Synthesis and in-vitro evaluation of 3-[(benzylidine)-amino]-2-phenyl-3H-quinazoline-4-one derivatives as antioxidant agents

Nimisha Jain Nimisha Jain; Priyanka Tiwari Priyanka Tiwari; Supriya Sharma Supriya Sharma; P.K. Singour P.K. Singour

Nimisha Jain Department of Pharmaceutical Chemistry, VNS Group of Institutions, Faculty of Pharmacy, Neelbud, Bhopal, 462044, MP (India)
Priyanka Tiwari Department of Pharmaceutical Chemistry, VNS Group of Institutions, Faculty of Pharmacy, Neelbud, Bhopal, 462044, MP (India)
Supriya Sharma Department of Pharmaceutical Chemistry, VNS Group of Institutions, Faculty of Pharmacy, Neelbud, Bhopal, 462044, MP (India)
P.K. Singour Department of Pharmaceutical Chemistry, VNS Group of Institutions, Faculty of Pharmacy, Neelbud, Bhopal, 462044, MP (India)

Abstract

Objective: Synthesis and in-vitro evaluation of 3-[(benzylidine)-amino]-2-phenyl-3H-quinazoline-4-one derivatives as antioxidant agents. Methods: Novel 3-[(benzylidine)-amino]-2-phenyl-3H-quinazoline-4-one derivatives were synthesized and evaluated of their scavenging activity which was used for the determination of antioxidant action against free radicals like DPPH (1,1–diphenyl-2-picrylhydrazyl). The structures of the synthesized compounds were assigned on the basis of spectroscopic analysis UV (ultraviolet), FT- IR (fourier transform infrared spectroscopy) and NMR (nuclear magnetic resonance spectroscopy) spectral data. Results: Compounds 3-[(4-hydroxy-benzylidine)-amino]-2-phenyl-3H-quinazoline-4-one (PT-2) and 3-[(3, 4 dimethoxy-benzylidine) - amino]-2-phenyl-3H-quinazoline-4-one (PT-3) showed good scavenging activity. Better activity of PT-2 compound may be due to the presence of hydroxyl group at the para position. Conclusion: In the present study, four compounds have been synthesized. The synthesized compounds showed a significant antioxidant activity.

Keywords: Quinazoline, Scavenging activity, Antioxidants, Spectroscopic analysis

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