Chemical and pharmacological investigations of red algae Hypnea musciformis

Rita Mourya Rita Mourya; S. S. Kumar S. S. Kumar

Rita Mourya Department of Pharmaceutical Chemistry, VNS Group of Institutions, Faculty of Pharmacy, Neelbud, Bhopal, 462044, MP (India)
S. S. Kumar Department of Pharmaceutical Chemistry, ITS Paramedical College (Pharmacy), Muradnagar, Ghaziabad, 201206, UP (India)

Abstract

Objective: Hypnea musciformis belongs to the family Hypneace, are often in clumps or masses 10-20 cm high of loosely intertwined cylindrical axes and branches. H. musciformis is easily distinguished by the presence of flattened, broad hooks at the tips of the branches. The study was designed to investigate the phytochemical potential and biological activity of H. musciformis. Methods: H. musciformis was successively extracted with petroleum ether, chloroform and ethyl acetate by maceration and was subjected to the phytochemical test. The fractions of ethyl acetate were analyzed by ultraviolet (UV) spectroscopy and infrared (IR) spectral methods. The petroleum ether extract, chloroform extract, ethyl acetate extract and ethyl acetate fractions were subjected to antibacterial and antifungal activity. Results: The antiviral activity and cytotoxicity of the extracts were tested in human embryonic lung (HEL) cells (herpes simplex virus-1, herpes simplex virus-2, vaccinia virus, vesicular stomatitis virus and herpes simplex virus-1 TK- KOS ACVr), human epithelial (HeLa) cells (vesicular stomatitis virus and coxsackie virus B4) and Vero cells (parainfluenza-3 virus, reovirus-1, sindbis virus coxsackie virus B4 and punta toro virus). Among the extracts and fractions, fractions of ethyl acetate exhibited remarkable results. This potentiality demonstrates that it could be used to treat bacterial and fungal infections. Conclusion: The results of this study had brought to light the effective utilization, chemical constituents and antibacterial, antifungal and antiviral activity of H. musciformis for further references for researchers.

Keywords: Hypnea musciformis, Seaweed, Red algae, Antibacterial activity, Antifungal activity, Antiviral activity

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