Anti-inflammatory activity of medicinal plants: A review
Abstract
Medicinal plants continue to be of interest for several reasons including lack of availability of a satisfactory therapy of several clinical conditions inflammatory disorders being one of them. Inflammation is a defensive response that is characterized by redness, pain, heat, and swelling and loss of function in the injured area. Inflammation is body’s nonspecific internal systems of defense, the response of a tissue to an accidental cut is similar to the response that results from other types of tissue damage, caused by burns due to heat, radiation, bacterial or viral invasion. Anti-inflammatory drugs like NSAIDs used to reduce the swelling and pain of inflammation. Long-term uses of NSAID cause adverse side effects and damage human biological system such as liver, gastrointestinal tract etc. The management of inflammation related diseases is a real issue in the rural community; the population in these areas uses many alternative drugs such as substances produced from medicinal plants. Herbal products from medicinal plants are playing a major role to cure many diseases associated with the inflammation. Many conventional drugs are available in the market to treat the inflammation which produces various side-effects. Due to these side-effects there is need for the search of newer drugs with less or no side-effects. In this review an attempt has been made to investigate the anti-inflammatory activity of some medicinal plants. It can be helpful to researchers in the study of anti-inflammatory substances from plants. This also may serve as a guide for pharmacologists studying the mechanisms of action and anti-inflammatory effects of these substances.
Keywords:
Medicinal plants, Phytoconstituents, Pharmacology, Anti-inflammatory activity
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References
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20. Iwueke AV, Nwodo OF, Okoli C. Evaluation of the anti-inflammatory and analgesic activities of Vitex doniana leaves. Academic J 2006; 1684-5315.
21. Das S, Das S, Das MK, Basu SP. Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats. J Pharm Sci Res 2009; 1: 123-126.
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23. Abdullahi N, Ilyas, Ibrahim, H. Evaluation of analgesic and anti-inflammatory activities of n-butanol phase of the leaves extract of Microtrichia perotitii DC (Asteraceae). J Med Plant Res 2010; 4: 72.
24. Vijaya KS, Sankar P, Varatharajan R. Anti-inflammatory activity of roots of Achyranthes aspera. Pharm Biol 2009; 47: 973-975.
25. Owoyele BV, Olaleye SB, Oke JM, Elegbe RA. Anti-inflammatory and analgesic activities of leaf extracts of Landolphia owariensis. Afr J Biomed Res 2001; 4: 131-133.
26. Patil AS, Patel NC, Shah MH, Shah VN. Evaluation of anti-inflammatory activity of fruits Trapa natans linn. J Pharm Res Develop 2011; 3: 97-102
27. Ravi R, Ritesh J, Narendra M, Prshant A, Khadbadi SS. Antiinflammatory action of Abutilon indicum sweet leaves by HRBC membrane stabilization. Res J Pharm Tech 2009; 2: 974-3618.
28. Arunachalam GN, Subramanian GP, Pazhani, Ravichandran V. Anti-inflammatory activity of methanolic extract of Eclipta prostrate. Afr J Pharm Pharmacol 2009; 3: 097-100.
29. Warrier PK, Nambier VPK, Raman KC. Indian Medicinal plants: A Compendium of 500 species 1994; 2: 180.
30. Parmar NS, Ghosh MN. Anti-inflammatory activity of Gossypin a bioflavonoid isolated from Hibiscus vitifolius Linn. Indian J Pharmacol 1978; 10: 277-293.
31. Sashida Y, Kubo S, Mimaki Y, Nikaido T, Ohmoto T. Steroidal saponins from Smilax riparia and S. china. Phytochemistry 1992; 31: 2439–2443.
32. Chattopadhyay RR, Chattopadhyay RN, Maitra SK. Possible mechanism of anti-inflammatory activity of Azadirachta indica leaf extract. Indian J Pharmacol 1993; 25: 99-100.
33. Sarkarm D, Dutta A, Das M, Sarka, K, Mandal C, Chatterjee M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian J Pharmacol 2005; 37: 371-375.
