DEVELOPMENT AND EVALUATION OF FLOATING BEADS OF BACLOFEN AS A GASTRORETENTIVE DOSAGE FORM
Abstract
Gastro retentive delivery systems are designed to be retained in the stomach for a prolonged time and release their active ingredients and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal (GI) tract. The goal of any drug delivery system is to provide a therapeutic amount of drug to proper site in the body to achieve promptly and then maintain a desired drug concentration. Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant used for the relief of painful and uncomfortable muscle spasms caused by a variety of conditions. Twelve different formulation of Baclofen floating beads were successfully developed using emulsion solvent diffusion method. The beads had good yield and showed high, drug entrapment efficiency. The flow properties of beads were within the acceptable range and therefore would be easily filled into capsules.
Study concludes successfully delivery of Baclofen by the means of floating beads.
Keywords:
Gastro retentive delivery systems, floating beads, Baclofen
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References
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2. GÜNEŞM, KARAVANA SY, ALGIN YAPARE. Buccal drug delivery system: an overview about dosage forms and recent studies. Universal Journal of Pharmaceutical Research 2019; 4(6):69-74.
3. Chien YW. Rate control drug delivery systems: controlled release vs. sustained release. Med Prog Techn 1989; 15: 21-46.
4. Igwe J. Chibueze, Emenike IV, Oduola AR. Formulation and evaluation of Finasteride sustained-release matrix tablets using different rate controlling polymers. Universal Journal of Pharmaceutical Research 2016; 1(2): 15-18.
5. Mayavanshi AV, Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. J Pharm Tech 2008; 1(14): 345-348.
6. Andrew EC, Grace EA, Salome CA, Elochukwu A, Izuchukwu BC, Ejiofor UK, Lorrita CC, Godswill O. Evaluation of Metronidazole tablets formulated with different disintegrants usingmoisture activated dry granulation. Universal Journal of Pharmaceutical Research 2023; 8(3):34-39.
7. Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A review. Int J Pharm Res 2009; 1(3): 623-633.
8. Opeyemi OT, Adegbenro OO. Development and characterization of direct compressed matrix mini tablets of naproxen sodium. Universal Journal of Pharmaceutical Research 2018; 3(5): 63-68.
9. Mohamed HG, Dehghan Furquan N Khan. Gastroretentive drug delivery systems: a patent perspective. Int J Health Res 2009; 2(1): 23-44.
10. Shaikh SC, Sanap D, Bhusari DV, Jain S, Kochar PP, Sanchati VN. Formulation and evaluation of Ibuprofen gastro-retentive floating tablets. Universal Journal of Pharmaceutical Research. 2018; 3(4): 19-23.
11. Brennan JL, Leung JG, Gagliardi JP, Rivelli SK, Muzyk AJ: Clinical effectiveness of baclofen for the treatment of alcohol dependence: a review. Clin Pharmacol. 2013 Jul 3;5:99-107. doi: 10.2147/CPAA.S32434. Print 2013.
12. Chen K, Li HZ, Ye N, Zhang J, Wang JJ: Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro. Brain Res Bull. 2005 Oct 30;67(4):310-8. doi: 10.1016/j.brainresbull.2005.07.004.
13. Ertzgaard P, Campo C, Calabrese A: Efficacy and safety of oral baclofen in the management of spasticity: A rationale for intrathecal baclofen. J Rehabil Med. 2017 Mar 6;49(3):193-203. doi: 10.2340/16501977-2211.
14. Gattani YS, Kawtikwar PS, Sakarkar DM. Formulation and evaluation of gastro retentive multiparticulate drug delivery system of aceclofenac. Int J ChemTech Res 2009; 1(1): 1-10.
15. Ikechukwu UR, John Francis DE, Ambi AA. Development and evaluation of Ritonavir hollow microballoons for floating drug delivery. Universal Journal of Pharmaceutical Research 2017; 2(2): 8-11.
16. Talukder R, Fassihi R. Gastroretentive delivery systems: A mini review. Drug Dev. Ind. Pharm. 2004; 30(10):1019-1028.
17. Anyanwu NCJ, Adogo LY, Ajide B. Development and evaluation of in situ gelling gastroretentive formulations of Meloxicam. Universal Journal of Pharmaceutical Research 2017; 2(3): 10-13.
18. Bardonet PL, Faivre V, Pugh WJ, Piffaretti JC, Falson F. Gastroretentive dosage forms: Overview and special case of Helicobacter pylori. J Control Release. 2006; 111(1- 2):1-18.
19. Yusuf FS. Formulation and in-vitro evaluation of floating microballoons of stavudine. Universal Journal of Pharmaceutical Research 2016; 1(1): 8-11.
20. Singh RP, Rathore DS, Singh S. Formulation development and evaluation of floating multiparticulate drug delivery system of famotidine, prepared by ion gelation technique. Inventi Rapid: Pharm Tech. 2013; 1:1-7.
21. Kaur G, Paliwal S. Formulation and evaluation of etoricoxib microbeads for sustained drug delivery. Universal Journal of Pharmaceutical Research 2019; 4(1): 35-39.
22. Arun GTS, Krishnananda K, A.R. Shabaraya. Formulation and optimization of Aceclofenac gel. Res Pharm. 2013;3(1):14-22.
23. Agarwal P, Semimul A. A comprehensive review on sustained release matrix tablets: a promising dosage form. Universal Journal of Pharmaceutical Research 2018; 3(6): 49-54.
Published
23/10/2023
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[1]
P. Kumar, K. Kumar, A. Joshi, Ikram, and V. Rajput, “DEVELOPMENT AND EVALUATION OF FLOATING BEADS OF BACLOFEN AS A GASTRORETENTIVE DOSAGE FORM”, Int J Indig Herb Drug, vol. 8, no. 5, pp. 33-39, Oct. 2023.
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