DOUBLE BLIND RANDOMIZED CONTROLLED STUDY ON THE EFFICACY OF ASPARAGUS RACEMOSUS MOTHER TINCTURE IN HYPERLIPIDEMIA

  • Geeta B Adi Assistant Professor, Department of Repertory, Bharatesh Homoeopathic Medical College, Belagavi.
  • Basavaraj S Ad Associate Professor, Department of Pharmacy, Bharatesh Homoeopathic Medical College, Belagavi.
  • Siva Rami Reddy E Faculty of Homoeopathy, Tantia University, Sri Ganganagar, Rajasthan, India.

Abstract

Aim: Asparagus racemosus has anti toxidant, anti inflammatory and anti diabetic activities. In the present double blind randomized controlled study is that efficacy of asparagus racemosus mother tincture in hyperlipidemia. Hyperlipidemia patients meeting the inclusion criteria were randomly assigned in to the treatment and placebo. Methods: 50 patients in treatment group took asparagus racemosus mother tincture; whereas the patients in placebo group took placebo mother tincture for 12 weeks. The lipid profiles of the patients were evaluated at baseline, and after 6 and 12 weeks of the double blind randomized controlled study. Results: The final results showed that asparagus racemosus mother tincture significantly p value 0.05 improved LDL, HDL, cholesterol, compared to the placebo group. The asparagus racemosus showed an inhibitory effect on of hepatic enzymes and possible liver toxicity. No serious side effect was reported for asparagus racemosus mother tincture administration. Therefore, asparagus racemosus mother tincture could be considered as a supplement for treatment of dyslipidemia.

Keywords: Double blind randomized controlled study,, hyperlipidemia, asparagus racemosus

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References

1. Kirtikar, Basu. Indian medicinal plants. Dehradun, India: Bishen Singh Mahendra Pal Singh 1985.
2. Goyal R, Singh Jand Lal H: Asparagus racemosus--an update. Indian J Med Sci 2003; 57:408-414.
3. Gomase V and Sherkhane A: Isolation, structure elucidation and biotransformation studies on secondary metabolites from Asparagus racemosus. Int J Microbiol Res 2010; 2:07-09.
4. Sahu M, Gupta S and Srivastava P: Effect of Renalka syrup in Urinary Tract Infection. Indian Pract 2002; 55:101-106.
5. Sharma M, Sharma A and Kumar A: Vital medicine Asparagus racemosus wild. Curr Trends Biotechnol Pharm 2012; 6:210-221.
6. Roy RN, Bhagwager S, Chavan SR, Dutta NK. Preliminary pharmacological studies on extracts of root of Asparagus racemosus (Satavari), Willd, Lilliaceae. J Res Indian Med. 1971; 6:132–138.
7. Sekine TN. Fukasawa Structure of asparagamine A, a novel polycyclic alkaloid from Asparagus racemosus. Chem Pharm Bull Tokyo. 1994;42(6):1360–1362.
8. Potduang B, Meeploy M, Giwanon R, Benmart Y, Kaewduang M and Supatanakul W: Biological activities of Asparagus racemosus. Afr J Tradit Complement Alter Med 2008; 5:230-237.
9. Visavadiya NP and Narasimhacharya A: Asparagus root regulates cholesterol metabolism and improves antioxidant status in hypercholesteremic rats. Evid Based Complement Alter Medicine 2009; 6:219-226.
10. Narendranath KA, Mahalingam S, Anuradha V, Rao IS. Effect of herbal galactogogue (Lactare) a pharmacological and clinical observation. Med Surg. 1986; 26:19–22.
11. Kundu M, Mazumder R, Kushwaha M, Chakraborthy G and Kundu M: Standardization profiles of roots of Asparagus racemosus wild. Pharmacologyonline 2011; 3:587-592.
12. Bose S, Show S, Hazra M and Sarkar T: Comparative study of Antioxidant Activity of Herbal Drugs and their Formulations using Asparagus racemosus and Centella asiatica. Am J PharmTech Res 2012; 2:391-398.
13. Sekine T, Ikegami F, Fukasawa N, Kashiwagi Y, Aizawa T, Fujii Y, Ruangrungsi N and Murakoshi I: Structure and relative stereochemistry of a new polycyclic alkaloid, asparagamine A, showing anti-oxytocin activity, isolated from Asparagus racemosus. J Chem Soc Perkin Transact 1 1995:391-393.
14. Bhatnagar M, Sisodia SS andBhatnagar R: Antiulcer and antioxidant activity of Asparagus racemosus Wild and Withania somnifera Dunal in rats. Ann N Y Acad Sci 2005; 1056:261-278.
15. Wiboonpun N, Phuwapraisirisan P, Tip-pyang S. Identification of antioxidant compound from Asparagus racemosus. Phytother Res. 2004;8(9):771–773.
16. Jalalpure S, Bagewadi V and Shaikh I: Antiepileptic effect of Asparagus racemosus root extracts. J Trop Med Plants 2009; 10:157-161.
17. Tiwari A, Agarwal A, Shukla S and Dubey G: Favourable effect of Abana on lipoprotein profiles of patients with hypertension and angina pectoris. Altern Med 1990; 3:139-42.
18. Garde GK, Vagbhat S. Marathia translation of vagbhat's astangahridya. Uttarstana: Aryabhushana Mudranalaya; 1970. pp. 40–48.
19. Zhu X, Zhang W, Zhao J, Wang J, Qu W. Hypolipidaemic and hepatoprotective effects of ethanolic and aqueous extracts from Asparagus officinalis L. by-products in mice fed a high-fat diet. J Sci Food Agric. 2010; 90(7):1129–1135.
20. Takeungwongtrakul S, Benjakul S, H-Kittikun A. Lipids from cephalothorax and hepatopancreas of Pacific white shrimp (Litopenaeus vannamei): Compositions and deterioration as affected by iced storage. Food Chem. 2012; 134(4):2066–2074.
Published
31/12/2018
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[1]
G. B. A. Geeta B Adi, B. S. A. Basavaraj S Ad, and S. R. R. E. Siva Rami Reddy E, “DOUBLE BLIND RANDOMIZED CONTROLLED STUDY ON THE EFFICACY OF ASPARAGUS RACEMOSUS MOTHER TINCTURE IN HYPERLIPIDEMIA ”, Int J Indig Herb Drug, pp. 1-7, Dec. 2018.
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Research Articles