rats. Avicenna Journal of Medical Biotechnology. 2011 Apr;3(2):87.
26. Palani S, Raja S, Naresh R, Senthil Kumar B. Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthusamboinicus on acetaminophen-induced nephrotoxic rats. Toxicology Mechanisms and Methods. 2010 May 1;20(4):213-21.
27. Yadav HN, Sharma US, Singh S, Gupta YK. Effect of Tribulusterrestris in mercuric chloride-induced renal accumulation of mercury and nephrotoxicity in rat. Journal of Advanced Pharmaceutical Technology & Research. 2019 Jul 1;10(3):132-7.
28. Hussain T, Gupta RK, Sweety K, Eswaran B, Vijayakumar M, Rao CV. Nephroprotective activity of Solanumxanthocarpum fruit extract against gentamicin–induced nephrotoxicity and renal dysfunction in experimental rodents. Asian Pacific journal of tropical medicine. 2012 Sep 1;5(9):686-91.
29. Kadir FA, Kassim NM, Abdulla MA, Yehye WA. Effect of oral administration of ethanolic extract of Vitexnegundo on thioacetamide-induced nephrotoxicity in rats. BMC complementary and alternative medicine. 2013 Dec;13:1-8.