34. Speroni E, Cervellati R, Costa S, Guerra MC, Utan A, Govoni P. Effects of differential extraction of Verbena officinallis on rat models of inflammation, cicatrisation and gastric damage. Planta Medica 2007; 73; 227-235.
35. Ilavarasan R, Mallika M, Venkataraman S. Anti-inflammatory and antioxidant activities of Cassia fistula Linn bark extracts. Afr J Tradit Complementary Altern Med 2005; 1: 70-85.
36. Verma S, Ojha S, Mohammad R. Anti-inflammatory activity of Aconitum heterophyllum on cotton pellet-induced granuloma in rats. J Med Plant Res 2010; 4: 1566-1569.
37. Ahmed MM, Qureshi S, Al-bekairi AM, Shah AH, Rao RM, Qazi NS. Anti-inflammatory activity of Caralluma tuberculata alcoholic extract. Fitoterapia 1993, 64: 359-362
38. Vinha AF, Soares MO, Castro A, Santos A, Machado M. Phytochemical characterization and radical scavenging activity of aqueous extracts of medicinal plants from Portugal 2011; 2: 335-347.
39. Das BK, Fatema UK, Hossain MS, Rahman R, Akbar MA. Analgesic and anti-inflammatory activities of the fruit extract of Ampelocissus latifolia (Roxb) on laboratory animals. Br J Pharm Res 2014; 4: 1477-1485.
40. Konan G, Edwige AA, Dodehe Y, Allico JD, Adou FY, Jean DN, Houphouet FY. Evaluation of anti-inflammatory activities of aqueous and ethanolic extracts of gomphrena 2015; 5: 127-134.
41. Benni JM, Jayanthi MK, Suresha RN. Evaluation of the antiinflammatory activity of Aegle marmelos (Bilwa) root. Indian J Pharmacol 2011, 43: 393-397.
42. Ilango K, Maharajan G, Narasimhan S. Anti-nociceptive and anti-inflammatory activities of Azadirachta indica fruit skin extract and its isolated constituent azadiradione. Nat Prod Res 2012; 27: 1463-1467.
43. Saha A, Ahmed M. The analgesic and anti-inflammatory activities of the extract of Albizia Lebbeck in animal model. Pak J Pharm Sci 2009, 22: 74-77.
44. Chavan M, Wakte P, Shinde D. Analgesic and antiinflammatory activity of caryophyllene oxide from Annona squamosa L. bark. Inter J Phytotherapy Phytopharmacol 2009; 17: 149-151.
45. Goldberg AS, Mueller EC, Eigen E, Desalva SJ. Isolation of the anti-inflammatory principles from Achillea millefolium (Compositae). J Pharma Sci 1996; 58: 938-941.
46. Vaidya ADB, Raut AA, Vaidya RA. Abrus precatorius, Gaertin- An Ayurvedic potent phytomedicine. J Assoc Physician India 2005; 53:739-740.
47. Jia Q, Nichols TC, Rhoden E, Waite S. Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia 2002; US Patent no. 7108868.
48. Burnett BP, Jia Q, Zhao Y, Levy RM. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food 2007; 10: 442-451.
49. Jia Q. Generating and screening a natural product library for cyclooxygenase & lipoxygenase dual inhibitors. Studies Nat Prod Chem 2003; 29: 643-718.
50. Ismail S, Asad M. Immunomodulatory activity of Acacia catechu. Indian J Physiol Pharmacol. 2009; 53: 25-33.
51. Arulmozi S, Mazumder PM, Ashok P, Narayanan LS. Pharmacological activities of Alstonia scholaris Linn. – A review. Pharmacog Rev 2007; 1: 163-170.
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28/02/2018
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[1]
S. S. Sandeep Sahu and A. C. Amrita Chourasia, “Anti-inflammatory activity of medicinal plants: A review”, Int J Indig Herb Drug, pp. 11-20, Feb. 2018.
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Review Articles
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