The Traditional and Pharmacological Properties of Solanum nigrum: a Review

  • Rupesh Kumar Mani Department of Pharmacology, Sri Adichunchanagiri College Of Pharmacy
  • Paramashree J B Department of Pharmacology, Sri Adichunchanagiri College Of Pharmacy
  • Bharathi D R Department of Pharmacology, Sri Adichunchanagiri College Of Pharmacy
  • Syed Sagheer Ahmed Department of Pharmacology, Sri Adichunchanagiri College Of Pharmacy

Abstract

Solanum nigrum has a place in the Solanaceae family with a common name of garden nightshade. It is composed of a variety of glycoalkaloids, glycoproteins, polysaccharides and polyphenolic mixtures such as gallic acid, catechin, protocatechuic acid, and caffeic acid, epicatechin, and rutin. Solanum nigrum have hepatoprotective, antitumor, immunomodulatory, anti-ulcer, calming, hostile to convulsant, cardio defensive, antibacterial, antidiabetic and pain-relieving impacts. Traditional medicine in India and other parts of the globe has used Solanum nigrum to treat liver disorders, constant skin sickness, fiery circumstances, menstrual cramps, fevers, diarrhoea, eye infections, dizziness and other diseases.

Keywords: Solanum nigrum, hepatoprotective, immunomodulatory

Downloads

Download data is not yet available.

