NEUROPROTECTIVE EFFECT OF FENCHONE ON CHRONIC UNPREDICTABLE MILD STRESS (CUMS) INDUCED NEUROINFLAMMATION

V. Siva Ganesh V. Siva Ganesh; K. Somasekhar Reddy K. Somasekhar Reddy; J.Balaraju J.Balaraju

V. Siva Ganesh Department of pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu, AP, India
K. Somasekhar Reddy Department of pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu, AP, India
J.Balaraju Department of pharmacology, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu, AP, India

Abstract

Background: Neuroinflammation has been suspected in the pathogenesis or the progression of the variety of acute and chronic neurological and neurodegenerative disorders including dementia. Aim: The current work is to study the action of fenchone on CUMS induced behavioral changes, oxidative stress and neuronal damage in rats. Methods: Adult male Wistar albino rats were grouped into five six in each. Group I treated with normal saline (0.9% NaCl i.p.), group II treated with normal saline + CUMS, group III treated with Aspirin (200 mg/kg) + CUMS, Group IV treated with fenchone (200 mg/kg) + CUMS (100 μg/kg) and Group V treated with fenchone (400 mg/kg) + CUMS for 27 days followed by single challenged of CUMS to all the groups except control rats. On 28th day onwards, various behavioral assessment such as locomotor activity, cognitive and memory assessment were carried out. Rats were sacrificed, and their brains were extracted and estimated antioxidant levels (SOD, CAT, GSH and TBARS). Results: CUMS treated rats significantly (P<0.001) decreased the body weight, locomotor activity, latency period in passive avoidance test and anti-oxidant levels in GSH, SOD and CAT and increased the rectal temperature and lipid peroxidase level compare to control rats pretreated with Aspirin 200 mg/kg rats and fenchone (200 and 400 mg/kg) rats significantly attenuated the CUMS induced behavioral changes, oxidative damage and neuronal damage. Conclusion: Fenchone showed neuroprotective activity due to the presence of Antioxidants.

Keywords: Neuroinflammation, fenchone, Hippocampus, CUMS

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