Review on tanacetum parthenium
Abstract
Tanacetum parthenium (feverfew) is a traditional medicinal herb widely used for its therapeutic properties, particularly in the prevention and management of migraines. This review explores the botanical characteristics, phytochemical composition, pharmacological activities, and therapeutic applications of T. parthenium. Its bioactive compounds, parthenolide, exhibit potent anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising agent for managing a variety of chronic conditions, including arthritis, neurodegenerative diseases, and cancer. The mechanisms of action involve modulation of inflammatory pathways, inhibition of prostaglandin synthesis, and reduction of oxidative stress. Despite its potential, challenges such as variability in chemical composition, safety concerns, and limited clinical trials hinder its integration into mainstream medicine. Future research should focus on standardizing formulations, conducting clinical trials, and exploring novel therapeutic applications. This review underscores the importance of T. parthenium as a versatile herbal remedy with significant potential in modern healthcare, provided its limitations are addressed.
Keywords:
Tanacetum parthenium, Anti-inflammatory, Migraine, antioxidant, Microbial Degradation
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References
Anil Pareek, Manish Suthar, Garvendra S. Rathore and Vijay Bansal. Feverfew (Tanacetum parthenium L.): A systematic review. International journal of agriculture and biology. 2011; volume 5, issue 9. PP. 103-110.
2. Zahra Izadi, Mahmood Esna-Ashari, Khosro Piri, And
Poorandokht Davoodi. Chemical composition and antimicrobial activity of feverfew (Tanacetum Parthenium) Essential oils. International journal of agriculture and biology. 2024; volume12, issue5, pp. 759-763.
3. H.M. Tankol, D.J. Carrier, S. Sokhansanj and T.G. Crowe. Drying of feverfew (Tanacetum Parthenium L.) Journal of agricultural and bioresource. 2005; volume 47, 114-116.
4. Farzaneh Pourianezhad1, sara Tahmasebi1, Vahid Abdusil, Somayeh Nikfar, Mahmoud Mirhoseini. Review on feverfew, a valuable medicinal plan. Journal of Herbmed pharmacology. 2016; 5(2); 45-49.
5. E Ernst, MH Pittler. The efficacy and safety of feverfew (Tanacetum parthenium L.). Journal of Public Health Nutrition: 2006;3(4A), 509-514.
6. Danish i,S.Sokhansanj.A. Novel Approaches to Feverfew (Tanacetum Prthenium). Journal of med plants .2023;1(1):120-127 .
7. Naveen K Jain, Shrinivas K Kulkarni. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. Journal of Ethnopharmacology. 1999
; 68(15): 251-259.
8. Ali Kashkooe, Atefeh Jalali, Mohammad M. Zarshenas; Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.)Sch.Bip.:Acomprehensive Literature Review, Biomedicines 2024, 12(10), 2297.
9. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet. 1985;1:1071.
10. Mahajan, V.K.; Sharma, V.; Gupta, M.; Chauhan, P.S.; Mehta, K.S.; Garg, S. Parthenium dermatitis: Is parthenolide an effective choice for patch testing? Contact Dermat. 2014, 70, 340–343.
11. Sumner H, Salan U, Knight DW, Hoult JR. Inhibition of 5-lipoxygenase and cyclo- oxygenase in leukocytes by feverfew.Involvement of sesquiterpene lactones and other components. BiochemPharmacol. 1992;43:2313–20.
12. Jackson B, McDonald RL. Magic and Medicine of Plants. In: Dobelis IN, editor. Pleasantville, NY: Reader's Digest Assoc. 1986.
13. Johnson, E.S. Patients who chew chrysanthemum leaves. MIMS Mag. 1983, 15(32), 24.
14. Johnson, s. Feverfew. A Traditional Herbal Remedy for migraine and Arthritis; Sheldon Press; London, 1984.
15. Vinesh Kumar, Devendra Tyagi, Chemical Composition and Biological Activities of Essential Oils of Genus Tanacetum - a review. Journal of Pharmacognosy and Phytochemistry 2013; 2 (3): 159-163.
16. Abad, M.; Bermejo, P.; Villar, A. An approach to the genus Tanacetum, L. (Compositae): Phytochemical and pharmacological review. Phytother. Res. 1995, 9, 79– 92.
17. Rateb, M.; El-Gendy, A.; El-Hawary, S.; El-Shamy, A. Phytochemical and biological studies on the different organs of Tanacetum parthenium L. cultivated in Egypt. J. Med. Plants 2008, 7, 8–22.
18. Yao, Y.; Song, L.; Zuo, Z.; Chen, Z.; Wang, Y.; Cai, H.; Gu, Y.; Lv, Z.; Guan, J.;
Chen, R.; et al. Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling. Phytomedicine 2024, 134, 155976.
19. Williams CA, Harborne JB, Geiger H, Hoult JRS. Phytochemistry 1997; 51:417, 1999.
20. Bandoniene D, Pukalskas A, Venskutonis PR, Gruzdine D. Food Res Intl 2000; 33:785- 791.
21. Kalodera Z, Pepeljnjak S, Blazevic N, Petrak T. Chemical composition and antimicrobial activity of Tanacetum parthenium essential oil. Pharmazie 1997; 52(11):885.