References

1] Saleem TM, Chetty C, Ramkanth S, Alagusundaram M, Gnanaprakash K, Rajan VT, Angalaparameswari S. Solanum nigrum Linn.-A review. Pharmacognosy reviews. 2009 Jul 1;3(6):342.
2] Atanu FO, Ebiloma UG, Ajayi EI. A review of the pharmacological aspects of Solanum nigrum Linn. Biotechnology and Molecular Biology Reviews. 2011 Jan 31;6(1):1-8.
3] Saleem TM, Chetty C, Ramkanth S, Alagusundaram M, Gnanaprakash K, Rajan VT, Angalaparameswari S. Solanum nigrum Linn.-A review. Pharmacognosy reviews. 2009 Jul 1;3(6):342.
4] Cooper MR, Johnson AW (1984). Poisonous Plants in Britain and other effects on Animals and Man. Ministry of Agriculture, Fisheries Food, 161: 219-220.
5] M. Rajathi D. Modilal1, R. Anandan, R.Sindhuand M.N. Logeshwari. screening of solanum nigrum for its phytochemical and antimicrobial activity against respiratory tract pathogens: International Journal of Pure and Applied Zoology, 2015; 3(3): 1.
6] S.E.1. Potawale, S.D.1. Sinha, K.K.1. Shroff, H.J.1. Dhalawat, S.S.2. Boraste, S.P.3. Gandhi, A.D.4. Tondare. Solanum Nigrum Linn: A Phytopharmacological Review: Pharmacologyonline, 2008; 3: 2.
7] Turner NJ, Szczawinski AF. Common Poisonous Plants and Mushrooms of North America.1974:128.
8] Muto M, Mulabagal V, Huang HC, Takahashi H, Tsay HS. Huang JW. Japan toxicity of black nightshade (Solanum nigrum) extracts on Alternaria brassicicola, causal agent of black leaf spot of Chinese cabbage (Brassica pekinensis) .Department of International Agricultural Development, Tokyo University of Agriculture, Sakuragaoka, Setagaya-ku, Tokyo.
9] Ravi V, Saleem TSM, Maiti PP, Gauthaman K, Ramamurthy J. Phytochemical and pharmacological evaluation of Solanum nigrum Linn. African Journal of Pharmacy and Pharmacology. 3(9): 2009; 454-457.
10] Rajani Chauhan, Km. Ruby1, Aastha Shori, Jaya Dwivedi1. solanum nigrum with dynamic therapeutic role: a review: Int. J. Pharm. Sci. Rev. Res, 2012; 15(1): 4.
11]Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants, PID, New Delhi, 1956, 229.
12] Hussain AOD, Virmani, Pople SP. Dictionary of Indian medicinal plants, Central Institute of Medicinal and Aromatic Plants, Lucknow, 1992, 35.
13] Kirtikar KR, Basu BD. Indian medicinal plants, 2nd ed, Lalit Mohan Basu, Allahabad, 1935, III.
14] Nadkarni KM. Indian Materia Medica, 3rd ed, Popular Prakashan, Bombay, 1976; I:1156.
15]The useful plants of India, (Publication & Information Directorate CSIR, New Delhi, 1992, 581.
16] Kuppuswamy R, Govindaraju A, Velusamy G, Balasubramanian R, Balasundarm J and Sellamuthu M. Effect of Dried Fruits of Solanum nigrum Linn, against CCl4- induced Hepatic Damage in Rats. Biol Pharm BullI. 2003; 26(11):1618-1619.
17] Patels S, Gheewala N, Suthar A,, Shah A. 0In-vitro cytotoxicity activity of solanum nigrum extracts against Hela cell lines and Vero cell lines. International journal of pharmacy and pharmaceutical sciences. 1(1): 2009;38-46.
18] Jian L, Qing-Wang L, Da-Wei G, Zeng-Sheng H, Wen-Zong L (2009). Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum Linne. Phytother. Res., 23(11): 1524-1530.
19] M. Jainu, CSS. Devi. Antioxidant effect of methanolic extracts of Solanum nigrum berries on aspirin induced gastric mucosal injury: Indian Journal of Clinical Biochemistry, 2004; 19(1): 8.
20] Bhatia N, Maiti PP, Kumar A, Tuli A, Ara T, Khan MU. Evaluation of cardio protective Activity of Methanolic Extract Of Solanum Nigrum Linn. in Rats. International Journal of Drug Development & Research. 3(3):2011; 139- 147.
21] Arunachalam G, Subramanian N, Pazhani GP, Karunanithi M, Ravichandran V. Evaluation of anti-inflammatory activity of methanolic extract of Solanum nigrum (Solanaceae).– Iranian Journal of Pharmaceutical Sciences Summer 5(3): 2009; 151-156.
22] Rawani A, Ghosh A Chandra G.nMosquito larvicidal activities of Solanum nigrum L. leaf extract against Culex quinquefasciatus. Parasitol Res. 107: 2010;1235–1240.
23] Chinthana, T. Ananthi. Protective effect of Solanum nigrum and Solanum trilobatum aqueous leaf extract on Lead induced neurotoxicity in Albino mice: Journal of Chemical and Pharmaceutical Research, 2012; 4(1): 7.
24] Akubugwo I. E, Obasi N.A, Chinyere G.C and Ugbogu A. Mineral and phytochemical contents in leaves of Amaranthus hybridus L and Solanum nigrum L. subjected to different processing methods. African Journal of Biochemistry Research. 2 (2): 2008; 040-044.
