A REVIEW ON HERBAL EXCIPIENTS
Abstract
The Herbal or natural excipients have great merit over their synthetic analogs as these are non-toxic, low-cost, and freely obtainable. The performance of the excipients partly determines the quality of the medicines. The plant acquired gums, mucilage from the natural origin for example carrageenan, thaumatin, lard, storax, agar, gum acacia, tragacanth, and excipients. They can also be easily altered to meet the specific needs, thereby being a potent many more to name comply with many requirements of the pharmaceutical and economic vehicle for transporting active pharmaceutical ingredients in the formulation. Thus present study aims to throw light on the probable of natural excipients which can be present to be used as a diluent, binder, disintegrant as well as lubricant in different types of formulations as they are biocompatible and capable of giving additional nutrition to the developed dosage form. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery systems.
Keywords:
Herbal excipients, Natural pharmaceutical aids, Natural polymers, Herbal binders
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References
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Pharmainfo. 2008; 6(3):1-18.
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31. Tonnesen HH. Karlssen J; Alginate in drug delivery systems Drug Develop Ind Pharm., 2002; 28:621-30.
2. Kumar T, Gupta SK, Prajapati MK, Tripathi DK, SharmaV, Jain P. Natural Excipients: A Review. AJPLS 2012; 2 (1):97-108.
3. Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K; Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem. Pharm Bull., 1996; 44: 2121–2127.
4. Wade A, Weller PJ; Handbook of Pharmaceutical Excipients.p.426-8. 11th ed. The Pharmaceutical Press: London. 1994.
5. Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K; Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem. Pharm Bull., 1996; 44: 2121–2127.
6. John GL, Declan MD, James EK; The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion. Eur. J. Pharm. Biopharm., 2006; 64:75-81.
7. Jain NK, Dixit VK; Studies on gums and their derivatives as binding agent. Indian J. Pharm. Sci., 1988; 50:113-114.
8. Owen SC, Raymond CR, Paul JS, Paul JW; Handbook of Pharmaceutical Excipients, the Pharmaceutical Press, and the American Pharmaceutical Association. 2003; 654-656.
9. Oluwatoyin O; Assessment of Albizia zygia gum as a binding agent in tablet formulations. Acta. Pharm., 2005; 55:263–276.
10. Jani GK, Shah DP, Jain VC; Evaluating mucilage from Aloe barbadensis Miller as a pharmaceutical excipient for sustained release matrix tablets. Pharm. Tech., 2007; 31: 90-98.
11. Patel MM, Chauhan GM, Patel LD; Mucilage of Lepidium sativum Linn (Asario) and Ocimum canum Sims. (Bavchi) as emulgents. Indian J. Hosp. Pharm., 1987; 24:200-202.
12. Pawar H, mello PM; Isolation of seed gum from Cassia tora and preliminary studies of its applications as a binder for tablets.
13. Indian Drugs, 2004; 41:465-468.
14. Shefter E, Raymond CR, Paul JS, Paul JW; Handbook of Pharmaceutical Excipients, the Pharmaceutical Press and the American Pharmaceutical Association 2003; 1-2.
15. Odeku OA, Itiola OA; Evaluation of the effects of khaya gum on the mechanical and release properties of paracetamol tablets. Drug Dev. Ind. Pharm., 2003; 29:311-320. Kulkarni GT, Gowthamrajan K, Rao GB; Evaluation of binding properties of selected natural mucilages. J. Sci. & Ind. Res., 2002; 61:529-532.
16. Antony PJ, Sanghavi NM; A new disintegrant for pharmaceutical dosage forms. Drug Dev. Ind. Pharm., 1997; 23:413-415.
17. Girish K, Dhiren JP, Shah VD, Prajapati VC; Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J. Pharm. Sci., 2009; 4(5): 309-332.
18. Girish K, Dhiren JP, Shah VD, Prajapati VC; Gums and mucilages: versatile excipients for pharmaceutical formulations Asian J. Pharm. Sci., 2009; 4( 5): 309-332.
19. Shirwaikar A, Prabu SL, Kumar GA; Herbal excipients in novel drug delivery systems, Indian J. Pharm. Sci., 2008; 70 : 415-42.
20. Tavakoli N, Ghasemi N, Taimouri R, Hamishehkar H; Evaluation of okra gum as a binder in tablet dosage forms. Iranian J Pharm Res., 2004; 2:47.
21. Jani GK, Shah DP; Assessing Hibiscus rosasinensis Linn as an Excipient in SustainedRelease Tablets.
22. Drug Develop Ind Pharm., 2008; 34 (8): 807 – 16.
23. Gleditsia triacanthos L. (online). 2009 (cited 2009 Nov 15. 25. Caesalpinia spinosa (online).2009 (cited 2009 Oct 22).
24. Aspinall GO, Bhattacharjee AK; Plant gums of the genus Khaya. Part IV. J Chem. Soc., 1970; 365–69.
25. Vazquez B, Avila G, Segura D, Escalante B; Anti-inflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol, 1996; 55:69-75.
26. Dav V, McCarthy SP; Review of Konjac Glucomannan. Journal of Environmental Polymer Degradation. 1997; 5(4):237.
27. Satpathy TK; Chitosan Used In Pharmaceutical Formulations: A Review.
Pharmainfo. 2008; 6(3):1-18.
28. Odeku OA, Fell JT; In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon. J Pharm Pharmacology., 2005; 57(2):163-68.
29. Barton P, Parslow N; Malignant, Krasner DL, Rodeheaver GT, Sibbald RG; Chronic Wound Care, A Clinical Source Book for Healthcare Professionals, Third Edition. Wayne, PA: HMP Communications. 2001; 699-710.
30. Madziva H, Kailasapathy K, Phillips M; Alginate-pectin microcapsules as a potential for folic acid delivery in foods. J Microencap, 2005; 22:343–51.
31. Tonnesen HH. Karlssen J; Alginate in drug delivery systems Drug Develop Ind Pharm., 2002; 28:621-30.
Published
15/02/2021
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How to Cite
[1]
Arpita singh, Nidhi Gupta, and Amresh Gupta, “A REVIEW ON HERBAL EXCIPIENTS”, Int J Indig Herb Drug, pp. 05-08, Feb. 2021.
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Review Articles
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