In-vitro antiurolithiatic activity of alcoholic and hydroalcoholic extracts of Kalanchoe pinnata leaves

Abu Sufiyan Chhipa Abu Sufiyan Chhipa; Priyanka Soni Priyanka Soni; Vishal Soni Vishal Soni

Abu Sufiyan Chhipa Department of Pharmacognosy, B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India
Priyanka Soni Department of Pharmacognosy, B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India
Vishal Soni Department of Pharmacognosy, B.R. Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India

Abstract

Objective: The objective of this research was to find the efficiency of alcoholic and hydroalcoholic extracts of Kalanchoe pinnata leaves in dissolution of calcium oxalate crystals by using in-vitro dissolution model. Methods: In-vitro dissolution model was prepared by using semipermeable membranes obtained from eggs that served as dissolution bags for the investigation. Dissolution bags containing calcium oxalate and different extracts were suspended in conical flasks containing TRIS buffer. Percentage dissolution of calcium oxalate by different extracts was evaluated by titrimetry. Results: Hydroalcoholic extract of leaves of Kalanchoe pinnata showed more dissolution of calcium oxalate as compared to alcoholic extract. Although the dissolution of calcium oxalate by hydroalcoholic extract was less than that of standard drug. Conclusion: Results obtained from this research work indicated promising effects of Kalanchoe pinnata leaves in dissolution of calcium oxalate. Extracts of Kalanchoe pinnata leaves can be used for the effective treatment of urolithiasis.
Keywords: , , , , ,

Keywords: Kalanchoe pinnata, Antiurolithiatic Activity, Calcium Oxalate, Hydroalcoholic Extract, Cystone

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