The role of medicinal plants in rheumatoid arthritis-an updated review
Abstract
Rheumatoid arthritis (RA) is a debilitating, persistent autoimmune condition that affects by a variety of endogenous and external causes. It is distinguished by cartilage and bone deterioration. The present traditional allopathic treatment is costly and has negative side effects. Recently, some ethnopharmacological research on RA was published, including anti-RA properties and therapeutic targets of various dosage forms of Traditional Herbal Treatments (THMs). Given the increased herbalists' interest medicines among people suffers from rheumatoid arthritis, further research into their safety and efficacy is needed. The goal of this research was to carry out a comprehensive assessment of the evidence based on the use of herbal medications in the treatment of RA Randomised Clinical Trials (RCTs).Different chemical ingredients discovered in various herbal treatments have modest support for lowering pain, sensitive joint count, and stiffness. Herbal remedies were generally considered safe to use. More study is required to evaluate the effectiveness, safety, and potential medication interactions of the numerous herbal remedies advocated for RA.
Keywords:
herbal drugs, rheumatoid arthritis, treatment, randomisd control trials
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References
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24. Garrido-Suárez BB, Garrido G, Delgado R, Bosch F, Rabí MD. A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin. Molecules. 2010 Dec 9;15(12):9035-45.
25. Behbahani M, Ali AM, Muse R, Mohd NB. Anti-oxidant and anti-inflammatory activities of leaves of Barringtonia racemosa. Journal of Medicinal Plants Research. 2007 Dec 1;1(5):95-102.
2. Soeken KL, Miller SA, Ernst E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. Rheumatology. 2003 May 1;42(5):652-9.
3. Rathore B, Mahdi AA, Paul BN, Saxena PN, Das SK. Indian herbal medicines: Possible potent therapeutic agents for rheumatoid arthritis. Journal of clinical biochemistry and nutrition. 2007;41(1):12-7.
4. Yang CL, Or TC, Ho MH, Lau AS. Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis. Clinical Reviews in Allergy & Immunology. 2013 Jun;44:284-300.
5. Chandrasekar R, Chandrasekar S. Natural herbal treatment for rheumatoid arthritis-a review. International Journal of Pharmaceutical Sciences and Research. 2017 Feb 1;8(2):368.
6. Li TP, Zhang AH, Miao JH, Sun H, Yan GL, Wu FF, Wang XJ. Applications and potential mechanisms of herbal medicines for rheumatoid arthritis treatment: a systematic review. RSC advances. 2019;9(45):26381-92.
7. Lindler BN, Long KE, Taylor NA, Lei W. Use of herbal medications for treatment of osteoarthritis and rheumatoid arthritis. Medicines. 2020 Oct 28;7(11):67.
8. Kaur A, Nain P, Nain J. Herbal plants used in treatment of rheumatoid arthritis: a review. Int J Pharm Pharm Sci. 2012;4(4):44-57.
9. Delazar A, Sarker SD, Nahar L, Jalali SB, Modaresi M, Hamedeyazdan S, Babaei H, Javadzadeh Y, Asnaashari S, Moghadam SB. Rhizomes of Eremostachys laciniata: isolation and structure elucidation of chemical constituents and a clinical trial on inflammatory diseases. Advanced Pharmaceutical Bulletin. 2013 Dec;3(2):385.
10. Khan S, Nisar M, Rehman W, Khan R, Nasir F. Anti-inflammatory study on crude methanol extract and different fractions of Eremostachys laciniata. Pharmaceutical biology. 2010 Oct 1;48(10):1115-8.
11. Erdemoglu N, Turan NN, Cakõcõ I, Sener B, Aydõn A. Antioxidant activities of some Lamiaceae plant extracts. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2006 Jan;20(1):9-13.
