Evaluation of anthelmintic potential of ethanolic extract of Murraya koenigii leaves

Ankit Raghuvanshi* Ankit Raghuvanshi*; Narendra Vyas Narendra Vyas; Sapna Malviya Sapna Malviya; Anil Kharia Anil Kharia

Ankit Raghuvanshi Modern Institute of Pharmaceutical Sciences, Indore-453111 (India)
Narendra Vyas Modern Institute of Pharmaceutical Sciences, Indore-453111 (India)
Sapna Malviya Modern Institute of Pharmaceutical Sciences, Indore-453111 (India)
Anil Kharia Modern Institute of Pharmaceutical Sciences, Indore-453111 (India)

Abstract

Objective: The ethanolic extract of leaves of Murraya koenigii was investigated for anthelmintic activity using earthworms Pheretima posthuma. Methods: Various concentrations of plant extract were tested in the bioassay. Albendazole (20 mg/ml) was used as reference standard drug whereas distilled water as control. Determination of paralysis time and death time of the worms were recorded. Results: Extract exhibited significant anthelmintic activity at highest concentration of 500 mg/ml. The results of the study shows that ethanolic extract of leaves of M. koenigii showed significant anthelmintic activity at a dose of 500 mg/ml when compared to standard drug albendazole at 20mg/ml concentration. Conclusion: Ethanolic extract possesses vermicidal activity and found to be effective as an anthelmintic.

Keywords: Anthelmintic, Murraya koenigii, Pheretima posthuma, Ethanolic extract

Downloads

Download data is not yet available.

References

1.Tandon V, Yadav AK, Roy B, Das B. Phytochemicals as cure of worm infections in traditional medicine system. Emerg Trend Zool 2011; 1: 351-378.
2. Nandhini A, Sumathi C. Review: An overview of herbals used in helminthiasis. World J Pharm Res 2014; 3: 350-362.
3. Arulselvan P, Senthil KGP, Sathish KD, Subramanian S. Antidiabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats. Pharmazie 2006; 61: 874-877.
4. Bonde SD, Nemade LS, Patel MR, Patel AA. Murraya koenigii (curry leaf): Ethnobotany, phytochemistry and pharmacology-A review. Int J Pharm Phytopharm Res 2007; 4: 45-54
5. Chowdhury JU, Bhuiyan Md. NI, Yusuf Md. Chemical composition of the leaf essential oils of Murraya koenigii
(L.) Spreng and Murraya paniculata (L.) Jack. Bangladesh J Pharmacol 2008; 3: 59-63.
6. Ajay S, Rahul S, Sumit G, Paras M, Mishra A,, Gaurav A. Comprehensive review: Murraya koenigii Linn. Asian J Pharm Life Sci 2011; 1: 417-425.
7. Agrawal VK. Anthelmintic activity of the seeds of Abrus precatorius Linn. JRIM 1975; 10:138-140.
8. Nethravathi HR, Prashith KTR, Vinayaka KS, Thippeswamy NB, Sudharshan SJ, Praveen KSV. Studies on antioxidant and anthelmintic activity of Gnidia glauca (Fresen) Gilg. Asian J Bio Sci 2010; 5: 6-9.
9. Adamu M, Naidoo V, Eloff JN. Efficacy and toxicity of thirteen plant leaf acetone extracts used in ethnoveterinary medicine in South Africa on egg hatching and larval development of H. contortus. BMC Vet Res 2013; 9:38.
10.Ahmed M, Lain MD, Nsahlai IV. In vitro anthelmintic activity of crude extracts of selected medicinal plants
against Haemonchus contortus from sheep. J Helminthol 2013; 87: 1749-179.