22. Goren N, Jakopovic J, Topal S. Phytochemistry 1990; 29(5): 1467.
23. Goren N, Tahtaskal E, Pezzuto JM, Cordel GA, Schwarz B, Proksch P. Phytochemistry 1994; 369(2):389.
24. Moscano, F.; Guiducci, M.; Maltoni, L.; Striano, P.; Ledda, M.G.; Zoroddu, F.; Raucci, U.; Villa, M.P.; Parisi, P. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital. J. Pediatr. 2019, 45, 36.
25. Tassorelli, C.; Greco, R.; Morazzoni, P.; Riva, A.; Sandrini, G.; Nappi, G. Parthenolide is the component of Tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: Studies in an animal model of migraine. Cephalalgia 2005, 25, 612–621.
26. Cárdenas, J.; Reyes-Pérez, V.; Hernández-Navarro, M.D.; Dorantes-Barrón, A.M.; Almazán, S.; Estrada-Reyes, R. Anxiolytic-and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice. J. Ethnopharmacol. 2017, 200, 22–30.
27. Soni, U.K.; Jenny, L.; Hegde, R.S. IGF-1R targeting in cancer—does sub-cellular localization matter? J. Exp. Clin. Cancer Res. 2023, 42, 273.
28. Collier HO, Butt NM, McDonald WJ, Saeed SA. Extract of feverfew inhibits prostaglandin biosynthesis. Lancet. 1980;2:922–3.
29. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet. 1985;1:1071–4.
30. Neill LA, Barrett ML, Lewis GP. Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect. Br J Clin Pharmacol. 1987;23:81–3
31. Gokhan Zengin a 1, Aleksandra Cvetanović b 1, Uroš Gašić, Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.), Industrial Crops and ProductsVolume 146, April 2020, 112202.
32. ASAE ,St. Joseph, MI: ASABE.. 2001b. Standard S448 - Thin-layer drying of grains and crops. In ASAE Standards 2001, 45th edition, 605 - 607.
33. Hansen, R.C., H.M. Keener and H.N. Elsohly. 1993. Thin-layer drying of cultivated taxus clippings. Transactions of the ASAE 36: 1873-1877.
34. Palevitch D. Feverfew (Tanacetum parthenium) as prophylactic treatment for migraine: A double-blind placebo-controlled study. Phytother Res. 1997;11:508–11.
35. Ataollahi, M.; Akrami, E.; Kalani, M.; Zarei, M.; Chijan, M.R.; Sedigh-Rahimabadi, M.; Alipanah, H. Evaluation of anticoagulant and inflammatory effects of Tanacetum parthenium (L.) in a randomized controlled clinical trial. J. Herb. Med. 2022, 36, 100613.
36. Nanda, A.; Wasan, A. Allergic contact dermatitis to parthenolide. J. Allergy Clin. Immunol. Pract. 2016, 4, 993–994.
2. Zahra Izadi, Mahmood Esna-Ashari, Khosro Piri, And
Poorandokht Davoodi. Chemical composition and antimicrobial activity of feverfew (Tanacetum Parthenium) Essential oils. International journal of agriculture and biology. 2024; volume12, issue5, pp. 759-763.
3. H.M. Tankol, D.J. Carrier, S. Sokhansanj and T.G. Crowe. Drying of feverfew (Tanacetum Parthenium L.) Journal of agricultural and bioresource. 2005; volume 47, 114-116.
4. Farzaneh Pourianezhad1, sara Tahmasebi1, Vahid Abdusil, Somayeh Nikfar, Mahmoud Mirhoseini. Review on feverfew, a valuable medicinal plan. Journal of Herbmed pharmacology. 2016; 5(2); 45-49.
5. E Ernst, MH Pittler. The efficacy and safety of feverfew (Tanacetum parthenium L.). Journal of Public Health Nutrition: 2006;3(4A), 509-514.
6. Danish i,S.Sokhansanj.A. Novel Approaches to Feverfew (Tanacetum Prthenium). Journal of med plants .2023;1(1):120-127 .
7. Naveen K Jain, Shrinivas K Kulkarni. Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. Journal of Ethnopharmacology. 1999
; 68(15): 251-259.
8. Ali Kashkooe, Atefeh Jalali, Mohammad M. Zarshenas; Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.)Sch.Bip.:Acomprehensive Literature Review, Biomedicines 2024, 12(10), 2297.
9. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet. 1985;1:1071.
10. Mahajan, V.K.; Sharma, V.; Gupta, M.; Chauhan, P.S.; Mehta, K.S.; Garg, S. Parthenium dermatitis: Is parthenolide an effective choice for patch testing? Contact Dermat. 2014, 70, 340–343.
11. Sumner H, Salan U, Knight DW, Hoult JR. Inhibition of 5-lipoxygenase and cyclo- oxygenase in leukocytes by feverfew.Involvement of sesquiterpene lactones and other components. BiochemPharmacol. 1992;43:2313–20.