25] Ali NS, Singh K, Khan MI, Rani S. Protective effect of ethanolic extracts of Solanum nigrum on the blood sugar of albino rats. IJPSR. 1(9): 2010; 97-99.
26] Javed T, Usman AA, Sana R, Sidra R, Sheikh R. Invitro antiviral activity of Solanum nigrum against Hepatitis C Virus. Virology Journal. 2011; 8:26.
27] Hebbar SS, Harsha VH, Shripathi V et al . Ethnomedicine of Dharwad district in Karnatak, Indiaplants used in orl health care. . J Ethnopharmacol. 2004; 94: 261-266.
28]Ravi V, Saleem TSM, Patel SS, Raamamurthy J, Gauthaman K. Anti-inflammatory effect of methanolic extract of Solanum nigrum L berries. International Journal of Applied Research in Natural Products, 2009; 2(2):33-36.
29]Adebooye OC, Ram V, Vasudeva S (2008). Peroxidase activity, chlorophylls and antioxidant profile of two leaf vegetables (Solanum nigrum L. and Amaranthus cruentus L.) under six pretreatment methods before cooking. Int. J. Food Sci. Technol., 43(1): 173-178.
30]Heo KS, Lee S, Lim KT (2004). Cytotoxic effect of glycoprotein isolated from Solanum nigrum L. through the inhibition of hydroxyl radicalinduced DNA-binding activities of NF-kappa B in HT-29 cells. Environ. Toxicol. Pharmacol., 17(1): 45-54.
31]Kumar VP, Shashidhara S, Kumar MM, Sridhara BY (2001). Cytoprotective role of Solanum nigrum against gentamicin-induced kidney cell (Vero cells) damage in vitro. Fitoterapia. 72(5): 481-486.
32] Anti-seizure activity Km. Ruby et al., 2012 has performed on the aqueous extract of the leaves of Solanum nigrum was evaluated for anti-seizure activity in chicks, mice and rats by intraperitoneal administration of the extract. The anti-seizure property of the extract was potentiated by amphetamine.
33] FN. Razali, SK. Sinniah, H. Hussin, NZ. Abidin, AS. Shuib. Int. J. Biol. Macromolec, 2016; 92: 5.
34] Muto M, Mulabagal V, Huang HC, Takahashi H, Tsay HS, Huang JW. Toxicity of black nightshade (Solanum nigrum) extracts on (Alternaria brassicicola, causal agent of black leaf spot of Chinese cabbage (Brassica pekinensis). J. Phytopathol. 2006; 154 (1):45-50.
35] Amer HA, Manal MAR. Molluscicidal and cercaricidal efficacy of Acanthus mollis and its binary and tertiary combinations with Solanum nigrum and Iris pseudacorus against Biomphalaria alexandrina. J. Egyptian Soc. Parasitol. 2005; 34(3):1041-1050.
36] Raghavendra K, Singh SP, Subbarao SK, Dash AP. Laboratory studies on mosquito larvicidal efficacy of aqueous and hexane extracts of dried fruit of Solanum nigrum Linn. Indian J. Med. Res. 2009; 130(1):74-76.
37] Chinthana, T. Ananthi. Protective effect of Solanum nigrum and Solanum trilobatum aqueous leaf extract on Lead induced neurotoxicity in Albino mice: Journal of Chemical and Pharmaceutical Research, 2012; 4(1): 7.
38] Lee SJ, Ko JH, Lim K, Lim KT (2005). 150 kDa glycoprotein isolated from Solanum nigrum Linne enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse. Pharmacol. Res., 51(5): 399-408.
39] Villaseñor IM, Lamadrid MRA. (2006). Comparative anti-hyperglycemic potentials of medicinal plants . J. Ethnopharmacol., 104(1,2,8): 129- 131.
40] Lee S-J, Lim K-T (2006). 150 kDa glycoprotein isolated from Solanum nigrum Linne stimulates caspase-3 activation and reduces inducible nitric oxide production in HCT-116 cells. Toxicol. in Vitro, 20(7): 1088- 1097.
41] SS. El-Hawary, R. Mohammed, SF. AbouZid, W. Bakeer, R. Ebel, AM. Sayed, et al.J Appl Microbiol, 2016; 5.
42] Elias A, Ravichandran S, Karthika T, Maharajan T, Satyamala P and Lingeshwari D. Pharmacognostical, Phytochemical and Anthelmintic Activity on Leaves of Solanum nigrum Linn. Asian J Res Biol Pharm Sci.2013; 1(1):1-8.
43] Akubugwo IE, Obasi AN and Ginika SC. Nutritional Potential of the Leaves and Seeds of Bla ck NightshadeSolanum nigrumL.
44] Prakash S and Jain AK. Antifungal Activity and Preliminary Phytochemical Studies of Leaf Extract of Solanum nigrum Linn. Int J Pharm PharmSci. 2011; 3(4):352-355.
Published
30/04/2022
Statistics
1425 Views | 692 Downloads
Citatons
How to Cite
[1]
R. K. Mani, P. J B, B. D R, and S. S. Ahmed, “ The Traditional and Pharmacological Properties of Solanum nigrum: a Review”, Int J Indig Herb Drug, vol. 7, no. 2, pp. 49-55, Apr. 2022.
Section
Review Articles