Root powder extract, phytochemical studies & preparation of herbal formulation tinospora cordifolia asava
Abstract
Asava, a traditional formulation in Ayurveda, is renowned for its superior preservation and enhanced therapeutic efficacy. This phenomenon is largely attributed to the intricate process of fermentation facilitated by a consortium of microbes. Microbial activity not only extends the shelf-life of Asava but also transforms its constituent ingredients into potent therapeutics through biotransformation. The alcohol-aqueous milieu generated during fermentation not only preserves the formulation but also facilitates improved drug delivery within the body. This milieu, predominantly produced by microbial action, acts as a medium for the potentization of drugs, enhancing their bioavailability and efficacy. Moreover, the biotransformation mediated by native microbes leads to the synthesis of novel compounds with enhanced therapeutic properties, thereby elevating the overall efficacy of Asava. The preservative properties inherent in these formulations, coupled with microbial-mediated potentization, underscore the significance of microbial fermentation in augmenting the therapeutic potential of Asava in Ayurveda.
Keywords:
Asava, Ayurveda, fermentation, microbial activity, therapeutic properties, preservation
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References
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1. J. Evid.BasedIntergr. Med. 2014;19:216-219. Doi: 10.1177/2156587214533346.
2. Mittal, J, M. M., &Batra, A, (2014). Tinospora cordifolia: a multipurpose medicinal
3. plant-A plant. Journal of medicinal plants, 2(2).
4. Joshi, S. P., Kawale, S. S., Kasture, K. A., Deshmane, H. C., & Pingale, P. POTENTIAL AND THERAPEUTIC BENEFITS OF TINOSPORA CORDIFOLIA .
5. Herbal Pharmacognosy: Kristian Leisegang, in Herbal Medicine in Andrology, 2021. Science direct. Com. Medicine and dentistry pharmacognosy.
6. Background to Pharmacognosy: T. O. Elufioye, S, Badal in Pharmacognosy, 2017.Science direct. Com. Medicine and dentistry pharmacognosy.
7. Semwal DK, Mishra SP, Chauhan A, Semwal RB. Adverse health effects of tobacco and role of Ayurveda in their reduction. J Med Sci. 2015;15:139–46.
8. Sharma AK, Singh S, Singh H, Mahajan D, Kolli P, Mandadapu G, Kumar B, Kumar D, Kumar S, Jena MK. Deep insight of the pathophysiology of gestational diabetes mellitus. Cells. 2022 Aug 28;11(17):2672.
9. Jacqui W. Herbal products are often contaminated, study finds. BMJ2013; 347:f6138.
10. Jaswal S, Jena MK, Anand V, Jaswal A, Kancharla S, Kolli P, Mandadapu G, Kumar S, Mohanty AK. Critical review on physiological and molecular features during bovine mammary gland development: recent advances. Cells. 2022 Oct 21;11(20):3325.
11. Basisht G. Exploring progression of Ayurveda. Ayu. 2011;32:445–7.
12. Baghel MS. Need of new research methodology for Ayurveda. Ayu. 2011;32:3–4. [PubMed]
13. 12. Sharma PV, editor. Charaka Samhita of Agnivesha, Sutra Sthana, Ch. 11, Ver. 2. Varanasi: Choukhamba Orientalia; 1995. p. 114.
14. Patwardhan B. The quest for evidence-based Ayurveda: Lessons learned. Curr Sci. 2012;102:1406–17.
15. Morandi A, Tosto C, Sartori G, Roberti di Sarsina P. Advent of a link between Ayurveda and modern health science: The proceedings of the first international congress on ayurveda, “Ayurveda: The Meaning of Life-Awareness, Environment, and Health” March 21-22, 2009, Milan, Italy. Evid Based Complement Alternat Med 2011. 2011:929083.[PubMed]
16. Singh RH. Integrative Medicine, Special Monograph. New Delhi: ChoukhambaSurbharti; 2009.
17. Bhowmick TK, Suresh AK, Kane SG, Joshi AC, Bellare JR. Physicochemical characterization of an Indian traditional medicine, Jasada Bhasma: Detection of nanoparticles containing non-stoichiometric zinc oxide. J Nanopart Res. 2009;11:655–64.
18. Jena MK, Khan FB, Ali SA, Abdullah A, Sharma AK, Yadav V, Kancharla S, Kolli P, Mandadapu G, Sahoo AK, Rath PK. Molecular complexity of mammary glands development: a review of lactogenic differentiation in epithelial cells. Artificial cells, nanomedicine, and biotechnology. 2023 Dec 31;51(1):491-508.
19. Morandi A, Sartori G, Tosto C. Ayurveda-LaMedicinatradizionale Indiana. In: Giarrelli G, di Sarsina PR, Bilvestrini B, editors. Le Medicine Non Convenzionali in Italia – Storia, Problemi e Prospettive di Integrazione. Milan (Italy): Franco Angeli; 2007. pp. 291–309.
20. Mishra SP, Semwal DK, Chauhan A. Scenario of Ayurveda education in India: Some recommendations for development. University News – Association of Indian Universities. 2015;53:3–8.
