Enhancement of antidiabetic activity of curcumin rhizome extract using silver nanoparticles

Ashish Garg Ashish Garg; Sweta Garg Sweta Garg

Ashish Garg Department of Chemistry and Pharmacy, Rani Durgavati University, Jabalpur-482001, MP, India
Sweta Garg Department of Chemistry and Pharmacy, Rani Durgavati University, Jabalpur-482001, MP, India

Abstract

Objective: In this current work, for enhancing the effect of the antidiabetic potential of curcumin extracted from Curcuma longa Linn by encapsulating the extract of curcuminin in silver nanoparticles was aimed.

Methods: Curcumin was extracted from Curcuma longa by Soxhlet method.. Curcumin shows poor solubility and low absorption rate therefore its silver nanoparticles was formed to increase solubility, absorption as well as affectivity against diabetes. Various analytical methods and assay such as particle size, zeta potential and fourier transform infrared spectroscopy (FTIR), drug release and in vitro antidiabetic study on streptozotocin induced diabetic rats were employed for monitoring the formation of curcumin extract encapsulated silver nanoparticles.

Results: Presence of silver nanoparticles with an average size of 26.78 nm was revealed by particle size analyzer and zeta potential may obtain -4.68 mV. CSNPs (curumin extract encapsulated silver nanoparticles) were able to release 94.35% curcumin in 12 hrs whereas the plain curcumin extract was released 95.68% in 8 hrs.

Conclusion: The conclusion after the result obtained by in vitro antidiabetic activity, demonstrated that CSNPs inhibit the blood glucose level than plain curcumin. This work shows that curcumin rhizome extract encapsulated silver nanoparticles shows potential antidiabetic acitivity.

Keywords: Antidiabetic Activity, Fourier Transform Infra-Red Spectroscopy, Particle Size, Curcumin, Silver Nanoparticles

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