Comparative evaluation and anthelmintic potential of roots and leaves extracts of Lantana camara linn

Abstract

Objective: Anthelmintic activity of ethanolic extract of Lantana camara Linn roots and leaves in comparison with albendazole was evaluated through in vitro studies by the worm motility inhibition assay. Methods: In the present investigation, we have made a sincere attempt to evaluate the anthelmintic property of ethanolic extract of L. camara using Pheretima posthuma as an experimental helminthes model. Albendazole was used as the standard reference. Ethanolic extract of leaves and roots were tested at concentration of 250 mg/ml and 500 mg/ml respectively to determine their effect as the time taken to paralysis and time to induce death in the worms. Results: The results of the study show that significant anthelmintic effects (p < 0.001) were observed on leaves extract (500 mg/ml) of L. camara when compared with albendazole at 20 mg/ml concentration. Roots extract also showed anthelmintic activity but having lesser potential as compared to leaves extract of L. camara at 500 mg/ml concentration. Conclusion: This investigation revealed that leaves extract was more effective in its anthelmintic action against Pheretima posthuma when compared to roots extract. Leaves of L. camara Linn can be potential sources for novel anthelmintics.