Premature ovarian insufficiency: an augmenting disorder in the growing female population

Gagana B  A; Priyanka D  G; Sunil Gowda H  P; Sagheer Ahmed Syed; Rupesh Kumar M; Surabhi H M

doi:10.46956/ijihd.v8i1.425

Gagana B A Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.
Priyanka D G Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.
Sunil Gowda H P Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.
Syed Sagheer Ahmed Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.
Rupesh Kumar M Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.
Surabhi H M Department of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B. G Nagara, Mandya Dist., Karnataka.

DOI https://doi.org/10.46956/ijihd.v8i1.425

Abstract

A primary ovarian abnormality such as absent menarche (primary amenorrhea) or early depletion of ovarian follicles/arrested folliculogenesis before the age of 40 is described as premature ovarian insufficiency (secondary amenorrhea). Itsprevalence is 1% and 0.1 % in women under 40 and 30 respectively. Common Symptoms include palpitations, excessive sweating, flushes, anxiety, depression, and fatigue. There could be a variety of causes, including chromosomal abnormalities, autoimmune diseases, infections, idiopathic diseases, iatrogenic diseases, and so on. Diagnosis is usually done based on the level of hormones like estradiol, Follicle Stimulating Harmone, and LuteinizingHarmone. Considering the complications of premature ovarian failure, it is necessary to educate the female population about this disorder. Hence, the Present review focuses on the etiology, symptoms, complications, diagnosis, and treatment of premature ovarian failure.

Keywords: ovarian abnormality

Downloads

Download data is not yet available.

References

1. Beck-Peccoz, P., Persani, L. Premature ovarian failure. Orphanet J Rare Dis 1, 9 (2006).
2. Jankowska K. Premature ovarian failure. Menopause Review/Przegląd Menopauzalny. 2017;16(2):51-56. doi:10.5114/pm.2017.68592.
3. Deepti Goswami, Gerard S. Conway, Premature ovarian failure, Human Reproduction Update, Volume 11, Issue 4, July/August 2005, Pages 391–410.
4. Ishizuka B (2021) Current Understanding of the Etiology, Symptomatology, and Treatment Options in Premature Ovarian Insufficiency (POI). Front. Endocrinol. 12:626924.
5. Maclaran K, Panay N. Current Concepts in Premature Ovarian Insufficiency. Women’s Health. 2015;11(2):169-182.
6. J Midlife Health. 2015 Oct-Dec; 6(4): 147–153.
7. Maclaran K, Panay N. Presentation and management of POI: findings from the West London POI database. In15th World Congress of Gynecological Endocrinology. Florence, Italy 2012 Mar (pp. 7-10).
8. Ulin, M., Cetin, E., Hobeika, E. et al. Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency. Reprod. Sci. 28, 1688–1696 (2021).
9. Gupta A, Tiwari P, Khare C. Premature ovarian insufficiency: a review. EMJ Reprod Health. 2019;10:19-00041.
10. van Kasteren YM, Schoemaker J. Premature ovarian failure: A systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. Hum Reprod Update. 1999;5(5):483-92.
11. Groff AA, Covington SN, Halverson LR, Fitzgerald OR, Vanderhoof V, Calis K, Nelson LM. Assessing the emotional needs of women with spontaneous premature ovarian failure. Fertility and sterility. 2005 Jun 1;83(6):1734-41.
12. Konda RK.G Venkata Nagaraju. Brief description of Clinical Case study formats: a basic review. Journal of Case Studies and Case Reports. 2022 Apr 30:24-6.
13. American Academy of Pediatrics. American College of Obstetricians and Gynecologists; Committee on Obstetric Practice. The Apgar score. Adv Neonatal Care. 2006;6:220-3.