Antioxidant activity of different extracts of fruits of Morus alba

Somayeh Afsah Vakili Somayeh Afsah Vakili; Syed F Syed F

Somayeh Afsah Vakili Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, Bangalore-560070, Karnataka, India
Syed F Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, Bangalore-560070, Karnataka, India

Abstract

Objective: The current scrutiny was designed to investigate the antioxidant activity of aqueous and ethanol extracts of Morus alba.

Methods: Antioxidant evaluation was done by screening of hydroxyl radical scavenging through deoxyribose assay and estimatedlipid peroxide level in liver and brain homogenate of rat’s tissues by thiobarbituric acid methods.

Results: The overall antioxidant activity of Morus alba was found to be considerable by diminishing in hydroxyl radical activity and level of lipid peroxidation. IC50 values of aqueous and ethanol extracts of Morus alba was found to be 766 μg/ml and 539 μg/ml respectively for hydroxyl radical scavenging activity. IC50 values of aqueous and ethanol extracts of Morus alba was found to be 791 μg/ml and 724 μg/ml respectively for lipid peroxidation assay in liver homogenates. Fifty percentage of inhibition concentration was perceived to be 592 μg/ml and 478 μg/ml for aqueous and ethanol extracts of Morus alba respectively for lipid peroxidation in brain homogenates.

Conclusion: This investigation recommends that Morus alba extracts display potential antioxidant activity which can be useful in herbal formulation as nutritional supplements and it can help fight against ageing, cancer, and chronic diseases like cardiovascular disease.

Keywords: Antioxidant activity, hydroxyl radical scavenging, lipid peroxidation, Morus alba

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