Formulation development and evaluation of Luliconazole Topical Emulgel
Abstract
The purpose of the present study was to develop and optimize the emulgel system for Luliconazole using different types of gelling agents: HPMCK15M, Carbopol 940, and Xanthan Gum. The prepared emulgels were evaluated in terms of appearance, pH, spreadability, viscosity, drug content, and in-vitro drug release. In-vitro release study demonstrated diffusion-controlled release of Luliconazole from formulation up to 12 hours. The drug release profile exhibited zero-order kinetics. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and higher drug release. In the case of all evaluation parameters, carbopol based formulation showed better properties so, as a general conclusion, it was suggested that the Luliconazole emulgel formulation prepared with carbopol (F6) was the formula of choice.
Keywords:
Luliconazole, Carbopol 940, Xanthan Gum, HPMC K15M
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References
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Mohamed MI. Topical emulsion- gel composition comprising Diclofenac sodium. AAPS Journal, 6(3), 2004.
Mohamed MI. Optimization of chlorphenesin emulgel formulation. AAPS Journal, 6(26), 2004.
Rieger MM, Lachman L, Lieberman HA. Editors. The theory and the practice of industrial pharmacy 3rd ed. Philadelphia; 1986.
Shahin M, Abdel HS, Hammad M, Mortada N. Drug development and industrial pharmacy,37(5):559-568, 2011. 6. British Pharmacopoeia. Appendix ID: A 143(4), 2008.
Andressa da S. Bitencourt; Sendy S. Oliveira; Andreas S. L. Mendez; Cássia V. Garcia. UV Spectrophotometric method for determination of posaconazole: comparison to HPLC. Rev Ciênc Farm Básica Apl., 2015;36(4):491-495.
Potu A, Pasunooti S, Veerareddy P, Burra S. Formulation & Evaluation of Fenoprofen calcium compressed coated tablets for Colon Speeific Drug Delvery. Asian Journal Pharmaceuticals clinical Research 2011; 4:88-95.
Karrout Y, Neut C, Wils D, Siepmann F, Deremaux L, Siepmann J. Novel PolymereFilm Coating for Colon Targeting Drug Release From Coated Pellets. European Journal of Pharmaceutical Sciences 2009; 37:427-433.
Ugurlu T, Turkoglu M, Gurer US, Akarsu BG. Colonic Delivery of Compression Coated Nisin tablets using Pectin/HPMC Polymer mixture. European Journal of Pharmaceutics And Biopharmaceutics 2007; 67:202-210.
Lakshmi KR, Muzib YI, Voleti VK. Design and Evaluation of colon specific drug delivery of Naproxen sodium using Guar gum and Crosslinced Guar Gum. International Journal of Pharmacy and pharmaceutical sciences. 2012; 4:284-288
Kirankumar GB, Naresh YS, Mohammed GA, Abdul NK. Design and Evaluation of a new capsule type dosage form for colon Targeted delivery of Etoricoxib. International Journal of Pharma Sciences 2013; 3: 147-151.
Verma S, Singh SK, Mishra DN, Gupta A, sharma R. formulation and evaluation of microbially triggered tablet of valdecoxib International Journal of Drug delivery Technology 2009;1: 6-11.
Ramasany T, Khandasamy US, Shanmugan S, Ruttala HA. Formulation and Evaluation of chondroitin sulphate tablets of Aceclofenac for colon Targeted Drug delivery. International Journal of Pharmaceutical Research 2012; 11: 465-479.
GB K, Annangi V, Ahamed M, Kumar G. Preparation and evaluation of kollidon SR matrix Tablets of Tinidazole for colon specific drug delivery . International Journal of science Invents today 2013; 2:97-106.
Krishnaiah YSR, Satyanarayana V, Kumar BD, Karthikeyan RS. In-vitro drug release studies on guar gum-based colon targeted oral drug delivery system of 5-fluorouracil European Journal of pharmaceutical of 2012; 16: 185-192.
Shailaja D, Kumar MS, Gnana Chaitanya NK. Formulation & Evaluation of Colon Specific Compression coated tablets of Etodolac International Journal of Pharma World Research 2012; 3:1-16.
Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate release ofsolid drugs dispersed in solid matrices. J. Pharm Sci. 1963; 52(12): 1145-9.
Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm.1983; 15(1): 25–35.
Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian J Res Pharm Sci. 2017 Jun 28;7:97-104.
V Jhansipriya Marabathuni, M. Bhavani, M. Lavanya, K. Padmaja, N. Madhavi, P. Babu, Ch. M. M. Prasada Rao. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian J. Pharm. Tech. 2017; 7 (3): 137-143.
Published
15/06/2021
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[1]
N. sai divya K, T Malyadri, and Ch.saibabu, “Formulation development and evaluation of Luliconazole Topical Emulgel”, Int J Indig Herb Drug, pp. 79-87, Jun. 2021.
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