Potential application of Euphorbia thymifolia linn. in diabetic neuropathy

Rakesh Kumar Jain Rakesh Kumar Jain; Vijeta Rajoriya Vijeta Rajoriya; Vaibhav Rajoriya Vaibhav Rajoriya; Akash Sharma Akash Sharma; Varsha Kashaw Varsha Kashaw

Rakesh Kumar Jain SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University Sagar, 470228 (MP), India
Vijeta Rajoriya Sagar Institute of Pharmaceutical Sciences, Sagar, 470228 (MP), India
Vaibhav Rajoriya Deptt. of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, 470001 (M.P), India
Akash Sharma Sagar Institute of Pharmaceutical Sciences, Sagar, 470228 (MP), India
Varsha Kashaw SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University Sagar, 470228 (MP), India

Abstract

Objective: The present study shows the anti-diabetic activity of ethanolic extract of Euphorbia thymifolia Linn leaves in streptozocin (STZ) induced diabetic Wistar rat. This drug is never used for the treatment of diabetic neuropathy therefore; we propose to test this plant in the diabetic neuropathic condition. Methods: The study was performed on Wistar rat by administration of STZ (65 mg/kg IP) and nicotinamide (110 mg/kg IP). Elevation in blood glucose level shows the induction of diabetes. Parameters like body weight, thermal pain sensitivity, muscle grip strength, blood and urine protein level and creatinine level were used to evaluate the effect of ethanolic extract of Euphorbia thymifolia in rat. Results: The ethanolic extract of Euphorbia thymifolia Linn. (red and green) leaves show synergistic effect in thermal pain sensitivity and muscle relaxant. The extract (red and green) showed no weight gain, decreased paw jumping response, increased muscle grip strength, decrease in blood glucose level, increase in blood protein, decrease in urinary protein and decrease serum creatinine level on 35th day of treatment as compared with negative control.. Conclusion: Euphorbia thymifolia Linn showed the maximum response in diabetic neuropathy at dose of 200 mg/kg.

Keywords: Euphorbia thymifolia, Anti-diabetic activity, Diabetic Neuropathy

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