Ethnopharmacological aspects of resveratrol (a French paradox) – A review
Abstract
The origin of the name resveratrol is reportedly derived from the Latin word ‘res’ meaning ‘which comes from’ the plant ‘veratrum’ and ‘ol’ indicating the presence of an alcohol moiety. Resveratrol is obtained from plants. The function of resveratrol in plants is thought to be protection since it is produced when the plant is under environmental stress, whether ultraviolet radiation, infection, or insect infestation. Resveratrol’s introduction into the dietary supplement market a few years back was based upon the consideration that intake of it and other polyphenol compounds from red wine may contribute to the ‚French paradox‛, the unexpectedly low rate of death from cardiovascular disease in the Mediterranean population, despite a diet that is relatively high in saturated fat. Since then, interest in resveratrol has increased due to research suggesting additional antioxidant, anti-inflammatory, anticancer, antiviral, and anti-aging effects; as well as possibly playing a role in weight loss and athletic performance. Resveratrol has emerged as a leading candidate for improving healthspan through potentially slowing the aging process and preventing chronic diseases. This review summarizes the ethnopharmacological aspects of resveratrol and provides suggested directions for future research in this realm.
Keywords:
Resveratrol, Polyphenols, Pharmacological actions, Red wine
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References
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5. Siemann EH, Creasy LL. Concentration of the phytoalexin resveratrol in wine. Am J Eno Vitic 1992; 43: 49-52.
6. Renaud S, Lorgeril DM. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339: 1523-1526.
7. Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275: 218-220.
8. Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 2004; 22: 169-188.
9. Wang Q, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002; 958: 439-447.
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11. Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191–196.
12. Valenzano DR, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short lived vertebrate. Curr Biol 2006; 16: 296-300.
13. Prasad K. Resveratrol wine and atherosclerosis. Into J Angiol 2012; 21: 7-18.
14. Gehm BD, et al. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Nat Acad Sci 1997; 94: 14138–14143.
15. Lagouge M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell 2006; 127: 1109–1122.
16. Buryanovskyy L, et al. Crystal structure of quinine reductase 2 in complex with resveratrol. Biochem 2004; 43: 11417-11426.
17. Seaver B, Smith JR. Inhibition of COX isoforms by nutraceuticals. J Herb Pharmacother 2004; 4: 11-8.
18. Pham-Marcou TA, Beloeil H, Sun X, Gentili M, et al. Antinociceptive effect of resveratrol in carrageenan evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment. Pain 2008; 140: 274-83.
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24. Schmatz R, Mazzanti CM, Spanevello R, et al. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol 2009; 610: 42-48.
25. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K. Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease. Atherosclerosis 2008; 196: 49-58.
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28. Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 2011; 667: 258-64.
29. Soner BC, Murat N, Demir O, Guven H, Esen A, Gidener S. Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction? Int J Impot Res 2010; 22: 227-233.
30. Wang Y, Lee KW, Chan FL, Chen S, Leung LK. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci 2006; 92: 71-77.
31. Van Poppel H, Tombal B. Chemoprevention of prostate cancer with nutrients and supplements. Cancer Manag Res 2011; 3: 91-100.
32. Tseng PC, Hou SM, Chen RJ, et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res. 2011; 26: 2552-2563.
33. Smoliga JM, Baur, JA, Hausenblas HA. Resveratrol and health-a comprehensive review of human clinical trials. Mol Nut Food Res 2011; 55: 1129-1141.
34. Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety pharmacokinetics and effect on the insulin-like growth factor axis. Cancer Res 2010; 70: 9003-9011.
35. Ghanim H, Sia CL, Korzeniewski K, et al. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab 2011; 96: 1409-1414.
36. Agarwal B, Campen MJ, Channell MMet al. Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium. Int J Cardiol 2013; 166: 246–248.
37. Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in Type 2 diabetes mellitus-systematic review and meta-analysis. Mol Nutr Food Res 2015; 59:147-159.
38. Elliott P, Walpole S, Morelli L, et al. Resveratrol /SRT-501. Drugs Future 2009; 34: 291-295.
39. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010; 91: 1590-1597.
40. Wong RH, Berry NM, Coates AM, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens 2013; 31: 1819-1827.
41. Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improvesflow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis 2011; 21: 851–856.
42. Turner RT, Evans GL, Zhang M, Maran A, Sibonga JD. Is resveratrol an estrogen agonist in growing rats? Endocrinology 1999; 140: 50–54.
43. Freyberger A, Hartmann E, Hildebrand H, Krotlinger F. Differential response of immature rat uterine tissue to
ethinylestradiol and the red wine constituent resveratrol. Arch Toxicol 2001; 74: 709-715.
44. Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol 2004; 53: 1003-1009.
45. Sinclair DA, Howitz KT. In Handbook of the biology of aging, Eds Masoro, EJ & Austad SN, Elsevier, Boston, 2006: 63–104.
2. Langcake P, Pryce RJ. Production of resveratrol by vitis vinifera and other members of vitaceae as a response to infection or injury. Physio Plant Path 1976; 9: 77–86.
3. Nonomura S, Kanagawa H, Makimoto A. Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-jo-kon (Polygonum cuspidatum Sieb. et Zucc.). Yakugaku Zasshi 1963; 83: 988-990.
4. Langcake P, Pryce RJ. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol Plant Pathol 1976; 9: 77-86.
5. Siemann EH, Creasy LL. Concentration of the phytoalexin resveratrol in wine. Am J Eno Vitic 1992; 43: 49-52.
6. Renaud S, Lorgeril DM. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339: 1523-1526.
7. Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275: 218-220.
8. Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 2004; 22: 169-188.
9. Wang Q, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002; 958: 439-447.
10. Sinha K, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci 2002; 71: 655–665.
11. Howitz KT, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191–196.
12. Valenzano DR, et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short lived vertebrate. Curr Biol 2006; 16: 296-300.
13. Prasad K. Resveratrol wine and atherosclerosis. Into J Angiol 2012; 21: 7-18.
14. Gehm BD, et al. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Nat Acad Sci 1997; 94: 14138–14143.
15. Lagouge M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha. Cell 2006; 127: 1109–1122.
16. Buryanovskyy L, et al. Crystal structure of quinine reductase 2 in complex with resveratrol. Biochem 2004; 43: 11417-11426.
17. Seaver B, Smith JR. Inhibition of COX isoforms by nutraceuticals. J Herb Pharmacother 2004; 4: 11-8.
18. Pham-Marcou TA, Beloeil H, Sun X, Gentili M, et al. Antinociceptive effect of resveratrol in carrageenan evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment. Pain 2008; 140: 274-83.
19. Faith SA, Sweet TJ, Bailey E, Booth T, Docherty JJ. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells. Antiv Res 2006; 72: 242-51.
20. Xu Y, Wang Z, You W, et al. Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol. 2010; 20: 405-13.
21. Juhasz B, Das DK, Kertesz A, Juhasz A, Gesztelyi R, Varga B. Reduction of blood cholesterol and ischemic injury in the hypercholesteromic rabbits with modified resveratrol, longevinex. Mol Cell Biochem. 2011; 348: 199-203.
22. Correia-da-Silva M, Sousa E, Duarte B, et al. Dual anticoagulant/antiplatelet persulfated small molecules. Eur J Med Chem 2011; 46: 2347-58.
23. Hua J, Guerin KI, Chen J, et al. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011; 52: 2809-2816.
24. Schmatz R, Mazzanti CM, Spanevello R, et al. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol 2009; 610: 42-48.
25. Cruz MN, Agewall S, Schenck-Gustafsson K, Kublickiene K. Acute dilatation to phytoestrogens and estrogen receptor subtypes expression in small arteries from women with coronary heart disease. Atherosclerosis 2008; 196: 49-58.
26. Böttner M, Christoffel J, Rimoldi G, Wuttke W. Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on the pituitary-thyroid-axis. Exp Clin Endocrinol Diab 2006; 114: 82-90.
27. Mukherjee S, Ray D, Lekli I, Bak I, Tosaki A, Das DK. Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action. Can J Physiol Pharmacol. 2010; 88:1017-1025.
28. Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 2011; 667: 258-64.
29. Soner BC, Murat N, Demir O, Guven H, Esen A, Gidener S. Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction? Int J Impot Res 2010; 22: 227-233.
30. Wang Y, Lee KW, Chan FL, Chen S, Leung LK. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci 2006; 92: 71-77.
31. Van Poppel H, Tombal B. Chemoprevention of prostate cancer with nutrients and supplements. Cancer Manag Res 2011; 3: 91-100.
32. Tseng PC, Hou SM, Chen RJ, et al. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis. J Bone Miner Res. 2011; 26: 2552-2563.
33. Smoliga JM, Baur, JA, Hausenblas HA. Resveratrol and health-a comprehensive review of human clinical trials. Mol Nut Food Res 2011; 55: 1129-1141.
34. Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety pharmacokinetics and effect on the insulin-like growth factor axis. Cancer Res 2010; 70: 9003-9011.
35. Ghanim H, Sia CL, Korzeniewski K, et al. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab 2011; 96: 1409-1414.
36. Agarwal B, Campen MJ, Channell MMet al. Resveratrol for primary prevention of atherosclerosis: Clinical trial evidence for improved gene expression in vascular endothelium. Int J Cardiol 2013; 166: 246–248.
37. Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in Type 2 diabetes mellitus-systematic review and meta-analysis. Mol Nutr Food Res 2015; 59:147-159.
38. Elliott P, Walpole S, Morelli L, et al. Resveratrol /SRT-501. Drugs Future 2009; 34: 291-295.
39. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010; 91: 1590-1597.
40. Wong RH, Berry NM, Coates AM, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens 2013; 31: 1819-1827.
41. Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improvesflow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis 2011; 21: 851–856.
42. Turner RT, Evans GL, Zhang M, Maran A, Sibonga JD. Is resveratrol an estrogen agonist in growing rats? Endocrinology 1999; 140: 50–54.
43. Freyberger A, Hartmann E, Hildebrand H, Krotlinger F. Differential response of immature rat uterine tissue to
ethinylestradiol and the red wine constituent resveratrol. Arch Toxicol 2001; 74: 709-715.
44. Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Mol Microbiol 2004; 53: 1003-1009.
45. Sinclair DA, Howitz KT. In Handbook of the biology of aging, Eds Masoro, EJ & Austad SN, Elsevier, Boston, 2006: 63–104.
Published
28/02/2017
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R. S. P. Rajesh Singh Pawar, D. I. Deepa Iyer, S. S. Sunny Sinha, and P. P. Pradeep Pateriya, “Ethnopharmacological aspects of resveratrol (a French paradox) – A review”, Int J Indig Herb Drug, pp. 14-19, Feb. 2017.
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