21. Diwanay S, Gautam M, Patwardhan B. Cytoprotection and immunomodulation in cancer therapy. Curr Med Chem Anticancer Agents. 2004;4:479–90. [PubMed].
22. Cardellina JH., 2nd Challenges and opportunities confronting the botanical dietary supplement industry. J Nat Prod. 2002;65:1073–84. [PubMed].
23. Jamwal S, Jena MK, Tyagi N, Kancharla S, Kolli P, Mandadapu G, Kumar S, Mohanty AK. Proteomic Approaches to Unravel the Molecular Dynamics of Early Pregnancy in Farm Animals: An In-Depth Review. Journal of Developmental Biology. 2023 Dec 30;12(1):2.
24. S Shilpa and C. G. Venkatesha Murthy. Ayu. 2011 Jan-Mar; 32(1): doi: 10.4103/0974-8520.85716 PMCID: PMC3215408.85716| PMID: 22131752.
25. Das C., Ghosh G., Bose A., Das D., Indian J. Pharma. Sci., 2019, Vol. 81pg.396.
26. Naushad SM, Mandadapu G, Ramaiah MJ, Almajhdi FN, Hussain T. Mechanistic insights into TLR7-mediated clinical outcome in COVID-19 and the potential modulatory role of N-acetylcysteine.
27. Anonymous. Pharmaceutical standards of Ayurvedic Formulations. Government of India. Ministry of Health and Family Walefare. Department of Health. New Delhi, 1987; 464-469.
28. Singh S, Kancharla S, Kolli P, Mandadapu G, Jena MK. In Silico Exploration of Phytochemicals as Potential Drug Candidates against Dipeptidyl Peptidase-4 Target for the Treatment of Type 2 Diabetes. Biomedical and Biotechnology Research Journal (BBRJ). 2023 Oct 1;7(4):598-607.
29. The Ayurvedic Pharmacopoeia of India, Government of India Ministry of Health and Family Welfare Department of Indian System of Medicine and Homoeopathy, Part-1, 2nd edition, 2003; 34-101.
30. Naushad SM, Mandadapu G, Ramaiah MJ, Almajhdi FN, Hussain T. The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants. Scientific Reports. 2023 Aug 11;13(1):13078.
31. in Ayurveda and Pharmacy, 2011; 2(2): 665-669.
32. Valiathan MS, Thatte U. Ayurveda: The time to experiment. International journal of Ayurveda research, 2001; 1(1): 3-4.
33. Namita P, Rawat M, Medicinal Plants Used as Antimicrobial agents: Review, International journal of research in Pharmacy, 2012; (3)1: 31-40.
34. Chamundeeswari D., Kanimozhi P., Vasanthkumar R., Sri Ramachandra J. Med. 2007, Vol. 2 pg. 39
35. Panda P., Das B., Sahu D.S., Meher S. K., Bhuyna G. C., Das B. K., Rao M. M. Talia Kalpana (Medicated oil) in Ayurveda, Res. J. Pharmacol. Pharmacodyn., 2016, Vol.81(pg.39-41).Satruhan, D. K. (2022). A REVIEW ON Tinospora cordifolia : BIOLOGICALAND MEDICINAL PROPERTIES. Journal of Pharmaceutical Negative Results,3929-3940.
36. Sharma, P., Dwivedee, B. P., Bisht, D., Dash, A. K., 7 Kumar, D. (2019). The Chemical Constituents and diverse pharmacological importance of Tinospora cordifolia. Heliyon, 5(9),
37. M.G. Rasul. (2011 December). Extraction, Isolation and Characterization of Natural Products from Medicinal Plants. International Journal of Basic Sciences and Applied Computing. 2(6), pp. 1-6.
38. M.D. Luque de Castro, C. Priego. (2010, April). Soxhlet extraction: past and panacea. J Chromatogr A.1217 (16), 2383–2389.
39. A medicinal plant: micropropagation and phytochemical screening of Tinospora cordifolia (Wild.) Miers ex Hook F & Thoms IJAPBC., 4 (2015), pp. 114-121.
40. Sayyad S. F., Randive D. S., Jagtap S. M., Chaudhari S. R. and Panda B. P., Preparation and evaluation of fermented Ayurvedic formulation: Arjunarishta, Journal of Applied Pharmaceutical Science, 2012; 02(05): 122-124.
41. Mishra AK, Gupta A, Gupta V, Sannd R, Bansal P, Asava and Aristha: An Ayurvedic Medicine – An Overview, International Journal of Pharmaceutical & Biological Archives, 2010; 1(1): 24–30.
42. Sayyad S. F., Randive D. S., Jagtap S. M., Chaudhari S. R. and Panda B. P., Preparation and evaluation of fermented Ayurvedic formulation: Arjunarishta, Journal of Applied Pharmaceutical Science, 2012; 02(05): 122-124.
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17/06/2024
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S. M, “Root powder extract, phytochemical studies & preparation of herbal formulation tinospora cordifolia asava”, Int J Indig Herb Drug, vol. 9, no. 2, pp. 1-7, Jun. 2024.
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