DEVELOPMENT AND EVALUATION OF METFORMIN LIPOSOME FORMULATIONS

Vijay  Kumar; Aparna  Joshi; KAPIL Kumar; Deepak  Teotia; Ikram; Deepti  Khairya

doi:10.46956/ijihd.v7i5.356

Vijay Kumar Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Aparna Joshi Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Kapil Kumar Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Deepak Teotia Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Ikram Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India
Deepti Khairya Department of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur- 244713, Uttarakhand, India

DOI https://doi.org/10.46956/ijihd.v7i5.356

Abstract

This inquiry focuses on liposomes as its subject matter. Liposomes are an excellent means of increasing the period of time during which an impact is active from hours to months. In the current investigation, liposomal formulations of metformin hydrochloride were created and analysed by the researchers. Because its plasma half-life is much shorter than that of other drugs (t1/2 = 1.5 h), the patient has to take the drug more often in order to keep its concentration in steady state plasma. In this study, liposomal formulations of metformin were tested for drug entrapment, surface characterisation, in-vitro drug release investigations, release kinetics, and their underlying processes. Study concludes that the development of liposomal solutions of metformin hydrochloride was a fruitful endeavour.

Keywords: Liposomes, metformin, in-vitro drug release

Downloads

Download data is not yet available.

References

1. Obanewa OA, Oyeniran OT. Development and estimation of anti-inflammatory activity of topical etoricoxib emulgel by carrageenan induced paw oedema method. Universal Journal of Pharmaceutical Research 2019; 4(3): 22-26.
2. Male U, Uppugalla S, Srinivasan P. Effect of reduced graphene oxide–silica composite in polyaniline: electrode material for high-performance supercapacitor. Journal of Solid State Electrochemistry. 2015 Nov;19(11):3381-8.
3. Dingwoke John Emeka Francis, Felix Sunday Yusuf. Development and evaluation of nanosponges loaded extended release tablets of lansoprazole. Universal Journal of Pharmaceutical Research 2019; 4(1): 24-28.
4. Uppugalla S, Male U, Srinivasan P. Design and synthesis of heteroatoms doped carbon/polyaniline hybrid material for high performance electrode in supercapacitor application. Electrochimica Acta. 2014 Nov 10;146:242-8.
5. Nweje-Anyalowu Paul C, Anyalogbu Ernest AA, White Alalibo Jim. Design and evaluation of chronotherapeutic pulsatile drug delivery system of Cilnidipine. Universal Journal of Pharmaceutical Research 2017; 2(5): 15-18.
6. Uppugalla S, Srinivasan P. High-performance supercapacitor coin cell: polyaniline and nitrogen, sulfur-doped activated carbon electrodes in aqueous electrolyte. Journal of Solid State Electrochemistry. 2019 Jan;23(1):295-306.
7. Peter OI, Ifeoma UC. Development and evaluation of Albendazole microcapsule for colonic drug delivery system. Universal Journal of Pharmaceutical Research 2017; 2(2): 4-7.
8. Singh, A., Gowtham, S., Chakrapani, L.N., Ashokkumar, S., Kumar, S.K., Prema, V., Bhavani, R.D., Mohan, T. and Sathyamoorthy, Y.K., 2018. Aegeline vs Statin in the treatment of Hypercholesterolemia: A comprehensive study in rat model of liver steatosis. Functional Foods in Health and Disease, 8(1), pp.1-16.
9. Kaur G, Paliwal S. Formulation and evaluation of etoricoxib microbeads for sustained drug delivery. Universal Journal of Pharmaceutical Research 2019; 4(1): 35-39.
10. New, R.R.C., Preparation of liposomes. In: New, R.R.C.(Ed.), Lipsomes: a practical approach, IRL Press, Oxford,1990, pp. 33104.
11. Sunday OS. Colon-targeted drug delivery systems: design, trends and approaches. Universal Journal of Pharmaceutical Research 2017; 2(4): 46-50.
12. Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.
13. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071.
14. Elsaied EH, Dawaba HM, Ibrahim EA, Afouna MI. Investigation of proniosomes gel as a promising carrier for transdermal delivery of Glimepiride. Universal Journal of Pharmaceutical Research 2016; 1(2): 1-10.
15. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
16. Ugochukwu AE, Nnedimkpa OJ, Rita NO. Preparation and characterization of Tolterodine tartrate proniosomes, Universal Journal of Pharmaceutical Research 2017; 2(2): 1-3.
17. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
18. Anwar W, Dawaba HM, Afouna MI, Samy AM.Screening study forformulation variables in preparation and characterization of candesartan cilexetil loaded nanostructured lipid carriers. Universal Journal of Pharmaceutical Research 2019; 4(6):8-19.
19. Vishvakrama, P., & Sharma, S. Liposomes: anoverview. Journal of Drug Delivery and Therapeutics, 2014; 47-55. https://doi.org/10.22270/jddt.v0i0.843
20. Chioma ED. Formulation and evaluation of etodolac niosomes by modified ether injection technique. Universal Journal of Pharmaceutical Research 2016; 1(1): 1-4.
21. Abhilasha, S., Narasimhan, C.L., Kumar, S.A., Kumar, S.N.K., Bhavani, R.D., Thangarajeswari, M., Prema, V. and Kalaiselvi, P., 2017. Ethanolic extract of aegle marmelos mediates its hypocholesterolemic effect by retarding circulatory oxidized ldl formation via 12/15 lipoxygenase pathway.
22. Mathur P, Mathur CK, Mathur K. Oral drug delivery of insulin in diabetes mellitus: an attractive alternate to overcome invasive route. Universal Journal of Pharmaceutical Research 2018; 3(6): 45-48.
23. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
24. Elsaied EH, Dawaba HM, Ibrahim ESA, Afouna MI. Effect of pegylated edge activator on Span 60 based nanovesicles: comparison between Myrj 52 and Myrj 59. Universal Journal of Pharmaceutical Research 2019;4(4):1-8.
25. Roh, J., Hill, J.A., Singh, A., Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
26. John DF, Yunus AA, Chigbo UJ, Paul US, Ikenna E. Tolnaftate loaded liposomes-design, and in-vitro evaluation. Universal Journal of Pharmaceutical Research 2016; 1(2): 29-31.
27. Ejiogu Deborah Chioma. Formulation and evaluation of etodolac niosomes by modified ether injection technique. Universal Journal of Pharmaceutical Research. 2016; 1(1): 1- 6.
28. Nwobodo NN, Adamude FA, Dingwoke EJ, Ubhenin A. Formulation and evaluation of elastic liposomes of decitabine prepared by rotary evaporation method. Universal Journal of Pharmaceutical Research 2019; 4(3): 1-5.