12. Shoara R, Hashempur MH, Ashraf A, Salehi A, Dehshahri S, Habibagahi Z. Efficacy and safety of topical Matricaria chamomilla L.(chamomile) oil for knee osteoarthritis: a randomized controlled clinical trial. Complementary therapies in clinical practice. 2015 Aug 1;21(3):181-7.
13. Sumantran VN, Kulkarni A, Boddul S, Chinchwade T, Koppikar SJ, Harsulkar A, Patwardhan B, Chopra A, Wagh UV. Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis. Journal of Biosciences. 2007 Mar;32:299-307.
14. Ramakanth GS, Kumar CU, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. Journal of Ayurveda and integrative medicine. 2016 Jul 1;7(3):151-7.
15. Susmitha U, Kavitha R, Amareswarapu VS, Kiran Y, Mohammed G, Sriram N, Prasad PN. Effect of Pisonia Alba Root Extract On Cafeteria Diet-Induced Obesity In Rats. Journal of Pharmaceutical Negative Results. 2022 Dec. 1 [cited 2023 Feb. 15]; 3732-9.
16. Singh D, Aggarwal A, Maurya R, Naik S. Withania somnifera inhibits NF‐κB and AP‐1 transcription factors in human peripheral blood and synovial fluid mononuclear cells. Phytotherapy Research. 2007 Oct;21(10):905-13.
17. Ganesan K, Sehgal PK, Mandal AB, Sayeed S. Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Applied biochemistry and biotechnology. 2011 Oct;165:1075-91.
18. Sivaranjini A, Maya R, Senthilkumar PK, Narayana Rao A, Phaneendra Pavan D, Gnanasekaran A, Sriram N, Susmitha U. Antimicrobial Properties of Morinda Reticulata Gamble Extracts against Antibiotic-Resistant Pathogenic Bacteria and Toxin Producing Molds. Journal of Pharmaceutical Negative Results. 2023 Jan. 1 [cited 2023 Feb. 15];6633-9.
19. Khan, M.A., Ahmed, R.S., Chandra, N., Arora, V.K. and Ali, A., 2019. In vivo, extract from Withania somnifera root ameliorates arthritis via regulation of key immune mediators of inflammation in experimental model of arthritis. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents), 18(1), pp.55-70.
20. Paul BN, Saxena AK. Depletion of tumor necrosis factor-α in mice by Nyctanthes arbor-tristis. Journal of ethnopharmacology. 1997 Apr 1;56(2):153-8.
21. Agarwal RB, Rangari VD. Antiinflammatory and antiarthritic activities of lupeol and 19 alpha-H lupeol isolated from Strobilanthus callosus and Strobilanthus ixiocephala roots. Indian Journal of Pharmacology. 2003;35(6):384-7.
22. Kim MS, Yi JM, Kim SH, Hong SH, Kim HM. Madimadi, Korean folk medicine, blocks TNF-α, IL-1β, and IL-8 production by activated human immune cells. Cytokine. 2004 Feb 21;25(4):179-86.
23. Jaijesh P, Srinivasan KK, Bhagath Kumar P, Sreejith G, Ciraj AM. Anti arthritic property of the plant Rubia cordifolia lin. Pharmacologyonline. 2008;1:107-13.
24. Garrido-Suárez BB, Garrido G, Delgado R, Bosch F, Rabí MD. A Mangifera indica L. extract could be used to treat neuropathic pain and implication of mangiferin. Molecules. 2010 Dec 9;15(12):9035-45.
25. Behbahani M, Ali AM, Muse R, Mohd NB. Anti-oxidant and anti-inflammatory activities of leaves of Barringtonia racemosa. Journal of Medicinal Plants Research. 2007 Dec 1;1(5):95-102.
Published
07/07/2023
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[1]
A. J. Talukdar, R. K. Mani, R. Malli, S. Shree, and F. Md, “The role of medicinal plants in rheumatoid arthritis-an updated review”, Int J Indig Herb Drug, vol. 8, no. 3, pp. 16-20, Jul. 2023.
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