12. Jackson B, McDonald RL. Magic and Medicine of Plants. In: Dobelis IN, editor. Pleasantville, NY: Reader's Digest Assoc. 1986.
13. Johnson, E.S. Patients who chew chrysanthemum leaves. MIMS Mag. 1983, 15(32), 24.
14. Johnson, s. Feverfew. A Traditional Herbal Remedy for migraine and Arthritis; Sheldon Press; London, 1984.
15. Vinesh Kumar, Devendra Tyagi, Chemical Composition and Biological Activities of Essential Oils of Genus Tanacetum - a review. Journal of Pharmacognosy and Phytochemistry 2013; 2 (3): 159-163.
16. Abad, M.; Bermejo, P.; Villar, A. An approach to the genus Tanacetum, L. (Compositae): Phytochemical and pharmacological review. Phytother. Res. 1995, 9, 79– 92.
17. Rateb, M.; El-Gendy, A.; El-Hawary, S.; El-Shamy, A. Phytochemical and biological studies on the different organs of Tanacetum parthenium L. cultivated in Egypt. J. Med. Plants 2008, 7, 8–22.
18. Yao, Y.; Song, L.; Zuo, Z.; Chen, Z.; Wang, Y.; Cai, H.; Gu, Y.; Lv, Z.; Guan, J.;
Chen, R.; et al. Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling. Phytomedicine 2024, 134, 155976.
19. Williams CA, Harborne JB, Geiger H, Hoult JRS. Phytochemistry 1997; 51:417, 1999.
20. Bandoniene D, Pukalskas A, Venskutonis PR, Gruzdine D. Food Res Intl 2000; 33:785- 791.
21. Kalodera Z, Pepeljnjak S, Blazevic N, Petrak T. Chemical composition and antimicrobial activity of Tanacetum parthenium essential oil. Pharmazie 1997; 52(11):885.
22. Goren N, Jakopovic J, Topal S. Phytochemistry 1990; 29(5): 1467.
23. Goren N, Tahtaskal E, Pezzuto JM, Cordel GA, Schwarz B, Proksch P. Phytochemistry 1994; 369(2):389.
24. Moscano, F.; Guiducci, M.; Maltoni, L.; Striano, P.; Ledda, M.G.; Zoroddu, F.; Raucci, U.; Villa, M.P.; Parisi, P. An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache. Ital. J. Pediatr. 2019, 45, 36.
25. Tassorelli, C.; Greco, R.; Morazzoni, P.; Riva, A.; Sandrini, G.; Nappi, G. Parthenolide is the component of Tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: Studies in an animal model of migraine. Cephalalgia 2005, 25, 612–621.
26. Cárdenas, J.; Reyes-Pérez, V.; Hernández-Navarro, M.D.; Dorantes-Barrón, A.M.; Almazán, S.; Estrada-Reyes, R. Anxiolytic-and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice. J. Ethnopharmacol. 2017, 200, 22–30.
27. Soni, U.K.; Jenny, L.; Hegde, R.S. IGF-1R targeting in cancer—does sub-cellular localization matter? J. Exp. Clin. Cancer Res. 2023, 42, 273.
28. Collier HO, Butt NM, McDonald WJ, Saeed SA. Extract of feverfew inhibits prostaglandin biosynthesis. Lancet. 1980;2:922–3.
29. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet. 1985;1:1071–4.
30. Neill LA, Barrett ML, Lewis GP. Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect. Br J Clin Pharmacol. 1987;23:81–3
31. Gokhan Zengin a 1, Aleksandra Cvetanović b 1, Uroš Gašić, Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.), Industrial Crops and ProductsVolume 146, April 2020, 112202.
32. ASAE ,St. Joseph, MI: ASABE.. 2001b. Standard S448 - Thin-layer drying of grains and crops. In ASAE Standards 2001, 45th edition, 605 - 607.
33. Hansen, R.C., H.M. Keener and H.N. Elsohly. 1993. Thin-layer drying of cultivated taxus clippings. Transactions of the ASAE 36: 1873-1877.
34. Palevitch D. Feverfew (Tanacetum parthenium) as prophylactic treatment for migraine: A double-blind placebo-controlled study. Phytother Res. 1997;11:508–11.
35. Ataollahi, M.; Akrami, E.; Kalani, M.; Zarei, M.; Chijan, M.R.; Sedigh-Rahimabadi, M.; Alipanah, H. Evaluation of anticoagulant and inflammatory effects of Tanacetum parthenium (L.) in a randomized controlled clinical trial. J. Herb. Med. 2022, 36, 100613.
36. Nanda, A.; Wasan, A. Allergic contact dermatitis to parthenolide. J. Allergy Clin. Immunol. Pract. 2016, 4, 993–994.
Published
17/03/2025
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N. Bandi, R. Sarvepalli, P. Venugopalaiah, and P. C. Y, “Review on tanacetum parthenium”, Int J Indig Herb Drug, vol. 10, no. 1, pp. 7-13, Mar. 2025.
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